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房静远：胃肠癌发生与预防的相关信号通路与表观遗传修饰

2015-05-06 佚名 生物谷

胃肠癌信号通路静观遗传
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在2014肿瘤转化医学研讨会上，来自上海交通大学医学院附属仁济医院消化科主任房静远教授介绍了胃肠癌发生与预防的相关信号通路与表观遗传修饰。 房教授是上海市消化疾病研究所长、上海交通大学医学院附属仁济医院消化科主任、主要从事胃肠癌的临床研究工作。会议上，房教授分享了在胃肠癌发生机制方面的研究进展。 胃肠癌相关基因受天然反义转录本等表观遗传修饰方式调控： ① ADAMTS9是甲基化敏感基因，参

在2014肿瘤转化医学研讨会上，来自上海交通大学医学院附属仁济医院消化科主任房静远教授介绍了胃肠癌发生与预防的相关信号通路与表观遗传修饰。

房教授是上海市消化疾病研究所长、上海交通大学医学院附属仁济医院消化科主任、主要从事胃肠癌的临床研究工作。会议上，房教授分享了在胃肠癌发生机制方面的研究进展。

胃肠癌相关基因受天然反义转录本等表观遗传修饰方式调控： ① ADAMTS9是甲基化敏感基因，参与胃癌发生，且是胃癌独立的预后指标。②低氧诱导因子-1α (HIF-1α) 诱导的组蛋白去甲基化酶JMJD2B促进大肠癌细胞恶性表型转化。 ③miRNA 345的甲基化参与CRC的发生。④非编码RNA之一，天然反义转录本在胃癌发生中起重要作用。

高通量筛选发现促癌基因DHPS及其天然反义转录本WDR83在胃癌组织中表达上调，其两者间存在着双向调控作用。

胃肠癌发生发展中与增殖相关信号通路异常，后者亦受表观遗传修饰调控： ① JAK/STAT信号通路的活化促进胃肠癌的发生发展。STAT3在CRC中异常激活。敲除STAT3可上调CRC细胞E-cadherin而下调 N-cadherin和 vimentin的表达。STAT3 与 COX-2的相互作用，参与 H.pylori 致胃癌的过程。②Rho GTP酶通路在CRC发生中起重要作用。③运输蛋白微粒复合体（TRAPPC4）的LDC结构域在高尔基体与EKR2结合而参与ERK-MAPK通路活化；体内外实验示其影响胃癌生物学行为。④ CRC细胞中DNA甲基化涉及调控SHP1的表达。

表观遗传修饰和检测影响其调控的物质可早期预警大肠肿瘤： ①大于50岁年龄组低血浆叶酸者易发生CRA。②低膳食纤维、粪便中短链脂肪酸含量降低和相应的产丁酸盐菌群减少可能参与CRA的发生。

调控表观遗传修饰或信号通路，可预防大肠肿瘤发生： ①动物体内试验证明，应用维持DNA甲基化的叶酸制剂或抑制细胞增殖相关通路可预防小鼠CRC的发生，且首次证明叶酸的疗效与干预时机有关。 ②前瞻性随机对照多中心临床干预试验证明叶酸预防散发性CRA的初发。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2075639, encodeId=b3ae20e563911, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Mon Aug 31 17:03:00 CST 2015, time=2015-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539584, encodeId=2787153958438, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Fri May 08 00:03:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569265, encodeId=dd571569265c3, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Fri May 08 00:03:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22871, encodeId=ccda228e166, content=非常认可, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=acount, createdTime=Thu May 07 18:40:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22737, encodeId=ade022e37e9, content=找到了 视频http://xy.bioon.com/course_video/fang-jing-yuan-wei-chang-ai-fei-sheng-yu-yu332568.html, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6821618141, createdName=yu16a216, createdTime=Wed May 06 13:21:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22736, encodeId=604022e3663, content=实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Wed May 06 13:19:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22717, encodeId=4eb322e17aa, content=有视频可以看吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6821618141, createdName=yu16a216, createdTime=Wed May 06 09:55:00 CST 2015, time=2015-05-06, status=1, ipAttribution=)]
    2015-08-31 zhwj

    #表观遗传修饰#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2075639, encodeId=b3ae20e563911, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Mon Aug 31 17:03:00 CST 2015, time=2015-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539584, encodeId=2787153958438, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Fri May 08 00:03:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569265, encodeId=dd571569265c3, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Fri May 08 00:03:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22871, encodeId=ccda228e166, content=非常认可, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=acount, createdTime=Thu May 07 18:40:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22737, encodeId=ade022e37e9, content=找到了 视频http://xy.bioon.com/course_video/fang-jing-yuan-wei-chang-ai-fei-sheng-yu-yu332568.html, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6821618141, createdName=yu16a216, createdTime=Wed May 06 13:21:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22736, encodeId=604022e3663, content=实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Wed May 06 13:19:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22717, encodeId=4eb322e17aa, content=有视频可以看吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6821618141, createdName=yu16a216, createdTime=Wed May 06 09:55:00 CST 2015, time=2015-05-06, status=1, ipAttribution=)]
    2015-05-08 wgx310

