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Diabetes Metab Res Rev:同济医学院研究称,“健康的胖”只是传说

2019-08-07 卢芳 中国循环杂志

有一种胖,血压、血脂、血糖都正常,也不存在什么脂肪肝,这种胖真的很健康?

有一种胖,血压、血脂、血糖都正常,也不存在什么脂肪肝,这种胖真的很健康?

近日一项同济医学院公共卫生学院何美安等对近1.8万人进行的研究,揭开了这种胖的“伪装”:这种肥胖者比正常体重者会有近两倍得糖尿病的风险。

“代谢正常肥胖增加得糖尿病风险,与一个人有没有非酒精性脂肪肝没什么关系。这项研究进一步说明,不存在什么代谢正常性肥胖,体重超标的人还是应该注意一下减重。”何美安指出。

研究显示,那些代谢正常的超重者,得糖尿病的风险是体重保持正常者的1.5倍;而代谢正常的肥胖者则风险更高,增加1.74倍的风险。

当然如果一个人代谢紊乱的话,得糖尿病的风险会更高,比如代谢异常的正常体重者、超重者、肥胖者就会分别增加1.39倍、1.93倍和2.15倍的糖尿病罹患风险。

研究还发现,代谢正常的胖人,若同时有脂肪肝,就会比正常体重者增加2.24倍的糖尿病罹患风险;若无脂肪肝,也有2.71倍的糖尿病风险。

这项研究也是东风-同济研究的最新结果,其中共分析了17801位受试者,平均年龄63.2岁,55.1%为女性。其中肥胖定义为体重指数(BMI)≥28 kg/m2,超重的BMI在24~27.9 kg/m2,正常体重在18.5~23.9 kg/m2。平均随访4.6年期间,共有1453人罹患糖尿病。

对于代谢正常的所谓“良性”肥胖的研究有很多了,之前上海瑞金医院宁光等在21余万国人中进行的研究也证实“良性”肥胖不存在。

他们的研究显示,只要胖,不管是体态均匀的肥胖还是腹部肥胖,也不论胰岛素抵抗在或不在,10年内得心血管病的可能性都会大大增加。

比如虽然胰岛素敏感性均正常,但全身胖者比不胖的人,10年内患心血管病和冠心病的可能性也要增加2倍左右;仅肚子胖的人,要比腰不肥的人得心血管病和冠心病的可能性都要增加近1.5倍。

总之,胖是一种病,得减!

原始出处:Wei Y1, Wang J1, Han X1, et al. Metabolically healthy obesity increased diabetes incidence in a middle-aged and elderly Chinese population. Diabetes Metab Res Rev. 2019 Jul 10

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