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Eur Respir J:吸入糖皮质激素与COPD患者肺癌风险

2019-06-08 xing.T 网络

由此可见,这项基于人群的研究表明,ICS的使用降低了COPD患者肺癌风险。

吸入皮质类固醇(ICS)通常用于慢性阻塞性肺病(COPD)患者。它们对COPD患者死亡的主要原因-肺癌风险的影响仍然不确定。

近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员调查了1997年至2007年间来自加拿大不列颠哥伦比亚省的基于人群的相关行政数据被用于评估肺癌风险与COPD患者ICS使用之间的关联。COPD的定义基于在≥50岁的受试者中接受三种与COPD相关的处方药物治疗。研究人员使用几种时间依赖性方法(“永久”暴露、累积使用持续时间、累积剂量、加权累积使用持续时间和加权累积剂量)将暴露于ICS纳入多变量Cox回归模型。

该研究有39676名患者符合纳入标准。该队列的平均年龄±SD为70.7±11.1岁,53%为女性。随访期间有994例(2.5%)肺癌病例。在对照病例分析(时间依赖性“永久性”暴露)中,ICS暴露与肺癌风险降低30%相关(HR为0.70(95%CI为0.61-0.80))。与所有五种量化暴露方法相比,ICS暴露与肺癌诊断风险降低有关。

由此可见,这项基于人群的研究表明,ICS的使用降低了COPD患者肺癌风险。 

原始出处:

Adam J.N. Raymakers,et al.Inhaled corticosteroids and the risk of lung cancer in COPD: a population-based cohort study.Eur Respir J.2019.https://erj.ersjournals.com/content/53/6/1801257

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    2019-07-21 sjq027
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    2019-06-10 gous
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