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Am J Clin Nutr:黄酮类不能降低结直肠癌风险

2015-11-07 MedSci MedSci原创

黄酮类化合物体外抑制结肠癌细胞的生长。对息肉预防试验进行二次分析表明,更高的黄酮醇摄入,在统计学上显著降低晚期腺瘤复发的风险。先前的前瞻性研究关于结直肠癌评估,只有有限数量的黄酮类子类和摄入量范围,且产生不一致的结果。研究者进行了一项研究,探究习惯性摄入更高剂量黄酮类化合物(黄酮醇、黄酮、黄烷酮、黄烷醇和花青素)能否降低结直肠癌风险。该研究纳入了42,478名男性和76,364名女性,使用经验证的

黄酮类化合物体外抑制结肠癌细胞的生长。对息肉预防试验进行二次分析表明,更高的黄酮醇摄入,在统计学上显著降低晚期腺瘤复发的风险。先前的前瞻性研究关于结直肠癌评估,只有有限数量的黄酮类子类和摄入量范围,且产生不一致的结果。

研究者进行了一项研究,探究习惯性摄入更高剂量黄酮类化合物(黄酮醇、黄酮、黄烷酮、黄烷醇和花青素)能否降低结直肠癌风险。

该研究纳入了42,478名男性和76,364名女性,使用经验证的饮食-频率问卷调查每4年对其采集一次数据,并对类黄酮的食物成分数据库进行更新。

在长达26年的随访过程中,发生了2519例结直肠癌,男性1061人,女性1458人。黄酮类子类的摄入与结直肠癌风险无关。将子类摄入剂量由高到底划分5份,含量最高与最低组比较:黄酮醇 RR=1.04 (0.91, 1.18),黄酮 RR=1.01 (0.89, 1.15) ,黃烷酮 RR=0.96 (0.84, 1.10),黄烷醇 RR=1.07 (0.95, 1.21),花青素0.98 (0.81, 1.19)。子分析也没发现摄入黄酮类化合物与结直肠癌风险间关系。

研究结果并不支持习惯性摄入更多黄酮类化合物减少结直肠癌风险。


原始出处:

Nimptsch K, Zhang X,et al.Habitual intake of flavonoid subclasses and risk of colorectal cancer in 2 large prospective cohorts.Am J Clin Nutr. 2015 Nov 4.

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    2017-09-13 营养医师

    在中国结果肯定要优化了.然后说非常有作用

    0

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    2016-03-31 fengyi821
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    2016-03-18 sjq027
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  5. [GetPortalCommentsPageByObjectIdResponse(id=243636, encodeId=aa67243636f2, content=在中国结果肯定要优化了.然后说非常有作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e502075746, createdName=营养医师, createdTime=Wed Sep 13 21:23:03 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683561, encodeId=5df5168356169, content=<a href='/topic/show?id=3f17103210ed' target=_blank style='color:#2F92EE;'>#黄酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103210, encryptionId=3f17103210ed, topicName=黄酮)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=443c27982006, createdName=fengyi821, createdTime=Thu Mar 31 03:10:00 CST 2016, time=2016-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061489, encodeId=66e6206148934, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Fri Mar 18 04:10:00 CST 2016, time=2016-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705326, encodeId=52041e05326bd, content=<a href='/topic/show?id=7b9de87144b' target=_blank style='color:#2F92EE;'>#结直肠癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78714, encryptionId=7b9de87144b, topicName=结直肠癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c54a30977679, createdName=lfyang, createdTime=Thu May 12 17:10:00 CST 2016, time=2016-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50246, encodeId=b05b5024659, content=要学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Dec 29 15:48:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49425, encodeId=453a49425de, content=很值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Dec 27 17:39:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452772, encodeId=9d321452e7288, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Mon Nov 09 14:10:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42843, encodeId=55c14284373, content=许多保健品中招了, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:39:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-12-29 xyfg98

