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Am J Transplant:肥大细胞有助于诱导眼粘膜同种异体免疫的发生

2018-09-09 MedSci MedSci原创

北京国家老年医学中心医院眼科的Li M近日在Am J Transplant发表了一篇文章,研究的目的是评估肥大细胞对同种异体眼表移植物排斥的主要影响。

北京国家老年医学中心医院眼科的Li M近日在Am J Transplant发表了一篇文章,研究的目的是评估肥大细胞对同种异体眼表移植物排斥的主要影响。

肥大细胞除了可以作为过敏性疾病中的效应细胞外,它们还涉及调节先天性和适应性免疫应答。肥大细胞具有相当大的功能可塑性,在主体和外部环境相互作用的粘膜表面非常丰富。

使用小鼠角膜移植模型,他们发现,肥大细胞可以促进同种异体的增敏效应。他们的数据显示,移植后肥大细胞的数量和细胞活性明显增加。研究者深入分析发现,抑制肥大细胞可以引起炎症细胞的浸润和APC在移植部位的成熟,其次可以减少引流淋巴组织中的同种异体化和Th1细胞的产生,第三能够减少同种免疫炎症细胞的移植物浸润,最后可以延长同种异体移植物的存活期。

因此,作者认为,他们的数据证明,肥大细胞在促进眼表面同种异体化方面具有重要的功能。

原文出处:

Li, M., et al., Mast cells contribute to the induction of ocular mucosal alloimmunity. Am J Transplant, 2018

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    2019-08-16 bsmagic9140
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    2018-12-30 guoyibin
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    2019-06-14 xuyu
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