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J Sex Med:睾酮治疗和心血管风险

2021-01-03 AlexYang MedSci原创

外源性睾酮疗法(TTh)治疗 "成年性腺功能减退症"(AOH)能提高血清睾酮(T)水平,但可能会影响AOH患者的心血管(CV)风险因素,且低内源性T水平与CV风险和死亡率的增加有关。

外源性睾酮疗法(TTh)治疗 "成年性腺功能减退症"(AOH)能提高血清睾酮(T)水平,但可能会影响AOH患者的血管(CV)风险因素,且低内源性T水平与CV风险和死亡率的增加有关。

最近,有研究人员批判性评估了报道与TTh相关的CV风险增加的研究,并概述了通过外源性TTh恢复T水平的风险和益处。研究人员对关注于TTh和CV风险增加的出版物进行了回顾,并对每个研究的方法和结论进行了批判性评估。此外,研究人员还回顾了近期AOH或TTh与CV风险变化相关的临床和流行病学研究等。研究结果表明,文献中的大量研究显示了使用TTh的积极益处;然而,自2013年以来,一些出版物表明TTh与CV风险增加有关。很多这样的研究使用诊断代码、程序代码和处方信息回顾性地分析了保险索赔数据库。此后发表的许多综述都指出了这些研究的方法学缺陷和仍有争议的结论。

最后,研究人员指出,治疗前低T水平患者的适当选择,并在治疗过程中监测T水平,从而达到和维持生理水平为目标,均有助于在AOH男性中安全有效地使用TTh

原始出处:

Mohit Khera, Martin Miner, Jonathan Jaffe et al. Testosterone Therapy and Cardiovascular Risk: A Critical Analysis of Studies Reporting Increased Risk. J Sex Med. Jan 2021

 

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    2021-01-09 ms3000000449926787

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