    要学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=243636, encodeId=aa67243636f2, content=在中国结果肯定要优化了.然后说非常有作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e502075746, createdName=营养医师, createdTime=Wed Sep 13 21:23:03 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683561, encodeId=5df5168356169, content=<a href='/topic/show?id=3f17103210ed' target=_blank style='color:#2F92EE;'>#黄酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103210, encryptionId=3f17103210ed, topicName=黄酮)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=443c27982006, createdName=fengyi821, createdTime=Thu Mar 31 03:10:00 CST 2016, time=2016-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061489, encodeId=66e6206148934, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Fri Mar 18 04:10:00 CST 2016, time=2016-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705326, encodeId=52041e05326bd, content=<a href='/topic/show?id=7b9de87144b' target=_blank style='color:#2F92EE;'>#结直肠癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78714, encryptionId=7b9de87144b, topicName=结直肠癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c54a30977679, createdName=lfyang, createdTime=Thu May 12 17:10:00 CST 2016, time=2016-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50246, encodeId=b05b5024659, content=要学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Dec 29 15:48:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49425, encodeId=453a49425de, content=很值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Dec 27 17:39:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452772, encodeId=9d321452e7288, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Mon Nov 09 14:10:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42843, encodeId=55c14284373, content=许多保健品中招了, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:39:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-12-27 忠诚向上

    很值得学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=243636, encodeId=aa67243636f2, content=在中国结果肯定要优化了.然后说非常有作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e502075746, createdName=营养医师, createdTime=Wed Sep 13 21:23:03 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683561, encodeId=5df5168356169, content=<a href='/topic/show?id=3f17103210ed' target=_blank style='color:#2F92EE;'>#黄酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103210, encryptionId=3f17103210ed, topicName=黄酮)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=443c27982006, createdName=fengyi821, createdTime=Thu Mar 31 03:10:00 CST 2016, time=2016-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061489, encodeId=66e6206148934, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Fri Mar 18 04:10:00 CST 2016, time=2016-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705326, encodeId=52041e05326bd, content=<a href='/topic/show?id=7b9de87144b' target=_blank style='color:#2F92EE;'>#结直肠癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78714, encryptionId=7b9de87144b, topicName=结直肠癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c54a30977679, createdName=lfyang, createdTime=Thu May 12 17:10:00 CST 2016, time=2016-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50246, encodeId=b05b5024659, content=要学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Dec 29 15:48:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49425, encodeId=453a49425de, content=很值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Dec 27 17:39:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452772, encodeId=9d321452e7288, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Mon Nov 09 14:10:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42843, encodeId=55c14284373, content=许多保健品中招了, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:39:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=243636, encodeId=aa67243636f2, content=在中国结果肯定要优化了.然后说非常有作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e502075746, createdName=营养医师, createdTime=Wed Sep 13 21:23:03 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683561, encodeId=5df5168356169, content=<a href='/topic/show?id=3f17103210ed' target=_blank style='color:#2F92EE;'>#黄酮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103210, encryptionId=3f17103210ed, topicName=黄酮)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=443c27982006, createdName=fengyi821, createdTime=Thu Mar 31 03:10:00 CST 2016, time=2016-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061489, encodeId=66e6206148934, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Fri Mar 18 04:10:00 CST 2016, time=2016-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705326, encodeId=52041e05326bd, content=<a href='/topic/show?id=7b9de87144b' target=_blank style='color:#2F92EE;'>#结直肠癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78714, encryptionId=7b9de87144b, topicName=结直肠癌风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c54a30977679, createdName=lfyang, createdTime=Thu May 12 17:10:00 CST 2016, time=2016-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50246, encodeId=b05b5024659, content=要学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Dec 29 15:48:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49425, encodeId=453a49425de, content=很值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Dec 27 17:39:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452772, encodeId=9d321452e7288, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Mon Nov 09 14:10:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42843, encodeId=55c14284373, content=许多保健品中招了, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Sun Nov 08 14:39:00 CST 2015, time=2015-11-08, status=1, ipAttribution=)]
    2015-11-08 medcardio

    许多保健品中招了

    0

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