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J Natl Cancer Inst:含糖饮料摄入过多可增加胆囊癌的发生风险

2016-07-09 MedSci MedSci原创

研究已经表明摄入含糖饮料可升高血糖浓度,且与体重增加和2型糖尿病的发生密切相关,而这些都与胆道癌(BTC)的发生相关。本研究假设含糖饮料的消费量与BTC的发生风险成正相关。研究共70832名瑞典成人(55.9%为男性,年龄45-83年),均未患有癌症和糖尿病,基线时期完成了食物频率调查问卷。通过瑞典癌症登记册确定BTC病例。使用Cox比例风险回归模型来分析数据。在平均13.4年的随访期间,共有12

研究已经表明摄入含糖饮料可升高血糖浓度,且与体重增加和2型糖尿病的发生密切相关,而这些都与胆道癌(BTC)的发生相关。本研究假设含糖饮料的消费量与BTC的发生风险成正相关。

研究共70832名瑞典成人(55.9%为男性,年龄45-83年),均未患有癌症和糖尿病,基线时期完成了食物频率调查问卷。通过瑞典癌症登记册确定BTC病例。使用Cox比例风险回归模型来分析数据。

在平均13.4年的随访期间,共有127名患者发生肝外BTC(包括71名胆囊癌)和21名患者发生肝内BTC。校正其他危险因素后发现摄入含糖饮料水平最高的参与者其肝外BTC和胆囊癌的发生风险明显升高。与不摄入含糖饮料的参与者相比,每天摄入两种(200 毫升/每种)及以上含糖饮料的参与者的多变量风险比分别为1.79(肝外BTC,95% CI = 1.02-3.13)和2.24(胆囊癌,95% CI = 1.02-4.89)。肝内BTC的风险比为1.69(95% CI = 0.41-7.03)。

总而言之,该研究结果支持摄入高水平的加糖饮料可能会增加BTC的风险,尤其是胆囊癌。

原始出处:

Susanna C. Larsson, Edward L. Giovannucci, Alicja Wolk. Sweetened Beverage Consumption and Risk of Biliary Tract and Gallbladder Cancer in a Prospective Study. J Natl Cancer Inst. 2016;doi;10.1093/jnci/djw125.


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    2016-11-13 drj2003
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    2016-08-23 liye789132251
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    2016-11-01 qidongfanjian
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    2016-08-05 Mr.Li先生

    糖类摄入过多也不好

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1977517, encodeId=db5519e75171d, content=<a href='/topic/show?id=d9e5130962f' target=_blank style='color:#2F92EE;'>#NST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13096, encryptionId=d9e5130962f, topicName=NST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Sun Nov 13 21:57:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1881161, encodeId=9c5318811614f, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Aug 23 13:57:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950183, encodeId=b175195018300, content=<a href='/topic/show?id=f3b329482a' target=_blank style='color:#2F92EE;'>#ATL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2948, encryptionId=f3b329482a, topicName=ATL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Tue Nov 01 14:57:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96091, encodeId=5c2d96091e2, content=糖类摄入过多也不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri Aug 05 11:08:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96092, encodeId=96f9960925b, content=糖类摄入过多也不好啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri Aug 05 11:08:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96093, encodeId=6c2d9609358, content=还是少摄入, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri Aug 05 11:08:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93166, encodeId=8e8193166a3, content=糖类的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 16 07:51:00 CST 2016, time=2016-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1315176, encodeId=7b6213151e663, content=<a href='/topic/show?id=11788344565' target=_blank style='color:#2F92EE;'>#胆囊癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83445, encryptionId=11788344565, topicName=胆囊癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Mon Jul 11 12:57:00 CST 2016, time=2016-07-11, status=1, ipAttribution=)]
    2016-08-05 Mr.Li先生

    糖类摄入过多也不好啊

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1977517, encodeId=db5519e75171d, content=<a href='/topic/show?id=d9e5130962f' target=_blank style='color:#2F92EE;'>#NST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13096, encryptionId=d9e5130962f, topicName=NST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Sun Nov 13 21:57:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1881161, encodeId=9c5318811614f, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Aug 23 13:57:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950183, encodeId=b175195018300, content=<a href='/topic/show?id=f3b329482a' target=_blank style='color:#2F92EE;'>#ATL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2948, encryptionId=f3b329482a, topicName=ATL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Tue Nov 01 14:57:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96091, encodeId=5c2d96091e2, content=糖类摄入过多也不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri Aug 05 11:08:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96092, encodeId=96f9960925b, content=糖类摄入过多也不好啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri Aug 05 11:08:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96093, encodeId=6c2d9609358, content=还是少摄入, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri Aug 05 11:08:00 CST 2016, time=2016-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93166, encodeId=8e8193166a3, content=糖类的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Jul 16 07:51:00 CST 2016, time=2016-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1315176, encodeId=7b6213151e663, content=<a href='/topic/show?id=11788344565' target=_blank style='color:#2F92EE;'>#胆囊癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83445, encryptionId=11788344565, topicName=胆囊癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Mon Jul 11 12:57:00 CST 2016, time=2016-07-11, status=1, ipAttribution=)]
    2016-08-05 Mr.Li先生

    还是少摄入

    0

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    2016-07-16 oo902

    糖类的作用

    0

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