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Diabetes Care:2型糖尿病患者发生阻塞性睡眠呼吸暂停的风险

2019-03-13 xing.T 网络

当将先前的证据一起考虑时,该研究表明2型糖尿病与OSA之间的关联是双向的。除已知的OSA预测因素外,糖尿病相关的足部疾病和胰岛素治疗被确定为2型糖尿病患者的危险因素。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究旨在比较了2型糖尿病患者阻塞性睡眠呼吸暂停(OSA)的发生率,并分析2型糖尿病患者OSA的危险因素。

研究人员进行了一项回顾性队列研究,以比较2型糖尿病和匹配年龄、性别和BMI的无2型糖尿病个体OSA发生率。研究人员排除了OSA患者。该研究队列来自于2005年1月1日至2017年12月31日期间英国初级保健数据库健康改善网络(THIN)。

在360250例暴露患者和1296489例未暴露患者队列中分别发现了3110例(0.88%)和5968例(0.46%)OSA病例。2型糖尿病患者OSA的调整发生率(aIRR)与未患者相比为1.48(95%CI为1.42-1.55; P<0.001)。在对2型糖尿病患者进行的多元回归分析中,OSA的显著预测因素包含与糖尿病相关的足部疾病(1.23[1.06-1.42]; P=0.005)、在过去60天内开出胰岛素处方(1.58[1.42-1.75]); P<0.001)、男性(2.27[2.09-2.46]; P<0.001)、超重(2.02[1.54-2.64]; P<0.001)或肥胖(8.29[6.42-10.69]; P<0.001)、心力衰竭(1.41[1.18-1.70]; P<0.001)、缺血性心脏病(1.22[1.11-1.34]; P<0.001)、心房颤动(1.23[1.04-1.46]; P=0.015)、高血压(1.32[1.23-1.43]; P<0.001)和抑郁症(1.75[1.61-1.91]; P<0.001)。

当将先前的证据一起考虑时,该研究表明2型糖尿病与OSA之间的关联是双向的。除已知的OSA预测因素外,糖尿病相关的足部疾病和胰岛素治疗被确定为2型糖尿病患者的危险因素。

原始出处:

Anuradhaa Subramanian, et al.Risk of Incident Obstructive Sleep Apnea Among Patients With Type 2 Diabetes.Diabetes Care.2019.https://doi.org/10.2337/dc18-2004

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    2019-03-14 misszhang

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心衰患者降糖有顾忌?指南喊你放心用二甲双胍啦!

临床上,2型糖尿病(T2DM)与慢性心衰是典型的“难兄难弟”。数据表明,10%~30%的T2DM患者合并心衰,而慢性心衰患者中T2DM的患病率也高达30%[1]。关于降糖药物对心衰的影响,近年来颇受关注。二甲双胍作为国内外指南一致推荐的T2DM一线首选用药,是否同样适用于心衰患者?让我们一起来看看最新的指南和证据。

Metabolism:GAD65抗体与2型糖尿病

由此可见,GAD65抗体阳性与成人2型糖尿病风险增加有关。

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