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Diabetes Care:严重低血糖或与2型糖尿病患者癌症发生率较高相关

2014-02-13 晓静 编译 医学论坛网

中国香港学者探讨了2型糖尿病患者发生严重低血糖的临床情况与其临床转归(包括死亡和所有部位癌症发生)的相关性,结果表明,严重低血糖与高龄、肾功能不全、血糖控制不佳和癌症亚表现[低体质指数(BMI)、低水平的低密度脂蛋白胆固醇(LDL-C)和低甘油三酯(TG)]存在相关性。论文2月10日在线发表于《糖尿病护理》(Diabetes Care)杂志。【原文下载】 研究纳入8767例在入组前的12

中国香港学者探讨了2型糖尿病患者发生严重低血糖的临床情况与其临床转归(包括死亡和所有部位癌症发生)的相关性,结果表明,严重低血糖与高龄、肾功能不全、血糖控制不佳和癌症亚表现[低体质指数(BMI)、低水平的低密度脂蛋白胆固醇(LDL-C)和低甘油三酯(TG)]存在相关性。论文2月10日在线发表于《糖尿病护理》(Diabetes Care)杂志。【原文下载】

研究纳入8767例在入组前的12个月内有或无严重低血糖的2型糖尿病患者。利用Cox比例风险模型计算严重低血糖的危险比(HR)和95%置信区间(Cis)。

结果显示,在研究队列中,患者的平均年龄为57.4岁,糖尿病中位患病时间为5年。在平均随访的6.71年间,有235例患者发生了严重低血糖(发生率为3.96例/1000人-年)。在入组时,有或无严重低血糖的患者癌症发生率相似。但在随访期间,与无严重低血糖的患者相比,有严重低血糖的患者所有部位癌症发生率(13.4 对6.4%,P< 0.0001)和死亡率(32.8对11.2%,P < 0.0001)均较高。校正混淆因素后,高龄、低BMI、高糖化血红蛋白、低TG、低LDL-C、蛋白尿和慢性肾病是严重低血糖的独立预测因素。

原始出处:

Kong AP, Yang X, Luk A, Ma RC, So WY, Ozaki R, Ting R, Cheung K, Ho CS, Chan MH, Chow CC, Chan JC.Severe Hypoglycemia Identifies Vulnerable Patients With Type 2 Diabetes at Risk for Premature Death and All-Site Cancer: The Hong Kong Diabetes Registry.Diabetes Care. 2014 Feb 10. 【原文下载】


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    2014-06-29 智智灵药
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睡眠障碍性呼吸和困倦导致代谢、认知和行为障碍。睡眠障碍性呼吸在2型糖尿病中是比较常见的,该疾病要求患者坚持复杂的饮食、行为和药物治疗方案。低血糖是治疗过程中一个重要的副反应,它能够导致生理和心理的伤害,同时使最佳的血糖控制难以达标。因此,为了研究睡眠障碍与低血糖风险的相关性,来自英国爱丁堡皇家医院糖尿病科的Inkster等进行了一项研究,表明白天困倦可能是一个新颖的

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2型糖尿病患者处于增高的老年认知减退和痴呆的风险中。低血糖是其中的一个候选危险因素,但是严重低血糖事件与2型糖尿病患者认知减退的相关性尚未明确。因此,来自爱丁堡大学人口健康科学中心的Feinkohl等进行了一项研究,发现低血糖与老年T2DM患者认知减退有关。研究结果在线发表于2013年10月8日的美国《糖尿病治疗》(Diabetes Care)杂志上。【原文下载】 在

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