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JNCI: 冷冻疗法可预防化疗引起的神经病变

2017-10-21 MedSci MedSci原创

根据10月12日发表在《国家癌症研究所杂志》(Journal of the National Cancer Institute)上的一项研究,冷冻疗法可能有助于预防化疗引起的周围神经病变(CIPN)的症状。CIPN是紫杉醇类抗癌药物所引起的剂量依赖性并发症。日本京都大学的Akiko Hanai,O.T.R.及其同事评估了36例乳腺癌患者在每周接受紫杉醇治疗(80mg / m2,1小时)的过程中采用


根据10月12日发表在《国家癌症研究所杂志》(Journal of the National Cancer Institute)上的一项研究,冷冻疗法可能有助于预防化疗引起的周围神经病变(CIPN)的症状。CIPN是紫杉醇类抗癌药物所引起的剂量依赖性并发症。

日本京都大学的Akiko Hanai,O.T.R.及其同事评估了36例乳腺癌患者在每周接受紫杉醇治疗(80mg / m2,1小时)的过程中采用冷冻治疗法对预防CIPN的疗效。受试者穿戴冰冻的手套和袜子持续90分钟,包括药物注射的整个时间。

主要终点是通过在960mg / m 2的累积剂量下的单纤维试验中由预处理基线的触觉敏感性的变化评估的CIPN发生率。我们还通过PNQ评估热敏感缺陷,主观症状(患者神经病调查问卷[PNQ]),手术灵巧度,事件发生时间和风险比。 所有的统计测试都是双面的。

在40例患者中,4例未达到累积剂量(由于发生肺炎,严重疲劳,严重肝功能不全和黄斑水肿),剩下36名患者进行分析。 没有因冷冻不耐受而退出。干预组与对照组比较,客观和主观的CIPN体征的发生率在临床和统计学上均明显低于对照组。这种方法适用于手部触觉敏感性(优势比[OR],20;95%置信区间[CI],3.2到828.96;P < 0.001),足部触觉敏感(OR,无穷大;95% CI,3.32到无限;P < 0.001),手温感觉(OR,9;95% CI,1.25到394.48;P = 0.02),脚温感(OR,5;95% CI,1.07到46.93;P = 0.04),手部病人神经病变问卷(PNQ;OR,无穷大;95% CI,3.32到无穷大;P < 0.001),脚PNQ(OR,无穷大;95% CI,2.78到无无穷大;P < 0.001)。

作者总结说:"冷冻治疗对于预防CIPN的客观和主观症状以及由此产生的功能障碍都是有用的。


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    2017-10-25 lucycici

    学习了.谢谢

    0

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    2017-10-23 axin012
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    2017-10-21 半夏微凉

    学习了谢谢分享

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