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CMAJ:血液中一种生物标志物,可以更准确地预测死亡

2016-12-04 佚名 生物探索

想知道未来5年内的死亡风险吗?如今,科学家找到了一种方法来预测死亡风险,他们在血液中发现了一种生物标志物可以用来检测癌症、慢性心脏病和其他严重的疾病。专家表示,与以前的方法相比,新方法可以更加准确的评估死亡风险。相关结果于本周发表在Canadian Medical Association Journal杂志上。研究人员发现新的生物标志物能更准确的预测死亡此前,一项涉及106个生物标志物的研究表明,

想知道未来5年内的死亡风险吗?如今,科学家找到了一种方法来预测死亡风险,他们在血液中发现了一种生物标志物可以用来检测癌症、慢性心脏病和其他严重的疾病。专家表示,与以前的方法相比,新方法可以更加准确的评估死亡风险。相关结果于本周发表在Canadian Medical Association Journal杂志上。

此前,一项涉及106个生物标志物的研究表明,炎症标志物α1-酸性糖蛋白(AGP)与5年内死亡率的相关性最强。然而,这些新研究却发现,白细胞介素-6(IL-6)是更为准确的死亡预测因子。

在该研究中,伦敦大学的Archana Singh-Manoux教授带领团队探讨了作为死亡风险的生物标志物,AGP是否比其他的常用炎症生物标志如IL-6、C反应蛋白(CRP)更准确。

该研究涉及了6545名45岁至69岁的男性,研究人员对这些志愿者进行了随访,在随访期间观察了他们的存活情况,并分析其炎症标志物。

平均随访时间为16.7年。在这期间,共有736个死亡案例,其中181名死于心血管疾病,347名死于癌症。研究人员将所有的可变因素(年龄、性别、社会经济地位、身体质量指数、健康行为以及慢性病)都考虑在内,结果发现,在第一个5年随访期中,AGP并不能准确预测死亡率,而IL-6和CRP在该时期内与死亡率的相关性更强。

当同时考虑所有的可变因素和生物标志物时,研究人员发现在整个随访期间,AGP并不能预测全因死亡率,只有IL-6能预测全因死亡率以及与肿瘤相关的死亡率,CRP能预测心血管死亡率。

最后研究人员得出以下结论:与IL-6和CRP相比,AGP并不是预测短期或长期死亡风险的最好生物标志物。

生物标志物需要验证

Manoux教授表示,这项技术非常的令人激动。他说,“生物标志物的研究进展很快,重要的是要对它们进行验证,以推动未来研究的发展。”

哈佛医学院的Paul Ridker在相关评论中表示,“生物标志物的发现,对新的治疗靶点至关重要。关于AGP、CRP和IL-6,我们仍然不知道的减少炎症是否能降低心血管事件的发生率。”

去年,英国开发了一个名为Ubble的长寿探测器,该工具是基于英国生物样本库(UKBiobank)注册者对655道与生活方式相关的问题的答案,该样本库包含了50万名志愿者的DNA和医疗历史数据库,目的是为了查明基因与生活方式之间的联系。该研究是继Ubble工具之后的又一个预测死亡风险的成果。


原始出处:

Singh-Manoux A, Shipley MJ, Bell JA, Canonico M, Elbaz A, Kivimäki M.  between inflammatory biomarkers and all-cause, cardiovascular and cancer-related mortality. CMAJ. 2016 Nov 28. pii: cmaj.160313

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    2016-12-20 SAd

    预测死亡?呵呵

    0

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    2016-12-06 yfjms

    如何设计随机分配?如何排除其他因素?

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1840940, encodeId=ee911840940cb, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sun Nov 12 20:39:00 CST 2017, time=2017-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164271, encodeId=80a61642e1bf, content=预测死亡?呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e9c1996425, createdName=SAd, createdTime=Tue Dec 20 08:55:28 CST 2016, time=2016-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160570, encodeId=46021605e0a8, content=如何设计随机分配?如何排除其他因素?, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Tue Dec 06 06:54:16 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560580, encodeId=ae3a15605802b, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Dec 06 01:39:00 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566589, encodeId=24ef1566589bf, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Dec 06 01:39:00 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160483, encodeId=0215160483a8, content=真的啊?!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Dec 05 19:58:36 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160208, encodeId=104d16020880, content=要能预测死亡,那离解决死亡的问题就不远了, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/6D9C89AB36A71EA450A5729452654834/100, createdBy=b07f1943308, createdName=博雷, createdTime=Sun Dec 04 14:41:29 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160187, encodeId=863116018e23, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Dec 04 12:11:37 CST 2016, time=2016-12-04, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1840940, encodeId=ee911840940cb, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sun Nov 12 20:39:00 CST 2017, time=2017-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164271, encodeId=80a61642e1bf, content=预测死亡?呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e9c1996425, createdName=SAd, createdTime=Tue Dec 20 08:55:28 CST 2016, time=2016-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160570, encodeId=46021605e0a8, content=如何设计随机分配?如何排除其他因素?, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Tue Dec 06 06:54:16 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560580, encodeId=ae3a15605802b, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Dec 06 01:39:00 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566589, encodeId=24ef1566589bf, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Dec 06 01:39:00 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160483, encodeId=0215160483a8, content=真的啊?!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Dec 05 19:58:36 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160208, encodeId=104d16020880, content=要能预测死亡,那离解决死亡的问题就不远了, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/6D9C89AB36A71EA450A5729452654834/100, createdBy=b07f1943308, createdName=博雷, createdTime=Sun Dec 04 14:41:29 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160187, encodeId=863116018e23, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Dec 04 12:11:37 CST 2016, time=2016-12-04, status=1, ipAttribution=)]
    2016-12-05 thlabcde

