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Innate Immun：唾液生物标志物与牙周参数和牙周炎风险相关

2018-09-06 MedSci MedSci原创

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遗传因素在牙周炎中起作用。在这里，我们检查了MHC III类区域BAT1-NFKBIL1-LTA和淋巴毒素-α多态性的风险单倍型是否与牙周病的唾液生物标志物相关。研究共纳入了455名具有详细的临床和放射学牙周健康数据的患者。610 K基因分型芯片和Sequenom平台用于基因分型分析。在唾液样品中检查磷脂转移蛋白活性，淋巴毒素-α，IL-8和髓过氧化物酶的浓度，以及累积风险评分（包括牙龈卟啉单胞菌

遗传因素在牙周炎中起作用。在这里，我们检查了MHC III类区域BAT1-NFKBIL1-LTA和淋巴毒素-α多态性的风险单倍型是否与牙周病的唾液生物标志物相关。

研究共纳入了455名具有详细的临床和放射学牙周健康数据的患者。610 K基因分型芯片和Sequenom平台用于基因分型分析。在唾液样品中检查磷脂转移蛋白活性，淋巴毒素-α，IL-8和髓过氧化物酶的浓度，以及累积风险评分（包括牙龈卟啉单胞菌，IL-1β和基质金属蛋白酶-8的水平）。

结果显示，升高的IL-8和髓过氧化物酶浓度与晚期牙齿缺失、牙周袋加深和牙周炎症相关的累积风险评分相关。在校正牙周参数和风险因子的多个逻辑回归模型中，髓过氧化物酶浓度（优势比（OR）; 1.37，P = 0.007）与具有其遗传变体rs2857708，rs2009658和rs2844482的风险单倍型和淋巴毒素-α浓度的风险增加相关。

总之，唾液中IL-8、髓过氧化物酶和累积风险评分与牙周炎症和组织破坏有关，而髓过氧化物酶和淋巴毒素-α的唾液水平也与遗传因素相关。

原始出处：

Liukkonen J, Gürsoy UK, et al., Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype. Innate Immun. 2018 Sep 3:1753425918796207. doi: 10.1177/1753425918796207.

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    2019-02-18 hukaixun

    #标志物#

    0

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    2018-10-29 liye789132251

    #Nat#

    0

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    2019-04-29 mhzhuang@stu.e

    #牙周参数#

    0

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    2018-09-07 liuyong2982

    #牙周#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1841292, encodeId=bad5184129256, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon Feb 18 20:47:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883290, encodeId=3ff3188329026, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Oct 29 19:47:00 CST 2018, time=2018-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949439, encodeId=05ec1949439f2, content=<a href='/topic/show?id=16d16e5034c' target=_blank style='color:#2F92EE;'>#牙周参数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67503, encryptionId=16d16e5034c, topicName=牙周参数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Mon Apr 29 09:47:00 CST 2019, time=2019-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450995, encodeId=a26e1450995be, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri Sep 07 15:47:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560769, encodeId=d45c1560e6964, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Sep 07 15:47:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566778, encodeId=d20c1566e78d4, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Sep 07 15:47:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343227, encodeId=7b6b34322e6f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Thu Sep 06 07:51:18 CST 2018, time=2018-09-06, status=1, ipAttribution=)]
    2018-09-07 zhu_jun9842

    #生物标志#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1841292, encodeId=bad5184129256, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon Feb 18 20:47:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883290, encodeId=3ff3188329026, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Oct 29 19:47:00 CST 2018, time=2018-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949439, encodeId=05ec1949439f2, content=<a href='/topic/show?id=16d16e5034c' target=_blank style='color:#2F92EE;'>#牙周参数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67503, encryptionId=16d16e5034c, topicName=牙周参数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Mon Apr 29 09:47:00 CST 2019, time=2019-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450995, encodeId=a26e1450995be, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri Sep 07 15:47:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560769, encodeId=d45c1560e6964, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Sep 07 15:47:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566778, encodeId=d20c1566e78d4, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Sep 07 15:47:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343227, encodeId=7b6b34322e6f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Thu Sep 06 07:51:18 CST 2018, time=2018-09-06, status=1, ipAttribution=)]
    2018-09-07 zhu_jun9842

    #生物标志#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1841292, encodeId=bad5184129256, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon Feb 18 20:47:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883290, encodeId=3ff3188329026, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Oct 29 19:47:00 CST 2018, time=2018-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949439, encodeId=05ec1949439f2, content=<a href='/topic/show?id=16d16e5034c' target=_blank style='color:#2F92EE;'>#牙周参数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67503, encryptionId=16d16e5034c, topicName=牙周参数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Mon Apr 29 09:47:00 CST 2019, time=2019-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450995, encodeId=a26e1450995be, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri Sep 07 15:47:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560769, encodeId=d45c1560e6964, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Sep 07 15:47:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566778, encodeId=d20c1566e78d4, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Sep 07 15:47:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343227, encodeId=7b6b34322e6f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Thu Sep 06 07:51:18 CST 2018, time=2018-09-06, status=1, ipAttribution=)]
    2018-09-06 phoebeyan520

    学习了

    0

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