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Aliment Pharm Ther: 适度喝咖啡,就可以降低近一半的肝病死亡率?

2020-09-01 王木木 生物探索

肝病是导致人类健康的杀手之一,据统计,全球每年约超过100万人死于肝硬化,约七十四万人因肝硬化引发的肝癌死亡,占每年总死亡人数的3.5%以上。

肝病是导致人类健康的杀手之一,据统计,全球每年约超过100万人死于肝硬化,约七十四万人因肝硬化引发的肝癌死亡,占每年总死亡人数的3.5%以上。为了减少这种疾病的发生和治疗负担,各国均开展了针对乙肝和丙肝的疫苗接种和多种治疗策略。

近日,来自澳大利亚墨尔本大学和圣文森特医院的研究人员通过一项研究,发现人均咖啡摄入量增加对全球肝脏相关死亡率的降低具有有益影响,如果世界上每个人每天至少喝两杯咖啡,那么因肝癌而死亡的人数将减少数十万。相关研究成果发表在《Alimentary

Pharmacology & Therapeutics》上。

https://doi.org/10.1111/apt.16020

在这项研究中,研究人员统计了全球疾病负担 (GBD)数据库中2016年各个国家的肝脏相关疾病和乙型肝炎引起的15岁以上的死亡人数,使用了国际咖啡组织的公开数据统计了每个国家的人均年度咖啡消费量。然后将这两组数据添加到一个模型中,以估算人均咖啡摄入量增加对全球肝脏相关死亡率的潜在影响。

统计的人均每天咖啡摄入量的全球地图

经统计,全球范围内,2016年15岁以上人群中约发生了124万例肝脏相关疾病死亡,肝病死亡率中位数为每10万人每年15例死亡。结合咖啡消费量,该模型显示,如果全球人均咖啡每天饮用超过两杯,则在15岁以上的人群中,与肝脏相关的死亡总数至少会减少到约71.5万例,避免了约42%的死亡,人口可预防比率为每年每10万人中可预防7.8例肝脏相关死亡。

2016年各地区人均咖啡消费量的肝脏相关死亡的实际数量和每天超过两杯或四杯的预测肝脏相关死亡数量

而如果所有国家/地区的人均咖啡摄入量增加到每天四杯或更多,那么全球死亡总数至少会降低将40万,并且可以避免67%例与肝脏有关的死亡,人口可预防的比率将能达到每年每10万人中预防12.1例肝脏相关死亡。

实际上,近年来人们已经逐渐发现,饮用咖啡可以改善肝脏的生物化学,并且减缓肝硬化的发展。2015年《Gastroenterology》发布的一项迄今为止最大规模的高质量前瞻性队列研究提到,每天喝2到3杯的咖啡可以使肝硬化的患病风险降低38%,死于该疾病的风险降低46%,当每天喝4杯咖啡或更多量时,肝硬化风险会降低41%,其死亡风险则会降低71%。

总之,这项研究表明,如果在全球范围内普遍鼓励适度喝咖啡,以减少因肝病导致的过早死亡的风险,则每年可以挽救一百万人的生命。尤其是在咖啡饮量低且潜在肝病发病率相对较高的欧洲以外的其他地区,其获取的与肝脏有关的死亡率收益会更大。

原始出处:Paul GowTim SpelmanSarah Gardner, et al. Estimates of the global reduction in liver disease‐related mortality with increased coffee consumption: an analysis of the Global Burden of Disease Dataset. Alimentary Pharmacology & Therapeutics. 14 August 2020

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    2020-10-15 jj000001
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    2021-04-27 ms2000001361349190

    日常必喝

    0

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encryptionId=ca2910385381, topicName=代谢相关性肝病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Sep 01 20:29:10 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881827, encodeId=0afa88182e82, content=喝一定量的咖啡确实有好处, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/icLAWkJCK7qiaEesKXugHe7j9KdIuA0H6Hqq6Jgz8alianumGnI9JTGiaIPyxIDHm132G8Mt9t8aT9WeoqIicaTmF5w/132, createdBy=553a2149451, createdName=琳紫, createdTime=Tue Sep 01 16:42:45 CST 2020, time=2020-09-01, status=1, ipAttribution=)]
    2020-09-14 ms8000000196949374

