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PLOS Pathog:研究发现:细菌促进结肠直肠癌症的生长

2017-08-21 白木清水 来宝网

最近的一项研究发现,一种细菌能促进结肠直肠癌的生长,而这是导致癌症死亡的第二大原因。



最近的一项研究发现,一种细菌能促进结肠直肠癌的生长,而这是导致癌症死亡的第二大原因

人类的肠道通常会宿主数以万计的微生物。虽然这些微生物对人体健康至关重要,但研究也表明肠道细菌与肠道疾病之间存在着联系,包括结肠直肠癌。

结肠直肠癌是美国癌症相关死亡的第二大原因,每年大约有14万美国人被诊断出患有这种疾病,超过5万人死于这种疾病。

一项新的研究调查了一种名为“链球菌”的链球菌(Sg)和结肠直肠癌之间的联系。

之前的研究已经指出了结肠直肠癌与Sg之间的联系,但是直到现在,还不清楚是什么时候或者是怎样促进了这种情况的发展。

具体来说,目前尚不清楚这种细菌本身是否会主动导致结肠直肠癌,或者,如果癌症肿瘤是治疗Sg发展的有利环境,那么它是否会导致这种疾病的发生。

这项新的研究开始了,研究了可能导致Sg和结肠直肠癌之间联系的确切机制。

这项研究的第一作者是Ritesh Kumar,他是位于布莱恩的德克萨斯农工大学的健康科学中心,这些发现发表在公共科学图书馆病原体杂志上。

链球菌(Sg)积极促进癌症扩散

库玛尔和他的同事们在试管中进行了人体细胞培养和人体肿瘤的研究,并在小鼠身上进行实验。

在细胞培养中,科学家们和Sg一起培养了结肠直肠癌细胞。这些实验表明,Sg有助于结肠直肠癌细胞增殖。此外,他们还表明,根据Sg细菌的生长阶段,该组织会推动结直肠癌细胞增殖,而且只有在细菌和癌细胞直接接触的情况下。

科学家们还研究了来自Sg的细菌分泌物或其他代谢物是否会导致癌细胞扩散,但他们发现,这些细菌本身并不足以促进癌细胞的生长。

此外,研究人员还研究了Sg对一种蛋白质的影响,该蛋白在结肠直肠癌的发展中起着至关重要的作用。正如作者所解释的那样,“在信号传导通路上的wnt/beta链调控细胞的命运和增殖,是结肠肿瘤发生的关键途径。”

因此,研究人员检查了β-连环蛋白对响应性和无反应性细胞的影响。

试验结果表明,当β-连环蛋白被抑制时,Sg不能驱动癌细胞的增殖。 这向研究人员建议,Sg使用β-连环蛋白信号通路来驱动结肠直肠癌细胞增殖。

此外,库玛尔和他的团队将研究小组注入到老鼠体内,这些老鼠被改造成结肠直肠癌,并与被注射不同细菌的对照组相比,监测它们的肿瘤生长情况。

接受研究的结肠直肠癌小鼠比对照组小鼠产生更多的肿瘤。这些小鼠也产生更多的β-连环蛋白,这表明癌症的严重程度增加。

最后,科学家们还对100多名结肠直肠癌患者的健康组织和肿瘤组织进行了检查。他们发现大约74%的肿瘤组织感染了Sg。

到目前为止,人们一直怀疑有结直肠癌的人可能有潜在的Sg感染,但是在这些病人中有多普遍没有充分的调查。研究者们得出这样的结论:

“研究结果表明,Sg积极促进结肠癌细胞增殖和肿瘤生长,表明它并不是一个无辜的“细菌”。这些结果代表了理解Sg和CRC直肠癌之间关系的重要一步。”

最后,库马尔和他的同事们希望,在未来的研究中,他们能够更好地理解驱动肿瘤形成的机制,这将有助于科学家改善“癌症诊断预防和治疗”。

原始出处:

Ritesh Kumar, Jennifer L. Herold, Deborah Schady, et al. Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development. PLOS Pathogens, 2017.

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    2017-08-23 flysky120

    链球菌彻底治疗了

    0

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    2017-08-22 Julie W

    最近的一项研究发现.一种细菌能促进结肠直肠癌的生长.而这是导致癌症死亡的第二大原因.

    0

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    2017-08-22 飛歌

    学习了很有用不错

    0

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    2017-08-22 luominglian113

    学习了.谢谢分享

    0

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    2017-08-21 thlabcde

    好东西学习了!

    0

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    2017-08-21 清风拂面

    谢谢分享.学习了

    0

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