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Chest:睡眠呼吸暂停增加因房颤住院的风险

2018-09-22 xing.T MedSci原创

由此可见,在疑似OSA的大型无心律失常临床队列中,夜间低氧血症与房颤住院风险增加77%独立相关。这些发现进一步支持了OSA、夜间低氧血症和新发AF的关系,其可用于增强OSA和严重夜间低氧血症患者的房颤预防。

近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员通过一个大型无心律失常的队列中评估了新诊断的阻塞性睡眠呼吸暂停(OSA)与随后10年间房颤住院之间的关系。

研究人员纳入了1994年至2010年期间转诊至大型教学医院的疑似OSA患者,这些患者在首次诊断性睡眠检查时无心律失常。临床数据与省级卫生行政数据相关联,以确定患者结局。研究人员使用Cox回归来研究通过呼吸暂停-低通气指数(AHI)衡量的OSA严重程度与夜间低氧血症程度和因房颤住院之间的关系。

该研究总共纳入了8256名受试者:中位年龄为47岁,62%为男性,28%的患者AHI>30%,6%的患者>30%的睡眠时间血氧饱和度<90%。中位随访10年(IQR为7-13年),173名参与者(2.1%)因房颤住院。控制年龄、性别、饮酒、吸烟状况、既往心力衰竭、COPD和肺栓塞后,夜间低氧血症,而非AHI,是房颤的重要预测指标:HR为2.47(95%CI为1.64-3.71)。在进一步控制BMI和高血压后,这种关联减弱,但仍然显著:HR为1.77(1.15-2.74)。

由此可见,在疑似OSA的大型无心律失常临床队列中,夜间低氧血症与房颤住院风险增加77%独立相关。这些发现进一步支持了OSA、夜间低氧血症和新发AF的关系,其可用于增强OSA和严重夜间低氧血症患者的房颤预防

原始出处:

Tetyana Kendzerska,et al. Sleep Apnea Increases the Risk of New Hospitalized Atrial Fibrillation: A Historical Cohort Study.chest.2018. https://doi.org/10.1016/j.chest.2018.08.1075

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    2019-04-26 Smile2680
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