    0

  4. 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    2020-09-08 ggdhs

    学习了

    0

  5. 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encryptionId=ca2910385381, topicName=代谢相关性肝病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Sep 01 20:29:10 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881827, encodeId=0afa88182e82, content=喝一定量的咖啡确实有好处, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/icLAWkJCK7qiaEesKXugHe7j9KdIuA0H6Hqq6Jgz8alianumGnI9JTGiaIPyxIDHm132G8Mt9t8aT9WeoqIicaTmF5w/132, createdBy=553a2149451, createdName=琳紫, createdTime=Tue Sep 01 16:42:45 CST 2020, time=2020-09-01, status=1, ipAttribution=)]
    2020-09-02 cmuwisdom

    谢谢学习了

    0

  6. 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GetPortalCommentsPageByObjectIdResponse(id=881852, encodeId=42e088185268, content=饮用<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>可以改善肝脏的生物化学,并且减缓<a href='/topic/show?id=cb65813029a' target=_blank style='color:#2F92EE;'>#肝硬化#</a>的发展,这要看具体情况了。对于<a href='/topic/show?id=cf292341925' target=_blank style='color:#2F92EE;'>#乙肝#</a>导致的肝硬化,可能咖啡不会有作用的。但是,对于<a href='/topic/show?id=85d999e268a' target=_blank style='color:#2F92EE;'>#非酒精性脂肪肝#</a>,现在叫<a href='/topic/show?id=ca2910385381' target=_blank style='color:#2F92EE;'>#代谢相关性肝病#</a>,咖啡可能真的有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=365, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡), TopicDto(id=81302, encryptionId=cb65813029a, topicName=肝硬化), TopicDto(id=23419, encryptionId=cf292341925, topicName=乙肝), TopicDto(id=99726, encryptionId=85d999e268a, topicName=非酒精性脂肪肝), TopicDto(id=103853, encryptionId=ca2910385381, topicName=代谢相关性肝病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Sep 01 20:29:10 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881827, encodeId=0afa88182e82, content=喝一定量的咖啡确实有好处, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/icLAWkJCK7qiaEesKXugHe7j9KdIuA0H6Hqq6Jgz8alianumGnI9JTGiaIPyxIDHm132G8Mt9t8aT9WeoqIicaTmF5w/132, createdBy=553a2149451, createdName=琳紫, createdTime=Tue Sep 01 16:42:45 CST 2020, time=2020-09-01, status=1, ipAttribution=)]
    2020-09-02 14818eb4m67暂无昵称

    学习

    0

  7. 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content=谢谢学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d30104504, createdName=cmuwisdom, createdTime=Wed Sep 02 15:52:41 CST 2020, time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=882012, encodeId=2749882012df, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Wed Sep 02 08:07:00 CST 2020, time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881901, encodeId=25328819013b, content=喜欢喝<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>,又为喝咖啡找到了一个好的理由。, beContent=null, objectType=article, channel=null, 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encryptionId=ca2910385381, topicName=代谢相关性肝病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Sep 01 20:29:10 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881827, encodeId=0afa88182e82, content=喝一定量的咖啡确实有好处, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/icLAWkJCK7qiaEesKXugHe7j9KdIuA0H6Hqq6Jgz8alianumGnI9JTGiaIPyxIDHm132G8Mt9t8aT9WeoqIicaTmF5w/132, createdBy=553a2149451, createdName=琳紫, createdTime=Tue Sep 01 16:42:45 CST 2020, time=2020-09-01, status=1, ipAttribution=)]
    2020-09-01 Jessica

