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Ann Surg：宿主防御肽在出血性休克中的保护作用

2017-03-23 MedSci MedSci原创

Pep19-4LFHSMOF
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出血性休克（HS）是严重受伤患者死亡的常见原因。目前，尚无具体的疗法以降低HS相关的多器官功能衰竭（MOF）。近期，一项发表在杂志Ann Surg上的研究旨在评估：（1）创伤和HS患者宿主防御/抗菌肽LL-37的水平；（2）合成宿主抗原肽以及Pep19-4LF对HS相关的MOF的作用。研究者们首先测量了入住城市重大创伤中心的47例创伤/ HS患者的LL-37水平。 随后使用雄性Wistar大鼠进行

出血性休克（HS）是严重受伤患者死亡的常见原因。目前，尚无具体的疗法以降低HS相关的多器官功能衰竭（MOF）。


近期，一项发表在杂志Ann Surg上的研究旨在评估：（1）创伤和HS患者宿主防御/抗菌肽LL-37的水平；（2）合成宿主抗原肽以及Pep19-4LF对HS相关的MOF的作用。

研究者们首先测量了入住城市重大创伤中心的47例创伤/ HS患者的LL-37水平。 随后使用雄性Wistar大鼠进行HS（90分钟，目标平均动脉压：27-32mmHg）或假手术出来。复苏后的大鼠用Pep19-4LF [66（n = 8）或333μg/ kg·h（n = 8）]或载体（n = 12）处理4小时。

此项研究结果显示：与健康者相比，创伤/ HS患者血浆LL-37高出12倍。相对于使用载体处理的HS大鼠，用Pep19-4LF（高剂量）治疗的HS大鼠在4小时复苏期结束时具有较高的平均动脉压（79±4 vs 54±5mmHg），较少的肾功能障碍、肝损伤和肺部炎症反应。 Pep19-4LF增强（肾/肝）蛋白激酶B和内皮一氧化氮合酶磷酸化。Pep19-4LF减弱了HS诱导的p65从细胞质向细胞核中的迁移，Ser的IκB激酶的磷酸化以及Ser的IκBα磷酸化，导致核因子κB的抑制和促炎因子的形成。 Pep19-4LF通过与这种损伤相关的分子模式结合，阻止了人类单核细胞中硫酸乙酰肝素引起的肿瘤坏死因子α的释放。

此项研究表明：创伤相关的HS导致LL-37的释放。宿主防御/抗菌肽Pep19-4LF的合成可以减轻与HS相关的器官损伤/功能障碍。

原始出处：
Yamada N, Martin LB, et al. Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock. Ann Surg. 2017 Mar 10. doi: 10.1097/SLA.0000000000002186. 

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    2018-01-07 12498710m20暂无昵称

    #出血性休克#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1687667, encodeId=5057168e66722, content=<a href='/topic/show?id=9703314568d' target=_blank style='color:#2F92EE;'>#出血性休克#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31456, encryptionId=9703314568d, topicName=出血性休克)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0e028409960, createdName=12498710m20暂无昵称, createdTime=Sun Jan 07 16:36:00 CST 2018, time=2018-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404667, encodeId=3879140466e06, content=<a href='/topic/show?id=1a4f4649925' target=_blank style='color:#2F92EE;'>#宿主#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46499, encryptionId=1a4f4649925, topicName=宿主)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/08904ED76550A0090DB220A7FB81D755/100, createdBy=78512492586, createdName=wincls, createdTime=Sat Mar 25 04:36:00 CST 2017, time=2017-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599045, encodeId=ccbd1599045dc, content=<a href='/topic/show?id=f14d2e187ac' target=_blank style='color:#2F92EE;'>#保护作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27187, encryptionId=f14d2e187ac, topicName=保护作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ee918684940, createdName=photoman, createdTime=Sat Mar 25 04:36:00 CST 2017, time=2017-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182190, encodeId=e74d182190ad, content=好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Thu Mar 23 14:19:46 CST 2017, time=2017-03-23, status=1, ipAttribution=)]
    2017-03-25 wincls

    #宿主#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1687667, encodeId=5057168e66722, content=<a href='/topic/show?id=9703314568d' target=_blank style='color:#2F92EE;'>#出血性休克#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31456, encryptionId=9703314568d, topicName=出血性休克)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0e028409960, createdName=12498710m20暂无昵称, createdTime=Sun Jan 07 16:36:00 CST 2018, time=2018-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404667, encodeId=3879140466e06, content=<a href='/topic/show?id=1a4f4649925' target=_blank style='color:#2F92EE;'>#宿主#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46499, encryptionId=1a4f4649925, topicName=宿主)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/08904ED76550A0090DB220A7FB81D755/100, createdBy=78512492586, createdName=wincls, createdTime=Sat Mar 25 04:36:00 CST 2017, time=2017-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599045, encodeId=ccbd1599045dc, content=<a href='/topic/show?id=f14d2e187ac' target=_blank style='color:#2F92EE;'>#保护作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27187, encryptionId=f14d2e187ac, topicName=保护作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ee918684940, createdName=photoman, createdTime=Sat Mar 25 04:36:00 CST 2017, time=2017-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182190, encodeId=e74d182190ad, content=好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Thu Mar 23 14:19:46 CST 2017, time=2017-03-23, status=1, ipAttribution=)]
    2017-03-25 photoman

    #保护作用#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1687667, encodeId=5057168e66722, content=<a href='/topic/show?id=9703314568d' target=_blank style='color:#2F92EE;'>#出血性休克#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31456, encryptionId=9703314568d, topicName=出血性休克)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0e028409960, createdName=12498710m20暂无昵称, createdTime=Sun Jan 07 16:36:00 CST 2018, time=2018-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404667, encodeId=3879140466e06, content=<a href='/topic/show?id=1a4f4649925' target=_blank style='color:#2F92EE;'>#宿主#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46499, encryptionId=1a4f4649925, topicName=宿主)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/08904ED76550A0090DB220A7FB81D755/100, createdBy=78512492586, createdName=wincls, createdTime=Sat Mar 25 04:36:00 CST 2017, time=2017-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599045, encodeId=ccbd1599045dc, content=<a href='/topic/show?id=f14d2e187ac' target=_blank style='color:#2F92EE;'>#保护作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27187, encryptionId=f14d2e187ac, topicName=保护作用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ee918684940, createdName=photoman, createdTime=Sat Mar 25 04:36:00 CST 2017, time=2017-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182190, encodeId=e74d182190ad, content=好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=118f1734484, createdName=1def5ef1m18(暂无匿称), createdTime=Thu Mar 23 14:19:46 CST 2017, time=2017-03-23, status=1, ipAttribution=)]
    2017-03-23 1def5ef1m18(暂无匿称)

    好！

    0

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