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Diabetes Obes Metab:降糖药信得过吗?强化血糖控制可能使你面临什么风险?

2017-11-16 sunshine2015 来宝网

加的夫大学的一项研究发现,强化血糖控制以达到2型糖尿病低血糖目标的常见方法可能会增加死亡风险。

强烈的血糖控制可能有不良影响】加的夫大学的一项研究发现,强化血糖控制以达到2型糖尿病低血糖目标的常见方法可能会增加死亡风险。

研究人员从2004年到2015年收集到的英国超过30万人的常规数据发现,与中等水平相比,较低水平的糖化血红蛋白(通常被认为是良好的糖尿病控制)与死亡风险增加相关可能导致低血糖的强化治疗。

卡迪夫大学医学院的克雷格·柯里(Craig Currie)教授说:“治疗指南通常建议以低血糖控制为目标的治疗策略,理解为降低冠状动脉疾病和中风等大血管并发症的风险,与此相反,我们的研究结果有说服力地指出,死亡率增加与血糖控制良好或HbA1c低有关。

研究结果还表明,既没有随机试验也没有观察性研究能够证明血糖控制水平和不良结果之间存在一致的关联模式,没有解释为什么。因此,2型糖尿病患者血糖控制的最佳目标仍不确定。此外,与葡萄糖控制有关的死亡率模式与不同类型的糖尿病药物相关。最令人担忧的是对那些接受胰岛素和其他降低血糖药物治疗的2型糖尿病患者“控制良好”的死亡风险增加。

柯里教授说:“一些降血糖药物的安全性仍然存在严重问题,科学证据和反对意见在很大程度上被忽视。”

“糖尿病,肥胖和代谢”杂志发表了“不同降糖方案对葡萄糖控制和生存之间关系模式的影响”的研究。

原始出处:

Craig J. Currie et al. The impact of differing glucose-lowering regimens on the pattern of association between glucose control and survival. Diabetes, Obesity and Metabolism (2017). DOI: 10.1111/dom.13155.

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    2018-05-29 一闲
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    2018-04-08 guojianrong
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    2017-11-16 1e0f8808m18(暂无匿称)

    降糖需慎重.避免低血糖.

    0

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