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阜外医院研究称,原醛占高血压住院患者5.2%,合并低钾血症者靶器官损害更重

2018-09-26 xujing 中国循环杂志

阜外医院蔡军、刘小宁等发表阜外医院单中心数据显示,原发性醛固酮增多症患者较原发性高血压患者靶器官损害重,存在低钾血症的原发性醛固酮增多症患者更甚。


阜外医院蔡军、刘小宁等发表阜外医院单中心数据显示,原发性醛固酮增多症患者较原发性高血压患者靶器官损害重,存在低钾血症的原发性醛固酮增多症患者更甚。
 
原发性醛固酮增多症占所有高血压住院患者的5.2%,是继发性高血压的第三大病因(占16.8%),是内分泌性高血压的第一大病因(占66.6%)。
 
阜外医院目前主要采用静脉生理盐水试验和卡托普利试验。分型诊断则根据肾上腺影像学检查和分侧肾上腺静脉采血。
 
高血压伴低钾血症是原发性醛固酮增多症的典型临床表现。本研究中低钾血症的PA 患者占57.9%。
 
与血钾正常的原发性醛固酮增多症患者比较,低钾血症原发性醛固酮增多症患者虽然年龄小,但血醛固酮水平高,尿微量白蛋白/ 肌酐比值高,左心室质量指数(LVMI)高。这提示存在低钾血症的原发性醛固酮增多症患者靶器官损害更早、更重。
 
本研究中有56 例(22.7%)原发性醛固酮增多症患者合并中、重度睡眠呼吸暂停综合征。
 
本研究中,与原发性高血压患者相比,原发性醛固酮增多症患者虽然LDL-C、总胆固醇、糖化血红蛋白水平均较低,但合并冠心病、外周动脉疾病的比例反而较高。
 
研究纳入阜外医院高血压病房收治的4 782例高血压患者资料,将其中的原发性醛固酮增多症患者与原发性高血压患者根据年龄、性别1:2 匹配后比较其临床特征,并比较血钾正常和低钾血症(<3.5 mmol/L)原发性醛固酮增多症患者的临床特征。

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    2019-05-28 habb
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