    #信号通路#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2075639, encodeId=b3ae20e563911, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Mon Aug 31 17:03:00 CST 2015, time=2015-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539584, encodeId=2787153958438, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Fri May 08 00:03:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569265, encodeId=dd571569265c3, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Fri May 08 00:03:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22871, encodeId=ccda228e166, content=非常认可, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=acount, createdTime=Thu May 07 18:40:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22737, encodeId=ade022e37e9, content=找到了 视频http://xy.bioon.com/course_video/fang-jing-yuan-wei-chang-ai-fei-sheng-yu-yu332568.html, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6821618141, createdName=yu16a216, createdTime=Wed May 06 13:21:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22736, encodeId=604022e3663, content=实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Wed May 06 13:19:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22717, encodeId=4eb322e17aa, content=有视频可以看吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6821618141, createdName=yu16a216, createdTime=Wed May 06 09:55:00 CST 2015, time=2015-05-06, status=1, ipAttribution=)]
    2015-05-08 zhangyxzsh

    #修饰#

    0

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    2015-05-07 acount

    非常认可

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2075639, encodeId=b3ae20e563911, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Mon Aug 31 17:03:00 CST 2015, time=2015-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539584, encodeId=2787153958438, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Fri May 08 00:03:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569265, encodeId=dd571569265c3, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Fri May 08 00:03:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22871, encodeId=ccda228e166, content=非常认可, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=acount, createdTime=Thu May 07 18:40:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22737, encodeId=ade022e37e9, content=找到了 视频http://xy.bioon.com/course_video/fang-jing-yuan-wei-chang-ai-fei-sheng-yu-yu332568.html, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6821618141, createdName=yu16a216, createdTime=Wed May 06 13:21:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22736, encodeId=604022e3663, content=实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Wed May 06 13:19:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22717, encodeId=4eb322e17aa, content=有视频可以看吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6821618141, createdName=yu16a216, createdTime=Wed May 06 09:55:00 CST 2015, time=2015-05-06, status=1, ipAttribution=)]
    2015-05-06 yu16a216

    找到了 视频http://xy.bioon.com/course_video/fang-jing-yuan-wei-chang-ai-fei-sheng-yu-yu332568.html

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2075639, encodeId=b3ae20e563911, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Mon Aug 31 17:03:00 CST 2015, time=2015-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539584, encodeId=2787153958438, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Fri May 08 00:03:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569265, encodeId=dd571569265c3, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Fri May 08 00:03:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22871, encodeId=ccda228e166, content=非常认可, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=acount, createdTime=Thu May 07 18:40:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22737, encodeId=ade022e37e9, content=找到了 视频http://xy.bioon.com/course_video/fang-jing-yuan-wei-chang-ai-fei-sheng-yu-yu332568.html, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6821618141, createdName=yu16a216, createdTime=Wed May 06 13:21:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22736, encodeId=604022e3663, content=实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Wed May 06 13:19:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22717, encodeId=4eb322e17aa, content=有视频可以看吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6821618141, createdName=yu16a216, createdTime=Wed May 06 09:55:00 CST 2015, time=2015-05-06, status=1, ipAttribution=)]
    2015-05-06 zhouanxiu

    实用

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2075639, encodeId=b3ae20e563911, content=<a href='/topic/show?id=afce902528d' target=_blank style='color:#2F92EE;'>#表观遗传修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90252, encryptionId=afce902528d, topicName=表观遗传修饰)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d7367, createdName=zhwj, createdTime=Mon Aug 31 17:03:00 CST 2015, time=2015-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539584, encodeId=2787153958438, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Fri May 08 00:03:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569265, encodeId=dd571569265c3, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Fri May 08 00:03:00 CST 2015, time=2015-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22871, encodeId=ccda228e166, content=非常认可, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=acount, createdTime=Thu May 07 18:40:00 CST 2015, time=2015-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22737, encodeId=ade022e37e9, content=找到了 视频http://xy.bioon.com/course_video/fang-jing-yuan-wei-chang-ai-fei-sheng-yu-yu332568.html, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6821618141, createdName=yu16a216, createdTime=Wed May 06 13:21:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22736, encodeId=604022e3663, content=实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Wed May 06 13:19:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=22717, encodeId=4eb322e17aa, content=有视频可以看吗？, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6821618141, createdName=yu16a216, createdTime=Wed May 06 09:55:00 CST 2015, time=2015-05-06, status=1, ipAttribution=)]
    2015-05-06 yu16a216

    有视频可以看吗？

    0

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