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J Asthma Allergy:中国南方过敏性鼻炎和哮喘患者的花生过敏以及与花粉过敏的交叉反应分析

2021-11-24 AlexYang MedSci原创

调查了中国南方人群过敏性鼻炎和/或哮喘患者的花生致敏性和与花粉过敏原的交叉反应情况。

近年来,过敏性疾病的发病率一直在增加,给社会带来了巨大的经济负担。在西方和东方国家,食物过敏和呼吸道过敏性疾病的患病率均急剧上升。许多植物过敏原,如泛过敏原,可与植物来源的食物和花粉过敏原中的同源蛋白发生交叉反应,引起花粉食物过敏综合征,这是一种由免疫球蛋白E(IgE)介导的常见过敏性疾病。

花生是西方国家最常报道的引起严重过敏的过敏原之一。但在中国,由花生引起的严重过敏的报道却很少

近期,来自广州医科大学的研究人员在《J Asthma Allergy》杂志上发表文章,调查了中国南方人群过敏性鼻炎和/或哮喘患者的花生致敏性和与花粉过敏原的交叉反应情况

研究人员用ImmunoCAP系统检测了58名过敏患者对Ara h 1、Ara h 8、Juglans花粉、Platanus花粉、桦树花粉、Bet v 1、Bet v 4和交叉反应的碳水化合物决定因子(CCD)的总IgE(tIgE)和特异性IgE(sIgE)抗体。其中33人花生IgE阳性,25人阴性,并进一步分析了花生过敏原和花粉过敏原之间的关系。

结果发现,9.1%(3/33)的花生过敏患者对Ara h 8过敏,而21.2%(7/33)的患者对Ara h 1过敏。花生过敏组对CCD(69.7% vs 4.0%)、Juglans花粉(87.9% vs 12.0%)、Platanus花粉(90.9% vs 16.0%)和桦树花粉(60.6% vs 4.0%)的sIgE抗体阳性率明显高于花生耐受组(所有P<0.05)。Spearman相关显示,花生的IgE与CCD(rs=0.859)、Juglans花粉(rs=0.772)、桔梗花粉(rs=0.838)和桦树花粉(rs=0.816)的sIgE显著相关。

花生、法国梧桐、桦树和胡桃过敏原过敏的韦恩图

综上所述,在中国南方,大多数对花生过敏的患者也对多种花粉过敏原过敏。花生过敏与法国梧桐、胡桃和桦树花粉过敏高度相关,表明花生和花粉过敏原之间可能存在交叉反应。因此,临床医生在花生过敏诊断和治疗中应注意区分诊断

 

原始出处:

Wenting Luo, Shuwen Yang, Huimin Huang et al. Analysis of Peanut Allergen Components Sensitization and Cross Reaction with Pollen Allergen in Chinese Southerners with Allergic Rhinitis and/or Asthma. J Asthma Allergy. Oct 2021.

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    2022-05-11 skhzy
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    2021-11-25 膀胱癌
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