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J Clin Med：体重对艾多沙班治疗房颤患者临床结局的影响是什么样的？（ETNA-AF-Europe注册研究）

2021-07-10 “心关注”公众号 “心关注”公众号

房颤艾多沙班
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超重和肥胖已被确定为房颤发生的危险因素，但体重过轻对房颤的影响尚未得到充分探讨。解释肥胖与房颤之间联系的病理机制复杂，且暂未得到充分认识。目前认为，心外膜脂肪组织增厚、左心房扩大和舒张功能障碍与心房重

超重和肥胖已被确定为房颤发生的危险因素，但体重过轻对房颤的影响尚未得到充分探讨。解释肥胖与房颤之间联系的病理机制复杂，且暂未得到充分认识。目前认为，心外膜脂肪组织增厚、左心房扩大和舒张功能障碍与心房重塑有关，进而导致超重/肥胖者患房颤风险的增加。 非维生素K拮抗剂口服抗凝血药(NOACs)是房颤患者预防脑卒中的首选药物。NOACs的抗凝作用与其血药浓度有关，血药浓度又受机体分布体积的影响。因此，极端体重(如体重过轻和肥胖)可能会改变NOACs的暴露程度及作用效果，从而影响临床结果。 由于担心肥胖人群药物暴露降低和剂量不足的风险，2016年国际血栓和止血科学与标准化委员会(ISTH SSC)建议体重高于120 kg或BMI大于40 kg/m2的患者避免使用NOACs，因缺乏相关研究数据的支持，该建议中没有对低体重患者使用NOACs给予明确指导。 ETNA-AF-Europe注册研究此项亚组旨在分析体重≤60 kg 、>100 kg的常规护理患者与对照组（>60kg-≤80kg）的患者在接受口服艾多沙班治疗1年后的临床结果。此外，作为二次分析，该研究还评估了BMI<18.

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    2021-10-01 dlwang_26703139

    #注册研究#

    0

  2. 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    2022-02-21 feather89

    #PE#

    0

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time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031419, encodeId=8e6c1031419be, content=房颤，临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sat Jul 10 14:30:40 CST 2021, time=2021-07-10, status=1, ipAttribution=)]
    2022-04-20 mei531

    #临床结局#

    0

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topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Mon Jul 12 02:30:40 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611138, encodeId=144516111386a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jul 12 02:30:40 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614604, encodeId=588c1614604a1, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Mon Jul 12 02:30:40 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998601, encodeId=54cd998601fc, content=<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>体重会影像房颤治疗疗效, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f221859736, createdName=ms2658711348342440, createdTime=Sun Jul 11 21:10:24 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998332, encodeId=efef9983328a, content=又头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210616/0f0e195fe7b24d569a1f39751df92fe2/ae01b1208252480f9e001617ce565271.jpg, createdBy=91e25526337, createdName=土豆你个马铃薯, createdTime=Sun Jul 11 00:16:06 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998215, encodeId=7b7f9982155e, content=保持体重很有必要, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/0e992c9cbb7e4bfc82d642ba0e9fe718/6fa4c63468cc49febcc91dba2fb4201a.jpg, createdBy=fa625399541, createdName=DIfh, createdTime=Sat Jul 10 15:43:02 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031419, encodeId=8e6c1031419be, content=房颤，临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sat Jul 10 14:30:40 CST 2021, time=2021-07-10, status=1, ipAttribution=)]
    2021-07-12 zhyy93

    #注册#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1764779, encodeId=a1871e6477902, content=<a href='/topic/show?id=c73964968de' target=_blank style='color:#2F92EE;'>#注册研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64968, encryptionId=c73964968de, topicName=注册研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=510b37798730, createdName=dlwang_26703139, createdTime=Fri Oct 01 05:30:40 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729031, encodeId=55601e29031b1, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, 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style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Mon Jul 12 02:30:40 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998601, encodeId=54cd998601fc, content=<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>体重会影像房颤治疗疗效, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f221859736, createdName=ms2658711348342440, createdTime=Sun Jul 11 21:10:24 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998332, encodeId=efef9983328a, content=又头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210616/0f0e195fe7b24d569a1f39751df92fe2/ae01b1208252480f9e001617ce565271.jpg, createdBy=91e25526337, createdName=土豆你个马铃薯, createdTime=Sun Jul 11 00:16:06 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998215, encodeId=7b7f9982155e, content=保持体重很有必要, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/0e992c9cbb7e4bfc82d642ba0e9fe718/6fa4c63468cc49febcc91dba2fb4201a.jpg, createdBy=fa625399541, createdName=DIfh, createdTime=Sat Jul 10 15:43:02 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031419, encodeId=8e6c1031419be, content=房颤，临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sat Jul 10 14:30:40 CST 2021, time=2021-07-10, status=1, ipAttribution=)]
    2021-07-12 ms3994565386320060

