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Circulation:侵入性治疗非ST抬高心梗高危患者血管造影的时机和结局

2017-09-12 xiangting MedSci原创

对高危NSTEMI患者,在入院后的最初12小时内进行CAG与180天的缺血性结局风险降低相关。

对于全球急性冠脉事件登记(GRACE)评分>140的非ST段抬高型心梗(NSTEMI)患者,欧洲和美国的指南推荐在24小时内进行冠脉造影(CAG)。这篇文章试图研究GRACE评分>140的NSTEMI"超早期"(即≤12h),早期(12-24h)和延迟(>24h)CAG与缺血性结局的相关性。

奥米沙班治疗急性冠脉综合征试验(TAO),将NSTEMI患者随机分为CAG组,72h内给予肝素加依替巴肽,和奥米沙班组。在这项析因分析中,GRACE评分>140的患者根据入院到CAG的时间分为3组(<12h,≥12h-<24h,≥24h)。原发性缺血性结局是随机化180天内的全因死亡和心肌梗死(MI)的复合。

4071例患者进行CAG(<12h n=1648(40.5%),12-24h n=1420(34.9%),≥24h n=1003(24.6%))。以CAG≥24h为参考,12-24小时CAG与180天的原发性缺血性结局的风险较低没有相关性(优势比(OR)为0.96,95%置信区间(CI)为0.75-1.23),而CAG <12h与死亡和心肌梗死风险较低相关(OR 0.71,95%CI 0.55-0.91)。与12-24小时进行CAG相比,<12h进行CAG与死亡和MI风险降低相关(OR 0.76,95%IC 0.61-0.94; p = 0.01)。出血并发症没有差异。

对高危NSTEMI患者,在入院后的最初12小时内进行CAG与180天的缺血性结局风险降低相关。

原始出处:

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    2017-09-14 heli0118
  4. [GetPortalCommentsPageByObjectIdResponse(id=1955757, encodeId=d9691955e5756, content=<a href='/topic/show?id=5b0b1022667b' target=_blank style='color:#2F92EE;'>#高危患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102266, encryptionId=5b0b1022667b, topicName=高危患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Sun Aug 26 03:47:00 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028760, encodeId=ea9d2028e60f6, content=<a href='/topic/show?id=b1e1269e5c6' target=_blank style='color:#2F92EE;'>#侵入性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26975, encryptionId=b1e1269e5c6, topicName=侵入性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4736501, createdName=xiaoyang_ambs, createdTime=Sun Oct 08 16:47:00 CST 2017, time=2017-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494041, encodeId=007114940412b, content=<a href='/topic/show?id=3e34949e333' target=_blank style='color:#2F92EE;'>#造影#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94973, encryptionId=3e34949e333, topicName=造影)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Sep 14 01:47:00 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243418, encodeId=713224341875, content=好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Wed Sep 13 05:42:24 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243202, encodeId=29cd24320293, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Sep 12 12:35:57 CST 2017, time=2017-09-12, status=1, ipAttribution=)]
    2017-09-13 smartxiuxiu

    好!

    0

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    2017-09-12 清风拂面

    谢谢分享.学习了

    0

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