Radiology：将节约进行到底！减少18F-FDG剂量在临床PET/MR成像的应用

2017-10-06 shaosai MedSci原创

葡萄糖是人体三大能源物质之一，将可以被PET探测并形成影像的的正电子核素18F标记在葡萄糖上，即18F-脱氧葡萄糖(18FDG)。因为18FDG可准确反映体内器官/组织的葡萄糖代谢水平，因此被誉为"世纪分子"，是目前PET-CT显像的主要显像剂。恶性肿瘤细胞由于代谢旺盛，导致对葡萄糖的需求增加，因此静脉注射葡萄糖类似物--18FDG后，大多数肿瘤病灶会表现为对18FDG的高摄取，因此可应用18FD

葡萄糖是人体三大能源物质之一，将可以被PET探测并形成影像的的正电子核素18F标记在葡萄糖上，即18F-脱氧葡萄糖(18FDG)。因为18FDG可准确反映体内器官/组织的葡萄糖代谢水平，因此被誉为"世纪分子"，是目前PET-CT显像的主要显像剂。恶性肿瘤细胞由于代谢旺盛，导致对葡萄糖的需求增加，因此静脉注射葡萄糖类似物--18FDG后，大多数肿瘤病灶会表现为对18FDG的高摄取，因此可应用18FDG PET-CT显像可早期发现全身肿瘤原发及转移病灶，准确判断其良、恶性，从而正确指导临床治疗决策。

本研究旨在验证利用硅光电倍增管探测器（SiPM）进行时间飞跃法-正电子发射体层成像（PET）/磁共振（MR）成像中临床所能接受的注射氟18-氟脱氧葡萄糖（F18-FDG）的剂量，并与TOF-PET/计算机体层成像（CT）Lu1.8Y0.2SiO5(Ce)或LYSO探测器进行比较在不公体质指数患者中的效果，并将结果发表在Radiology上。

本研究共纳入了74例具有不同恶性肿瘤的患者，并行连续全身TOF-PET/CT和TOF-PET/MR成像。提取注射不同剂量18F-FDG下的PET图像。有两名阅片者对全身图像质量进行评级，以及每一部位的图像质量，然后评价恶性肿瘤的显示质量。

结果为，注射剂量为70%或60%18F-FDG PET/MR的图像质量与PET/CT的图像质量相似。在注射剂量为50%时，仅在BMI低于25 kg/m2的恶性肿瘤患者中图像质量尚能维持一致。与有TOF重建的PET图像相比，在无TOF重建的PET图像会出现较高的伪影评分和锐利度减弱。

本研究表明，对BMI超过25 kg/m2患者利用SiPM探测器进行TOF-PET/MR成像时，将18F-FDG注射剂量降到60%（减少40%）仍能达到满足临床需要的PET图像质量。另外，对BMI低于25 kg/m2患者，注射50%的剂量仍能获得满意的图像质量。

原始出处：

Sekine T， Delso G， Zeimpekis KG， et al，Reduction of 18F-FDG Dose in Clinical PET/MR Imaging by Using Silicon Photomultiplier Detectors. Radiology. 2017.DOI： 10.1148/radiol.2017162305

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2018-08-22 xugumin

#8F-FDG#

78 0
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2017-11-11 feather89

#PE#

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2017-10-08 ms7514935887898259

#PET#

95 0
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2017-10-07 1e1b8538m79(暂无匿称)

不错的文章值得一读.

142 0
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2017-10-07 131****2916

不错的文章值得推荐

97 0
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2017-10-07 明月清辉

谢谢分享.学习了

132 0
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2017-10-07 龙胆草

学习谢谢分享

136 0
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2017-10-07 yjs木玉

受益匪浅.认真学习

149 0
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2017-10-07 飛歌

学习了很有用

113 0
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content=葡萄糖是人体三大能源物质之一.将可以被PET探测并形成影像的的正电子核素18F标记在葡萄糖上.即18F-脱氧葡萄糖(18FDG).因为18FDG可准确反映体内器官/组织的葡萄糖代谢水平.因此被誉为"世纪分子".是目前PET-CT显像的主要显像剂, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Oct 06 22:47:26 CST 2017, time=2017-10-06, status=1, ipAttribution=)]
2017-10-06 有备才能无患

葡萄糖是人体三大能源物质之一.将可以被PET探测并形成影像的的正电子核素18F标记在葡萄糖上.即18F-脱氧葡萄糖(18FDG).因为18FDG可准确反映体内器官/组织的葡萄糖代谢水平.因此被誉为"世纪分子".是目前PET-CT显像的主要显像剂

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