    #Med#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1764779, encodeId=a1871e6477902, content=<a href='/topic/show?id=c73964968de' target=_blank style='color:#2F92EE;'>#注册研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64968, encryptionId=c73964968de, topicName=注册研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=510b37798730, createdName=dlwang_26703139, createdTime=Fri Oct 01 05:30:40 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729031, encodeId=55601e29031b1, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Feb 21 08:30:40 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843262, encodeId=19d4184326240, content=<a href='/topic/show?id=3d052296e4e' target=_blank style='color:#2F92EE;'>#临床结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22967, encryptionId=3d052296e4e, topicName=临床结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Wed Apr 20 07:30:40 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556912, encodeId=20811556912d1, content=<a href='/topic/show?id=e4016495635' target=_blank style='color:#2F92EE;'>#注册#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64956, encryptionId=e4016495635, topicName=注册)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c52c14833361, createdName=zhyy93, createdTime=Mon Jul 12 02:30:40 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611138, encodeId=144516111386a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jul 12 02:30:40 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614604, encodeId=588c1614604a1, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Mon Jul 12 02:30:40 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998601, encodeId=54cd998601fc, content=<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>体重会影像房颤治疗疗效, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f221859736, createdName=ms2658711348342440, createdTime=Sun Jul 11 21:10:24 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998332, encodeId=efef9983328a, content=又头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210616/0f0e195fe7b24d569a1f39751df92fe2/ae01b1208252480f9e001617ce565271.jpg, createdBy=91e25526337, createdName=土豆你个马铃薯, createdTime=Sun Jul 11 00:16:06 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998215, encodeId=7b7f9982155e, content=保持体重很有必要, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/0e992c9cbb7e4bfc82d642ba0e9fe718/6fa4c63468cc49febcc91dba2fb4201a.jpg, createdBy=fa625399541, createdName=DIfh, createdTime=Sat Jul 10 15:43:02 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031419, encodeId=8e6c1031419be, content=房颤，临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sat Jul 10 14:30:40 CST 2021, time=2021-07-10, status=1, ipAttribution=)]
    2021-07-12 hittouch

    #房颤患者#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1764779, encodeId=a1871e6477902, content=<a href='/topic/show?id=c73964968de' target=_blank style='color:#2F92EE;'>#注册研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64968, encryptionId=c73964968de, topicName=注册研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=510b37798730, createdName=dlwang_26703139, createdTime=Fri Oct 01 05:30:40 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1729031, encodeId=55601e29031b1, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, 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style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Mon Jul 12 02:30:40 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998601, encodeId=54cd998601fc, content=<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>体重会影像房颤治疗疗效, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f221859736, createdName=ms2658711348342440, createdTime=Sun Jul 11 21:10:24 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998332, encodeId=efef9983328a, content=又头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210616/0f0e195fe7b24d569a1f39751df92fe2/ae01b1208252480f9e001617ce565271.jpg, createdBy=91e25526337, createdName=土豆你个马铃薯, createdTime=Sun Jul 11 00:16:06 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998215, encodeId=7b7f9982155e, content=保持体重很有必要, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/0e992c9cbb7e4bfc82d642ba0e9fe718/6fa4c63468cc49febcc91dba2fb4201a.jpg, createdBy=fa625399541, createdName=DIfh, createdTime=Sat Jul 10 15:43:02 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031419, encodeId=8e6c1031419be, content=房颤，临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sat Jul 10 14:30:40 CST 2021, time=2021-07-10, status=1, ipAttribution=)]
    2021-07-11 ms2658711348342440

    #心血管#体重会影像房颤治疗疗效

    0

  8. 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time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031419, encodeId=8e6c1031419be, content=房颤，临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sat Jul 10 14:30:40 CST 2021, time=2021-07-10, status=1, ipAttribution=)]
    2021-07-11 土豆你个马铃薯

    又头疼

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998332, encodeId=efef9983328a, content=又头疼, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210616/0f0e195fe7b24d569a1f39751df92fe2/ae01b1208252480f9e001617ce565271.jpg, createdBy=91e25526337, createdName=土豆你个马铃薯, createdTime=Sun Jul 11 00:16:06 CST 2021, time=2021-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=998215, encodeId=7b7f9982155e, content=保持体重很有必要, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201107/0e992c9cbb7e4bfc82d642ba0e9fe718/6fa4c63468cc49febcc91dba2fb4201a.jpg, createdBy=fa625399541, createdName=DIfh, createdTime=Sat Jul 10 15:43:02 CST 2021, time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031419, encodeId=8e6c1031419be, content=房颤，临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sat Jul 10 14:30:40 CST 2021, time=2021-07-10, status=1, ipAttribution=)]
    2021-07-10 DIfh

    保持体重很有必要

    0

  10. 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time=2021-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031419, encodeId=8e6c1031419be, content=房颤，临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sat Jul 10 14:30:40 CST 2021, time=2021-07-10, status=1, ipAttribution=)]
    2021-07-10 心介

    房颤，临床上碰到很多哦

    0

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