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Cell：科学家发现天然免疫抗肿瘤新分子

2015-02-16 佚名 生物谷

抗肿瘤新分子
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近日，来自意大利的研究人员在著名国际期刊cell发表了一项最新研究进展，他们发现固有免疫重要成成分PTX3能够通过调节补体依赖性炎症过程发挥抗肿瘤功能。这项成果进一步阐述了肿瘤与炎症之间的关系，对于研究如何通过调节炎症过程影响肿瘤发生具有重要意义。 研究人员指出，PTX3是固有免疫体液组成中的一个重要组成成分，在抵抗特异性微生物以及调控炎症方面发挥重要作用。PTX3能够通过与C1q和H因子相

近日，来自意大利的研究人员在著名国际期刊cell发表了一项最新研究进展，他们发现固有免疫重要成成分PTX3能够通过调节补体依赖性炎症过程发挥抗肿瘤功能。这项成果进一步阐述了肿瘤与炎症之间的关系，对于研究如何通过调节炎症过程影响肿瘤发生具有重要意义。

研究人员指出，PTX3是固有免疫体液组成中的一个重要组成成分，在抵抗特异性微生物以及调控炎症方面发挥重要作用。PTX3能够通过与C1q和H因子相互作用，激活和调节补体级联反应。PTX3缺陷与间叶细胞和上皮细胞癌症发生的易感性增加具有明显相关性。
 
研究人员发现，Ptx3-/-小鼠会出现巨噬细胞浸润，细胞因子合成，血管生成以及Trp53突变增加等表型，这些变化都与癌症发生的易感性增加相关。相关实验证据，基因靶向小鼠和药理学阻断实验证明PTX3缺陷会导致补体激活，CCL2合成，促肿瘤巨噬细胞招募增加。同时，研究人员还发现在特定人类肿瘤中（比如平滑肌肉瘤和结肠癌），PTX3表达会受到表观遗传调控，在PTX3的启动子区域以及增强子区域发生甲基化抑制其表达。因此，PTX3作为固有免疫体液组成中的一个效应分子，通过调控补体和巨噬细胞依赖性的促肿瘤炎症过程，发挥了重要的抑癌作用。
 
综上所述，这项研究阐述了PTX3通过影响补体介导的炎症反应发挥抗肿瘤功能的新机制，对于研究如何通过调节炎症过程影响肿瘤发生具有重要意义。

原始出处

Bonavita E1, Gentile S1, Rubino M1, Maina V1, Papait R2, Kunderfranco P1, Greco C1, Feruglio F1, Molgora M1, Laface I1, Tartari S1, Doni A1, Pasqualini F1, Barbati E1, Basso G1, Galdiero MR1, Nebuloni M3, Roncalli M1, Colombo P1, Laghi L1, Lambris JD4, Jaillon S1, Garlanda C5, Mantovani A6.PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer.Cell. 2015 Feb 12

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    2015-02-23 旅苦化文_208

    #科学家发现#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1802247, encodeId=1dcb180224e0f, content=<a href='/topic/show?id=acfae485578' target=_blank style='color:#2F92EE;'>#科学家发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74855, encryptionId=acfae485578, topicName=科学家发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Mon Feb 23 21:25:00 CST 2015, time=2015-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959282, encodeId=d3c6195928251, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Mar 05 04:25:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869031, encodeId=f67b186903174, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jan 23 07:25:00 CST 2016, time=2016-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23683, encodeId=39e8236830e, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Sat May 16 19:27:00 CST 2015, time=2015-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923235, encodeId=0175192323577, content=<a href='/topic/show?id=b30358095ea' target=_blank style='color:#2F92EE;'>#新分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58095, encryptionId=b30358095ea, topicName=新分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Tue Jun 16 07:25:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16719, encodeId=11d416e19b1, content=不错的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sun Feb 22 09:26:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481265, encodeId=298a148126555, content=<a href='/topic/show?id=c5534414ee6' target=_blank style='color:#2F92EE;'>#天然免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44147, encryptionId=c5534414ee6, topicName=天然免疫)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Feb 18 00:25:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15623, encodeId=1743156233d, content=以阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 13:11:00 CST 2015, time=2015-02-16, status=1, ipAttribution=)]
    2015-03-05 维他命

    #CEL#

    0

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    2016-01-23 zhaozhouchifen

