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Circulation：调控动脉粥样硬化中的炎症和纤维增生性的新机制

2017-05-16 MedSci MedSci原创

动脉粥样硬化炎症
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动脉粥样硬化斑块形成是由血管壁的慢性炎症和纤维增生性重塑引起的。以前有研究证实，人和小鼠的动脉粥样硬化斑块都显示出EphA2的表达升高。EphA2是参与细胞-细胞相互作用和肿瘤发生的指导分子。近期，一项发表在杂志KIdney Int上的研究通过在动脉粥样硬化（Apoe-/-）的小鼠模型中敲除EphA2并通过评估多种血管细胞培养模型中的EphA2功能来评估EphA2在动脉粥样硬化中的作用。喂养8-1

动脉粥样硬化斑块形成是由血管壁的慢性炎症和纤维增生性重塑引起的。以前有研究证实，人和小鼠的动脉粥样硬化斑块都显示出EphA2的表达升高。EphA2是参与细胞-细胞相互作用和肿瘤发生的指导分子。


近期，一项发表在杂志Circulation上的研究通过在动脉粥样硬化（Apoe-/-）的小鼠模型中敲除EphA2并通过评估多种血管细胞培养模型中的EphA2功能来评估EphA2在动脉粥样硬化中的作用。喂养8-16周后，研究者们评估了西方饮食、雄性和雌性小鼠在大血管中的动脉粥样硬化负荷，并分析了血浆脂质水平。

此项研究结果显示：尽管与Apoe-/-对照相比，EphA2-/-Apoe- /-敲除小鼠的体重增加和血浆脂质水平增加，但是，动脉粥样硬化斑块形成减少，其特征在于促炎症基因表达和斑块巨噬细胞含量的降低。虽然斑块巨噬细胞表达EphA2，但是EphA2缺失不影响巨噬细胞表型，炎症反应和脂质摄取。骨髓嵌合体表明造血EphA2缺失不影响斑块形成。

相比之下，内皮EphA2敲低显着降低流动下的单核细胞粘连。此外，EphA2-/-Apoe-/-小鼠显示出来进展到晚期动脉粥样硬化斑块的减少以及平滑肌和胶原含量减少。与这种表型一致的是，EphA2在平滑肌转化为合成表型后显示出增强的表达，并且EphA2消耗减少动脉粥样硬化斑块和培养的血管平滑肌细胞中的平滑肌增殖，促有丝分裂信号和细胞外基质沉积。

此项研究表明：EphA2在动脉粥样硬化中具有新的作用，可以调节斑块炎症和进展为晚期动脉粥样硬化病变。细胞培养研究表明内皮EphA2通过促进单核细胞粘附而促进动脉粥样硬化性炎症，而平滑肌EphA2表达可通过调节平滑肌增殖和细胞外基质沉积来调节进展为晚期的动脉粥样硬化。

原始出处：
Finney AC, Funk SD, et al. EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis. Circulation. 2017 May 9. pii: CIRCULATIONAHA.116.026644. doi: 10.1161/CIRCULATIONAHA.116.026644.

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    2017-06-08 huangshifeng

    #粥样硬化#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1944455, encodeId=771b194445575, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Thu Jun 08 23:26:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757293, encodeId=d8871e57293e9, content=<a href='/topic/show?id=2f354231613' target=_blank style='color:#2F92EE;'>#增生性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42316, encryptionId=2f354231613, topicName=增生性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f7c37300907, createdName=ms7514935887898259, createdTime=Wed Jun 14 23:26:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199463, encodeId=286e1994635e, content=学习了，。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Thu May 18 06:49:38 CST 2017, time=2017-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198965, encodeId=7c8619896538, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed May 17 00:46:46 CST 2017, time=2017-05-17, status=1, ipAttribution=)]
    2017-06-14 ms7514935887898259

    #增生性#

    0

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    2017-05-18 135****7952平儿

    学习了，。。。。。

    0

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    2017-05-17 lou.minghong

    学习了

    0

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