    喜欢喝#咖啡#,又为喝咖啡找到了一个好的理由。

    0

  8. 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encryptionId=ca2910385381, topicName=代谢相关性肝病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Sep 01 20:29:10 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881827, encodeId=0afa88182e82, content=喝一定量的咖啡确实有好处, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/icLAWkJCK7qiaEesKXugHe7j9KdIuA0H6Hqq6Jgz8alianumGnI9JTGiaIPyxIDHm132G8Mt9t8aT9WeoqIicaTmF5w/132, createdBy=553a2149451, createdName=琳紫, createdTime=Tue Sep 01 16:42:45 CST 2020, time=2020-09-01, status=1, ipAttribution=)]
    2020-09-01 Sunny orchard

    咖啡毕竟是饮品,不可神话其作用

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=881852, encodeId=42e088185268, content=饮用<a href='/topic/show?id=5fae39e738a' target=_blank style='color:#2F92EE;'>#咖啡#</a>可以改善肝脏的生物化学,并且减缓<a href='/topic/show?id=cb65813029a' target=_blank style='color:#2F92EE;'>#肝硬化#</a>的发展,这要看具体情况了。对于<a href='/topic/show?id=cf292341925' target=_blank style='color:#2F92EE;'>#乙肝#</a>导致的肝硬化,可能咖啡不会有作用的。但是,对于<a href='/topic/show?id=85d999e268a' target=_blank style='color:#2F92EE;'>#非酒精性脂肪肝#</a>,现在叫<a href='/topic/show?id=ca2910385381' target=_blank style='color:#2F92EE;'>#代谢相关性肝病#</a>,咖啡可能真的有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=365, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡), TopicDto(id=81302, encryptionId=cb65813029a, topicName=肝硬化), TopicDto(id=23419, encryptionId=cf292341925, topicName=乙肝), TopicDto(id=99726, encryptionId=85d999e268a, topicName=非酒精性脂肪肝), TopicDto(id=103853, encryptionId=ca2910385381, topicName=代谢相关性肝病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Sep 01 20:29:10 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881827, encodeId=0afa88182e82, content=喝一定量的咖啡确实有好处, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/icLAWkJCK7qiaEesKXugHe7j9KdIuA0H6Hqq6Jgz8alianumGnI9JTGiaIPyxIDHm132G8Mt9t8aT9WeoqIicaTmF5w/132, createdBy=553a2149451, createdName=琳紫, createdTime=Tue Sep 01 16:42:45 CST 2020, time=2020-09-01, status=1, ipAttribution=)]
    2020-09-01 lovetcm

    饮用#咖啡#可以改善肝脏的生物化学,并且减缓#肝硬化#的发展,这要看具体情况了。对于#乙肝#导致的肝硬化,可能咖啡不会有作用的。但是,对于#非酒精性脂肪肝#,现在叫#代谢相关性肝病#,咖啡可能真的有用

    0

  10. 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level=null, likeNumber=278, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39773, encryptionId=5fae39e738a, topicName=咖啡)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Tue Sep 01 22:07:53 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881892, encodeId=8b7788189242, content=咖啡毕竟是饮品,不可神话其作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200901/629d1ce7d6f64d17a642c37c90dea72c/202f9333a3ea4b23a9b07ede3364e86b.jpg, createdBy=1a335163906, createdName=Sunny orchard, createdTime=Tue Sep 01 21:57:19 CST 2020, time=2020-09-01, status=1, ipAttribution=), 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encryptionId=ca2910385381, topicName=代谢相关性肝病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Sep 01 20:29:10 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881827, encodeId=0afa88182e82, content=喝一定量的咖啡确实有好处, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/icLAWkJCK7qiaEesKXugHe7j9KdIuA0H6Hqq6Jgz8alianumGnI9JTGiaIPyxIDHm132G8Mt9t8aT9WeoqIicaTmF5w/132, createdBy=553a2149451, createdName=琳紫, createdTime=Tue Sep 01 16:42:45 CST 2020, time=2020-09-01, status=1, ipAttribution=)]
    2020-09-01 琳紫

    喝一定量的咖啡确实有好处

    0

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