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J Gastroen Hepatol:麸质饮食对功能性消化不良的影响

2017-12-30 zhangfan MedSci原创

研究发现,功能性消化不良患者麸质饮食频率及数量增加,可导致早期饱腹等不适症状,组织上引发肠上皮屏障功能障碍和粘膜免疫激活造成幽门螺杆菌易感

饮食因素和免疫功能障碍可能导致功能性消化不良(FD)患者出现不适症状。近日研究人员评估了麸质饮食对FD患者疾病症状以及十二指肠组织学的影响。

研究招募了101名新发FD患者以及31名无症状对照者。根据自我报告的问卷调查评估患者FD特异性症状以及麸质饮食,采用免疫组织化学方法检测十二指肠紧密连接蛋白(claudin-1)的表达及上皮内淋巴细胞(IEL)在十二指肠球部(D1)和第二部(D2)的浸润情况。

研究发现,FD患者高麸质饮食的频率(P = 0.047)和数量(P = 0.01)高于对照组。101名FD患者中早饱感(P = 0.03)与麸质的摄入量以及频率增加相关。患者组织评估中,D1(0.003 ± 0.001 vs 0.012 ± 0.002,P = 0.003)以及D2(0.002 ± 0.0004 vs 0.012 ± 0.001,P < 0.001),十二指肠紧密连接蛋白表达较少,而D1 (15.5 ± 7.8 vs 3.1 ± 2.5,P < 0.001) 和D2 (20.6 ± 7.7 vs 5.8 ± 3.4,P < 0.001)上皮内淋巴细胞计数增加。研究同时发现,FD患者中幽门螺杆菌感染与D1上皮内淋巴细胞计数增加相关。

研究发现,功能性消化不良患者麸质饮食频率及数量增加,可导致早期饱腹等不适症状,组织上引发肠上皮屏障功能障碍和粘膜免疫激活造成幽门螺杆菌易感。

原始出处:


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    2018-12-05 许安
  3. 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    2018-08-15 0348

    结果不是很可靠

    0

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    2018-01-04 大爰

    学习了谢谢分享!!

    0

  7. 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    2018-01-01 gwc384
  8. 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  9. 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    2017-12-31 lou.minghong

    显而易见的事实.还要研究一番.

    0

  10. 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    2017-12-30 雅文博武

    学习了很多先进的医疗技术

    0

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