    真的啊?!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1840940, encodeId=ee911840940cb, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sun Nov 12 20:39:00 CST 2017, time=2017-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164271, encodeId=80a61642e1bf, content=预测死亡?呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e9c1996425, createdName=SAd, createdTime=Tue Dec 20 08:55:28 CST 2016, time=2016-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160570, encodeId=46021605e0a8, content=如何设计随机分配?如何排除其他因素?, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Tue Dec 06 06:54:16 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560580, encodeId=ae3a15605802b, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Dec 06 01:39:00 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566589, encodeId=24ef1566589bf, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Dec 06 01:39:00 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160483, encodeId=0215160483a8, content=真的啊?!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Dec 05 19:58:36 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160208, encodeId=104d16020880, content=要能预测死亡,那离解决死亡的问题就不远了, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/6D9C89AB36A71EA450A5729452654834/100, createdBy=b07f1943308, createdName=博雷, createdTime=Sun Dec 04 14:41:29 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160187, encodeId=863116018e23, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Dec 04 12:11:37 CST 2016, time=2016-12-04, status=1, ipAttribution=)]
    2016-12-04 博雷

    要能预测死亡,那离解决死亡的问题就不远了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1840940, encodeId=ee911840940cb, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sun Nov 12 20:39:00 CST 2017, time=2017-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=164271, encodeId=80a61642e1bf, content=预测死亡?呵呵, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e9c1996425, createdName=SAd, createdTime=Tue Dec 20 08:55:28 CST 2016, time=2016-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160570, encodeId=46021605e0a8, content=如何设计随机分配?如何排除其他因素?, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Tue Dec 06 06:54:16 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560580, encodeId=ae3a15605802b, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Dec 06 01:39:00 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566589, encodeId=24ef1566589bf, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Dec 06 01:39:00 CST 2016, time=2016-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160483, encodeId=0215160483a8, content=真的啊?!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Mon Dec 05 19:58:36 CST 2016, time=2016-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160208, encodeId=104d16020880, content=要能预测死亡,那离解决死亡的问题就不远了, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/6D9C89AB36A71EA450A5729452654834/100, createdBy=b07f1943308, createdName=博雷, createdTime=Sun Dec 04 14:41:29 CST 2016, time=2016-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=160187, encodeId=863116018e23, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sun Dec 04 12:11:37 CST 2016, time=2016-12-04, status=1, ipAttribution=)]
    2016-12-04 dhzzm

    学习了,很好

    0

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J Proteome Res:在山里待上两周,你的血液就会发生改变

导语:经过一个晚上,人类的身体就会开始适应高海拔环境,而且这种适应能力所带来的生物学改变能够持续数月——也就是说,即使这个人后来返回了低海拔的环境,这种改变也会维持一段时间。最近,为了观察低氧环境中的多重变化如何影响红细胞的保有氧气的能力,科学家们有史以来第一次比较了登山者的血液——他们发现在几小时内登山者的血液就会发生改变。该研究反驳了一个持续了半个世纪的假说,该假说表明,与平均海拔地区的人相比

Nat Med:血液中的循环肿瘤细胞可以预测肺癌治疗效果

肺癌是全世界发病率和死亡率最高的癌症之一。肺癌主要分为小细胞肺癌和非小细胞肺癌两大类。不同类型的肺癌,治疗策略和预后情况也不尽相同。Nature Medicine发表的一项新研究表明,血检可以预测小细胞肺癌(SCLC)患者对治疗的应答情况。在癌症的发展过程中,肿瘤细胞会离开实体瘤进入血液循环,成为循环肿瘤细胞(CTC)。曼彻斯特大学的研究人员从31名小细胞肺癌患者的血液中分离循环肿瘤细胞进行研究。

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