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NEJM:内脏利什曼病-病例报道

2019-01-24 xing.T MedSci原创

婴儿利什曼原虫病由白蛉传播,是意大利和地中海地区所特有的病种。患者开始接受脂质体两性霉素B治疗。在1个月后的随访中,发热、腹痛和疲劳已经消退,体格检查显示脾肿大消退。

患者为一名49岁的健康男子,因发烧、腹痛、疲劳5个月以及无意识的体重减轻15kg而到急诊就诊。

体格检查显示肝脏和脾脏肿大,实验室检查显示白细胞计数为每立方毫米2040个(参考范围为4000-10000),血红蛋白水平为每分升9.2克(参考范围为14.0-18.0),血小板计数为每立方毫米50000个(参考范围为140000-400000)。血培养以及人类免疫缺陷病毒、乙型肝炎病毒、丙型肝炎病毒、巨细胞病毒和爱泼斯坦-巴尔病毒的检测均为阴性。



腹部的计算机断层扫描证实存在肝脏肿大和脾脏明显增大(如图A所示)。对骨髓抽吸物的检查显示无鞭毛体,每个都具有细胞核(如图B蓝色箭头所示)和动基体(如图B红色箭头所示)。这是利什曼病的典型表现,并且骨髓抽吸物的聚合酶链反应检查证实了诊断

婴儿利什曼原虫病由白蛉传播,是意大利和地中海地区所特有的病种。患者开始接受脂质体两性霉素B治疗。在1个月后的随访中,发热、腹痛和疲劳已经消退,体格检查显示脾肿大消退。

原始出处:

Giuseppe G. Loscocco,et al.Visceral Leishmaniasis.N Engl J Med 2019;https://www.nejm.org/doi/full/10.1056/NEJMicm1803648

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1951236, encodeId=60db195123629, content=<a href='/topic/show?id=4f5c322640f' target=_blank style='color:#2F92EE;'>#利什曼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32264, encryptionId=4f5c322640f, topicName=利什曼病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Fri Oct 18 15:05:00 CST 2019, time=2019-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359250, encodeId=a252359250e8, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Sat Jan 26 08:08:36 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359099, encodeId=2115359099f5, content=!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=880b2180676, createdName=傲然乘凉, createdTime=Thu Jan 24 09:57:47 CST 2019, time=2019-01-24, status=1, ipAttribution=)]
    2019-01-26 一天没事干

    很好的学习机会

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1951236, encodeId=60db195123629, content=<a href='/topic/show?id=4f5c322640f' target=_blank style='color:#2F92EE;'>#利什曼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32264, encryptionId=4f5c322640f, topicName=利什曼病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Fri Oct 18 15:05:00 CST 2019, time=2019-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359250, encodeId=a252359250e8, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Sat Jan 26 08:08:36 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359099, encodeId=2115359099f5, content=!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=880b2180676, createdName=傲然乘凉, createdTime=Thu Jan 24 09:57:47 CST 2019, time=2019-01-24, status=1, ipAttribution=)]
    2019-01-24 傲然乘凉

    !!!

    0

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