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Diabetologia:前驱糖尿病个体的异常肠道微生物群

2018-05-04 MedSci MedSci原创

近日,国际杂志 《Diabetologia》上在线发表一项关于前驱糖尿病个体的异常肠道微生物群的研究。 2型糖尿病患者会表现出肠道微生物异常。然而,最近的研究表明,二甲双胍有改变肠道微生物群的组成和功能的潜力,从而干扰与糖尿病有关的微生物标记。研究人员测试了特定的肠道微生物群特征是否与前驱糖尿病(定义为空腹血糖6.1-7.0mmol/l或HbA 1c 42-48mmol/mol [6.0-6

近日,国际杂志 《Diabetologia》上在线发表一项关于前驱糖尿病个体的异常肠道微生物群的研究。 2型糖尿病患者会表现出肠道微生物异常。然而,最近的研究表明,二甲双胍有改变肠道微生物群的组成和功能的潜力,从而干扰与糖尿病有关的微生物标记。研究人员测试了特定的肠道微生物群特征是否与前驱糖尿病(定义为空腹血糖6.1-7.0mmol/l或HbA 1c 42-48mmol/mol [6.0-6.5%])以及一系列代谢不良健康的临床生物标志物相关。 在目前的病例对照研究中,研究人员分析了134名丹麦有前驱糖尿病,超重,胰岛素抵抗,血脂异常和低度炎症的成年人以及134名年龄和性别匹配的正常血糖调节的成人的肠道微生物群。 研究人员发现5个细菌属和36个操作分类单位(OTU)在糖尿病前期和葡萄糖调节正常的个体之间差异很大。在属水平,梭菌丰度下降(平均log 2倍数变化-0.64(SEM 0.23),p adj=0.0497),而Dorea,[ 瘤胃球菌 ],Sutterella和链球菌丰度均升高(平均log 2倍变化0.51(SEM 0.12),p adj=5×10 -4 ; 0.51(SEM

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    2018-09-04 智智灵药
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    2018-05-04 xiaogan8479

    非常好的文章.值得学习

    0

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