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J Invest Dermatol:晒伤了怎么办,维生素D能帮忙!

2017-07-08 Emma 来宝网

最近发表在《the Journal of Investigative Dermatology》期刊的一项研究显示,在晒伤后1小时服用大剂量的维生素D可显着减少皮肤发红、肿胀和发炎。

最近发表在《the Journal of Investigative Dermatology》期刊的一项研究显示,在晒伤后1小时服用大剂量的维生素D可显着减少皮肤发红、肿胀和发炎。

在这项双盲、安慰剂为对照的临床试验中,20名参与者随机分组,手臂经过1小时的UV灯照射后,分别接受安慰剂或50000、100000、200000IU的维生素D治疗。研究者分别在24小时、48小时、72小时和1周后对参与者进行随访,研究者发现,与安慰剂组的参与者相比,服用高剂量维生素D的参与者的症状更轻,在晒伤48小时后,皮肤的炎症反应更轻。而血液中维生素D水平最好的参与者,皮肤发红的情况也最轻。

“我们发现,维生素D的这种效应是剂量依赖性的,”该研究的作者助理教授Kurt Lu说道。“我们之前的假说是,维生素D通过降低炎症反应来促进皮肤的保护性屏障作用。我们没有预料到的是,某个剂量下的维生素D不仅能抑制炎症,还能激活皮肤修复基因。”

这项临床试验第一次描述了维生素D的抗炎作用。作者认为,尽管全世界都在关注维生素D的缺乏问题,但是仍缺乏证据显示采用维生素D干预可解决急性炎症问题。通过在活检样本中检测基因的或许,研究者同时发现,维生素D协助皮肤修复的内在机制。该研究结果显示,维生素D可增加抗炎酶精氨酸酶-1(arginase-1)在皮肤中的水平。精氨酸酶-1可增强皮肤在受到损伤后的修复能力,激活其他抗消炎的蛋白质。

这项研究可能会驱使人们过分关注补充维生素D。本研究中所采用的剂量已经大大地超过了日常的需要量。美国食品药品监督管理局建议的每日维生素D的摄入量为400IU。作者说道,他不建议人们仅根据该研究而在晒伤后大量补充维生素D,但是这项研究结果很有希望,并且值得进行进一步的研究。

原始出处:

Jeffrey F. Scott, Lopa M. Das, et al. Oral vitamin D rapidly attenuates inflammation from sunburn: an interventional study. Journal of Investigative Dermatology. Available online 30 May 2017

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    2017-07-08 laoli

    学习了,谢谢分享!

    0

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    2017-07-08 139****5926

    好好文章学习了

    0

  4. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 08 09:16:07 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219865, encodeId=809721986557, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Jul 08 09:05:49 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219841, encodeId=ffee219841f1, content=好好学习来感谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sat Jul 08 08:41:53 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 lyh994

    这个很有意思!

    0

  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sat Jul 08 08:41:53 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 flysky120

    维生素D以后注意

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sat Jul 08 08:41:53 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 半夏微凉

    谢谢分享,学习了

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sat Jul 08 08:41:53 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 中医痴

    不错的,学习了,谢谢分享!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2050761, encodeId=7f262050e6162, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sun Feb 04 07:04:00 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220093, encodeId=fa242200937b, content=学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 08 09:16:07 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219865, encodeId=809721986557, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Jul 08 09:05:49 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219841, encodeId=ffee219841f1, content=好好学习来感谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sat Jul 08 08:41:53 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 1e0f8808m18(暂无匿称)

    好文章,学习了。

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sat Jul 08 08:41:53 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 明月清辉

    谢谢分享,学习了

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 08 09:16:07 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219865, encodeId=809721986557, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Jul 08 09:05:49 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219841, encodeId=ffee219841f1, content=好好学习来感谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sat Jul 08 08:41:53 CST 2017, time=2017-07-08, status=1, ipAttribution=)]
    2017-07-08 zwjnj2

    好好学习来感谢梅斯

    0

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美国科学家的一项新研究指出,年轻人更容易被晒伤。特别是那些皮肤中的黑色素含量过高的年轻人,被晒伤的风险大大增加。研究人员呼吁年轻人需要制定合理的防晒计划,以预防皮肤癌的发生。

BMJ:住院病人为何会出现晒伤?

下面这名患者因心脏衰竭接受住院治疗,季节是夏季,病床位置处于病房靠窗处。但是在患者住院接受治疗的期间,其左侧手臂处出现日益严重的红斑,最后发展为水疱(如下图所示)。

J Am Acad Dermatol:前次非黑素瘤皮肤癌的成年人更容易实践防晒

与既往无皮肤癌的患者相比,前次非黑素瘤皮肤癌的成年人更容易实践防晒。研究人员对758名前次非黑素瘤皮肤癌(NMSC)患者和34,161名非NMSC患者,受访者被问到他们在阴凉处呆多久,戴着一顶帽子遮住他们的脸、耳朵和脖子多长时间,穿长袖衬衫多长时间,如果外面的温暖,阳光灿烂超过1小时,他们是否使用防晒霜。前次NMSC与非NMSC相比,呆阴凉处(44.3% vs.27%)、长袖(20.5% vs.7

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