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29%新冠病毒样本出现D614G变异,感染力增强2.6倍

2020-07-04 MedSci原创 MedSci原创

当地时间3日,针对有实验室研究发现新冠病毒D614G变异可能导致病毒加速复制和加强其传播性,世卫组织官员表示:研究显示29%的新冠病毒样本都出现了该变异;这不是新的变异,带有该变异的病毒已在欧洲及美洲

当地时间3日,针对有实验室研究发现新冠病毒D614G变异可能导致病毒加速复制和加强其传播性,世卫组织官员表示:研究显示29%的新冠病毒样本都出现了该变异;这不是新的变异,带有该变异的病毒已在欧洲及美洲传播;但目前并无证据显示其会导致更严重的病情。

新冠病毒D614G变异可能加强病毒传播性

世卫组织首席科学家苏米娅·斯瓦米纳坦表示,实验室研究发现,新冠病毒D614G变异可能导致病毒加速复制,意味着可能加强其传播性。但实验室结果同病毒在实际传播中发生的变化间,还有很大区别,科学家已对该变异进行监测。

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世卫组织首席科学家苏米娅·斯瓦米纳坦

世卫组织卫生紧急项目技术主管玛丽亚·范·科霍夫表示,其实二月份就已发现D614G变异,欧洲等地发现的早期病毒基因序列中就已出现该变异,有研究显示29%的新冠病毒样本都出现了该变异,但目前并无证据显示其会导致更严重的病情。

5effb752e4b086b2fe0f6e0b.jpeg?x-oss-process=style/w10

世卫组织卫生紧急项目技术主管玛丽亚·范·科霍夫

截至目前,围绕新冠病毒D614G突变的研究和争议最多。白宫卫生顾问安东尼·福奇美国当地时间7月2日也表示,新冠病毒已经发生变异,可能会让病原体变得更容易传播。就在同日,闻名全球的美国洛斯阿拉莫斯国家实验室(Los Alamos National Laboratory)、杜克人类疫苗研究所和外科系、英国谢菲尔德大学等团队的研究人员在顶级学术期刊《细胞》(Cell)在线发表了一项研究,题为“Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus ”。他们的研究结果认为:携带S蛋白D614G的SARS-CoV-2突变株已成为全球大流行中最普遍的形式。

研究团队对变异频率的动态跟踪显示,G614在国家、地区和城市等多个地理级别上呈现反复增长模式。即使此前已经确定了D614型为主导地位的地区,D614向G614的转变也会发生。他们认为,这一模式的一致性具有高度的统计意义,表明G614变异可能具有适应性优势。

研究团队还发现,相比突变前,更高的病毒载量提示D614G突变病毒和患者上呼吸道病毒核酸水平较高相关。但论文同时指出,“我们发现D614G和疾病严重程度之间没有显著关联。”研究团队还提出,G614突变假病毒与较高的传染性有关,量化分析得出,携带G614突变的病毒颗粒比对应的D614具有明显更高的感染性滴度,增加2.6至9.3倍,并在多种细胞类型中证实。

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    2021-02-23 zhzhxiang
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    2020-07-04 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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