    #Cell#

    0

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    2015-05-16 ljjj1053

    很不错学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1802247, encodeId=1dcb180224e0f, content=<a href='/topic/show?id=acfae485578' target=_blank style='color:#2F92EE;'>#科学家发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74855, encryptionId=acfae485578, topicName=科学家发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Mon Feb 23 21:25:00 CST 2015, time=2015-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959282, encodeId=d3c6195928251, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Mar 05 04:25:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869031, encodeId=f67b186903174, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jan 23 07:25:00 CST 2016, time=2016-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23683, encodeId=39e8236830e, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Sat May 16 19:27:00 CST 2015, time=2015-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923235, encodeId=0175192323577, content=<a href='/topic/show?id=b30358095ea' target=_blank style='color:#2F92EE;'>#新分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58095, encryptionId=b30358095ea, topicName=新分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Tue Jun 16 07:25:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16719, encodeId=11d416e19b1, content=不错的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sun Feb 22 09:26:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481265, encodeId=298a148126555, content=<a href='/topic/show?id=c5534414ee6' target=_blank style='color:#2F92EE;'>#天然免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44147, encryptionId=c5534414ee6, topicName=天然免疫)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Feb 18 00:25:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15623, encodeId=1743156233d, content=以阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 13:11:00 CST 2015, time=2015-02-16, status=1, ipAttribution=)]
    2015-06-16 12498761m56暂无昵称

    #新分子#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1802247, encodeId=1dcb180224e0f, content=<a href='/topic/show?id=acfae485578' target=_blank style='color:#2F92EE;'>#科学家发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74855, encryptionId=acfae485578, topicName=科学家发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Mon Feb 23 21:25:00 CST 2015, time=2015-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959282, encodeId=d3c6195928251, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Mar 05 04:25:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869031, encodeId=f67b186903174, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jan 23 07:25:00 CST 2016, time=2016-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23683, encodeId=39e8236830e, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Sat May 16 19:27:00 CST 2015, time=2015-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923235, encodeId=0175192323577, content=<a href='/topic/show?id=b30358095ea' target=_blank style='color:#2F92EE;'>#新分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58095, encryptionId=b30358095ea, topicName=新分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Tue Jun 16 07:25:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16719, encodeId=11d416e19b1, content=不错的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sun Feb 22 09:26:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481265, encodeId=298a148126555, content=<a href='/topic/show?id=c5534414ee6' target=_blank style='color:#2F92EE;'>#天然免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44147, encryptionId=c5534414ee6, topicName=天然免疫)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Feb 18 00:25:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15623, encodeId=1743156233d, content=以阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 13:11:00 CST 2015, time=2015-02-16, status=1, ipAttribution=)]
    2015-02-22 orthoW

    不错的文章，学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1802247, encodeId=1dcb180224e0f, content=<a href='/topic/show?id=acfae485578' target=_blank style='color:#2F92EE;'>#科学家发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74855, encryptionId=acfae485578, topicName=科学家发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Mon Feb 23 21:25:00 CST 2015, time=2015-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959282, encodeId=d3c6195928251, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Mar 05 04:25:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869031, encodeId=f67b186903174, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jan 23 07:25:00 CST 2016, time=2016-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23683, encodeId=39e8236830e, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Sat May 16 19:27:00 CST 2015, time=2015-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923235, encodeId=0175192323577, content=<a href='/topic/show?id=b30358095ea' target=_blank style='color:#2F92EE;'>#新分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58095, encryptionId=b30358095ea, topicName=新分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Tue Jun 16 07:25:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16719, encodeId=11d416e19b1, content=不错的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sun Feb 22 09:26:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481265, encodeId=298a148126555, content=<a href='/topic/show?id=c5534414ee6' target=_blank style='color:#2F92EE;'>#天然免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44147, encryptionId=c5534414ee6, topicName=天然免疫)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Feb 18 00:25:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15623, encodeId=1743156233d, content=以阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 13:11:00 CST 2015, time=2015-02-16, status=1, ipAttribution=)]
    2015-02-18 仁心济世

    #天然免疫#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1802247, encodeId=1dcb180224e0f, content=<a href='/topic/show?id=acfae485578' target=_blank style='color:#2F92EE;'>#科学家发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74855, encryptionId=acfae485578, topicName=科学家发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Mon Feb 23 21:25:00 CST 2015, time=2015-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959282, encodeId=d3c6195928251, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Mar 05 04:25:00 CST 2015, time=2015-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869031, encodeId=f67b186903174, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sat Jan 23 07:25:00 CST 2016, time=2016-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23683, encodeId=39e8236830e, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Sat May 16 19:27:00 CST 2015, time=2015-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923235, encodeId=0175192323577, content=<a href='/topic/show?id=b30358095ea' target=_blank style='color:#2F92EE;'>#新分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58095, encryptionId=b30358095ea, topicName=新分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Tue Jun 16 07:25:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16719, encodeId=11d416e19b1, content=不错的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sun Feb 22 09:26:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481265, encodeId=298a148126555, content=<a href='/topic/show?id=c5534414ee6' target=_blank style='color:#2F92EE;'>#天然免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44147, encryptionId=c5534414ee6, topicName=天然免疫)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Feb 18 00:25:00 CST 2015, time=2015-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15623, encodeId=1743156233d, content=以阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 13:11:00 CST 2015, time=2015-02-16, status=1, ipAttribution=)]
    2015-02-16 windmilL1989

    以阅

    0

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