Baidu
map

JCLA:血清尿酸可作为白塞病患者升主动脉扩张风险和严重程度增加的独立标志物

2019-06-01 不详 网络

本研究旨在探讨白塞病(BD)患者血清尿酸(SUA)与升主动脉扩张(AAD)风险及扩张直径的关系。 研究人员将17例合并AAD的BD患者和20例未合并AAD的BD患者纳入研究,并分别分为AAD组和对照组。采用二维多普勒超声心动图检测升主动脉扩张,AAD定义为升主动脉直径≥3.8 cm,小于4.4 cm。采用定量免疫分析法检测SUA。 研究发现,升主动脉扩张患者中男性比例较高(P = 0.

本研究旨在探讨白塞病(BD)患者血清尿酸(SUA)与升主动脉扩张(AAD)风险及扩张直径的关系。

研究人员将17例合并AADBD患者和20例未合并AADBD患者纳入研究,并分别分为AAD组和对照组。采用二维多普勒超声心动图检测升主动脉扩张,AAD定义为升主动脉直径≥3.8 cm,小于4.4 cm。采用定量免疫分析法检测SUA

研究发现,升主动脉扩张患者中男性比例较高(P = 0.003)高血压发生率较高(P = 0.036),升主动脉直径增大(P < 0.001)。与对照组相比,AAD患者的SUA升高(P = 0.002),接受者操作特性曲线显示,SUA对曲线下面积(AUC)0.821 (95% CI 0.6750.966)BD患者AAD风险具有较高的预测价值。Pearson的分析还揭示,在BD患者中,SUA与升主动脉直径呈正相关。但AAD患者与对照组CRP (P = 0.219)ESR (P = 0.320)无差异,总BD患者CRP (R = - 0.150, P = 0.377)ESR (R = 0.067, P = 0.692)与升主动脉直径无相关性。进一步的多因素logistic回归表明SUA是预测BD患者AAD风险的独立因素(P = 0.031)

研究表明,血清尿酸可作为BD患者AAD风险和严重程度增加的独立标志物。

原始出处:

Jianfei Cai , Yinjia Zhang ,Serum uric acid could be served as an independent marker for increased risk and severity of ascending aortic dilatation in Behçet's disease patients

