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J Endod:中性粒细胞外诱捕网对牙髓产生潜在的毒性及促炎症作用

2019-04-29 lishiting MedSci原创

中性粒细胞外诱捕网(NETs)是一种重要的先天免疫机制,旨在限制组织内细菌的扩散以及定位抗菌杀灭机制。学者们对NETs在感染和炎症疾病范围中的作用产生极大的兴趣;然而,它们在感染牙髓中的作用还未可知。这篇研究的目的是为了检测它们与感染牙髓的关系以及它们的成分如何影响人牙髓细胞(HDPC)反应。

中性粒细胞外诱捕网(NETs)是一种重要的先天免疫机制,旨在限制组织内细菌的扩散以及定位抗菌杀灭机制。学者们对NETs在感染和炎症疾病范围中的作用产生极大的兴趣;然而,它们在感染牙髓中的作用还未可知。这篇研究的目的是为了检测它们与感染牙髓的关系以及它们的成分如何影响人牙髓细胞(HDPC)反应。研究对感染牙髓染色来检测胞外DNA和弹性蛋白酶的存在,以确定NETs的存在。也检测感染牙髓的已知细菌以确定它们刺激NETs的能力。共培养研究和NET成分分析来确定胞外NET释放对HDPC活性及炎症反应的影响。检测NET刺激的HDPC分泌蛋白组以分析它们向淋巴细胞和巨噬细胞趋化性的能力。结果显示,NETs存在于感染牙髓组织中,整个NETs以及它们的组蛋白成分,特别是H2A,减少HDPC活性并刺激趋化因子的释放,进而导致淋巴细胞群落的聚集。结论:NETs很可能在HDPCs损伤和慢性感染的牙髓发病机制中起到重要作用,它可能会促进疾病进展。巨噬细胞趋化于NET诱导的HDPCs凋亡,促进细胞碎屑移除。NETs及其组蛋白可能为牙髓疾病提供了全新的预测蛋白或/和治疗靶点。原始出处:Holder MJ, Wrig

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    2020-02-07 jxrzshh
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    2019-04-29 329523732

    不错

    0

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