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1841392, encodeId=eed9184139237, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon Feb 17 19:42:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684795, encodeId=67f21684e95d1, content=<a href='/topic/show?id=794754e74f4' target=_blank style='color:#2F92EE;'>#扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54774, encryptionId=794754e74f4, topicName=扩张)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=699d28086811, createdName=lsj637, createdTime=Sun May 17 06:42:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415520, encodeId=c6b7141552065, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466368, encodeId=ec6c146636863, content=<a href='/topic/show?id=6eda8939206' target=_blank style='color:#2F92EE;'>#血清尿酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89392, encryptionId=6eda8939206, topicName=血清尿酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99066802687, createdName=feifers, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580065, encodeId=f6aa1580065a0, content=<a href='/topic/show?id=d6872316e0a' target=_blank style='color:#2F92EE;'>#主动脉扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23167, encryptionId=d6872316e0a, topicName=主动脉扩张)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2a616575742, createdName=ms1065684921169360, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1841392, encodeId=eed9184139237, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon Feb 17 19:42:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684795, encodeId=67f21684e95d1, content=<a href='/topic/show?id=794754e74f4' target=_blank style='color:#2F92EE;'>#扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54774, encryptionId=794754e74f4, topicName=扩张)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=699d28086811, createdName=lsj637, createdTime=Sun May 17 06:42:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415520, encodeId=c6b7141552065, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466368, encodeId=ec6c146636863, content=<a href='/topic/show?id=6eda8939206' target=_blank style='color:#2F92EE;'>#血清尿酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89392, encryptionId=6eda8939206, topicName=血清尿酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99066802687, createdName=feifers, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580065, encodeId=f6aa1580065a0, content=<a href='/topic/show?id=d6872316e0a' target=_blank style='color:#2F92EE;'>#主动脉扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23167, encryptionId=d6872316e0a, topicName=主动脉扩张)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2a616575742, createdName=ms1065684921169360, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=)]
    2020-05-17 lsj637
  3. [GetPortalCommentsPageByObjectIdResponse(id=1841392, encodeId=eed9184139237, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon Feb 17 19:42:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684795, encodeId=67f21684e95d1, content=<a href='/topic/show?id=794754e74f4' target=_blank style='color:#2F92EE;'>#扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54774, encryptionId=794754e74f4, topicName=扩张)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=699d28086811, createdName=lsj637, createdTime=Sun May 17 06:42:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415520, encodeId=c6b7141552065, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466368, encodeId=ec6c146636863, content=<a href='/topic/show?id=6eda8939206' target=_blank style='color:#2F92EE;'>#血清尿酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89392, encryptionId=6eda8939206, topicName=血清尿酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99066802687, createdName=feifers, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580065, encodeId=f6aa1580065a0, content=<a href='/topic/show?id=d6872316e0a' target=_blank style='color:#2F92EE;'>#主动脉扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23167, encryptionId=d6872316e0a, topicName=主动脉扩张)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2a616575742, createdName=ms1065684921169360, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1841392, encodeId=eed9184139237, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon Feb 17 19:42:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684795, encodeId=67f21684e95d1, content=<a href='/topic/show?id=794754e74f4' target=_blank style='color:#2F92EE;'>#扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54774, encryptionId=794754e74f4, topicName=扩张)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=699d28086811, createdName=lsj637, createdTime=Sun May 17 06:42:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415520, encodeId=c6b7141552065, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466368, encodeId=ec6c146636863, content=<a href='/topic/show?id=6eda8939206' target=_blank style='color:#2F92EE;'>#血清尿酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89392, encryptionId=6eda8939206, topicName=血清尿酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99066802687, createdName=feifers, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580065, encodeId=f6aa1580065a0, content=<a href='/topic/show?id=d6872316e0a' target=_blank style='color:#2F92EE;'>#主动脉扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23167, encryptionId=d6872316e0a, topicName=主动脉扩张)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2a616575742, createdName=ms1065684921169360, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1841392, encodeId=eed9184139237, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Mon Feb 17 19:42:00 CST 2020, time=2020-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684795, encodeId=67f21684e95d1, content=<a href='/topic/show?id=794754e74f4' target=_blank style='color:#2F92EE;'>#扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54774, encryptionId=794754e74f4, topicName=扩张)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=699d28086811, createdName=lsj637, createdTime=Sun May 17 06:42:00 CST 2020, time=2020-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415520, encodeId=c6b7141552065, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466368, encodeId=ec6c146636863, content=<a href='/topic/show?id=6eda8939206' target=_blank style='color:#2F92EE;'>#血清尿酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89392, encryptionId=6eda8939206, topicName=血清尿酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99066802687, createdName=feifers, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580065, encodeId=f6aa1580065a0, content=<a href='/topic/show?id=d6872316e0a' target=_blank style='color:#2F92EE;'>#主动脉扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23167, encryptionId=d6872316e0a, topicName=主动脉扩张)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2a616575742, createdName=ms1065684921169360, createdTime=Mon Jun 03 06:42:00 CST 2019, time=2019-06-03, status=1, ipAttribution=)]

相关资讯

KIDNEY INT:血清尿酸浓度与1型糖尿病肾病没有因果联系!

因此,该研究结果表明,血清尿酸浓度与糖尿病肾病不具有因果关系,但其是肾脏损伤的下游标志物。

Hypertension:血清尿酸会通过影响内皮功能障碍导致高血压吗?

在这项随机,双盲,安慰剂对照试验中,降低尿酸水平并不会影响没有高血压的超重或肥胖患者的血管内皮功能。这些数据并不支持这一假设,即尿酸与内皮功能障碍存在因果关系,并且作为高血压发生的可能机制。

J Hypertens:血清尿酸和抗高血压治疗

由此可见,在ELSA研究中,SUA水平不影响对抗高血压治疗的反应性。

J Hypertens:血清尿酸对日本在职男性高血压发生的影响!

由此可见,血清尿酸水平与未来高血压发病率相关,在年轻男性、无糖尿病者和正常高密度脂蛋白胆固醇水平的日本男性在职人群中观察到了这种关联。

Sci Rep:血清尿酸与勃起功能异常有关!

血清尿酸(UA)在勃起功能异常(ED)的病理生理学发展中的角色是具有争议的。最近,有研究人员筛选了与ED相关的因子,并探究了血清UA与ED的关系。2014年到2015年中,在关于东亚代谢疾病和风险因素流行的研究中,研究人员从横断式调查法中获得了相关数据,并利用勃起功能异常国际指数-5调查问卷评估了ED的情况。研究人员从三个普通的群体中分别获得了有关数据。研究总共包括了1365名男性,平均年龄为55

SCI REP:肌萎缩侧索硬化症患者血清尿酸水平分析!

总之,血清尿酸水平与ALS患者的死亡风险呈负相关。需要高质量的随机对照试验来阐明尿酸对ALS的作用。

Baidu
map
Baidu
map
Baidu
map