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Neurology:警惕!抑郁症很可能发展成为帕金森病

2015-05-28 佚名 生物谷

根据美国神经病学学会的医学杂志《神经学》上的一项发表在2015年5月20日的大型研究发现,抑郁症患者可能更容易患上帕金森症。 “我们用二十多年的时间观察到了抑郁症和帕金森病之间的联系,因此抑郁症可能是帕金森病的早期症状或疾病的一个危险因素。” Peter Nordstrm博士说,该项研究内容发表在瑞典于默奥大学期刊上。 研究人员还研究了同胞兄弟姐妹之间的关联,没有发现,一个孩子有抑郁症,其

根据美国神经病学学会的医学杂志《神经学》上的一项发表在2015年5月20日的大型研究发现,抑郁症患者可能更容易患上帕金森症。

“我们用二十多年的时间观察到了抑郁症和帕金森病之间的联系,因此抑郁症可能是帕金森病的早期症状或疾病的一个危险因素。” Peter Nordstrm博士说,该项研究内容发表在瑞典于默奥大学期刊上。

研究人员还研究了同胞兄弟姐妹之间的关联,没有发现,一个孩子有抑郁症,其他孩子会有帕金森病这样的联系。“这个发现为我们提供了更多的证据表明这两种疾病是相关联的,” Nordstrm说。“如果这两种疾病相互独立,但都是由早期相同的遗传或环境因素造成的,那么我们会看到这两种疾病会在同胞兄妹之间发生,但事实上这种情况没有发生。”

2005年底在这项研究中,研究人员开始研究年龄在50岁及50岁以上的所有瑞典公民。他们找出来在1987年到2012年间被诊断为患有抑郁症的140688人作为实验组。这些人与三个对照组进行配对观察,对照组中参与者的性别和出生年份与实验组相同且没有被诊断为抑郁症,一共有421718位参与者作为对照组。

之后对这项研究进行了长达26年的跟踪调查。在此期间,1485名抑郁症患者并发了帕金森病,约占1.1%,而有1775人未患抑郁症而患了帕金森病,约占0.4%。

研究开始后平均4.5年就有被诊断为帕金森病的病人。随时间的延长患帕金森氏症的可能性逐渐降低。与没有抑郁症的人相比,研究开始后的一年之内抑郁症患者有3.2倍的可能性患上帕金森病。在研究开始后的15到25年间,抑郁症患者约有50%的可能性患上帕金森症。

更严重的抑郁患者也更容易患帕金森病。相比因抑郁症住院只有一次的患者,因抑郁症住院五次以上的患者有40%的可能性患上帕金森症。与门诊治疗抑郁症的人相比,因抑郁症住院的患者有3.5倍的可能性患帕金森病。

当研究人员调整与抑郁症相关的其他条件时,抑郁症和帕金森病之间的关联并没有因此改变,比如创伤性脑损伤、中风、酒精和药物滥用等。

原始出处:

Helena Gustafsson, MD, Anna Nordström, PhD and Peter Nordström, PhD.Depression and subsequent risk of Parkinson disease.Neurology, May 20, 2015.doi: 10.1212/WNL.0000000000001684

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  1. [GetPortalCommentsPageByObjectIdResponse(id=269387, encodeId=7e2d26938e1f, content=我要收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170206/IMG589879E392F941842.jpg, createdBy=f4d469996, createdName=wangyunyb, createdTime=Thu Dec 14 17:00:48 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999524, encodeId=a2021999524d1, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Jul 30 04:09:00 CST 2015, time=2015-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25591, encodeId=92a425591c2, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:20:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25188, encodeId=1be825188f7, content=为我们研究AD提供了新的证据, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=559f1626469, createdName=youxnc, createdTime=Thu May 28 15:30:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25174, encodeId=3e6d251e40f, content=真的是脑子有病, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=Dr.LV, createdTime=Thu May 28 11:59:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25165, encodeId=9b2b2516593, content=人活着不容易啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=shazi111, createdTime=Thu May 28 11:04:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2017-12-14 wangyunyb

    我要收藏

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  2. [GetPortalCommentsPageByObjectIdResponse(id=269387, encodeId=7e2d26938e1f, content=我要收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170206/IMG589879E392F941842.jpg, createdBy=f4d469996, createdName=wangyunyb, createdTime=Thu Dec 14 17:00:48 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999524, encodeId=a2021999524d1, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Jul 30 04:09:00 CST 2015, time=2015-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25591, encodeId=92a425591c2, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:20:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25188, encodeId=1be825188f7, content=为我们研究AD提供了新的证据, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=559f1626469, createdName=youxnc, createdTime=Thu May 28 15:30:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25174, encodeId=3e6d251e40f, content=真的是脑子有病, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=Dr.LV, createdTime=Thu May 28 11:59:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25165, encodeId=9b2b2516593, content=人活着不容易啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=shazi111, createdTime=Thu May 28 11:04:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2015-07-30 yinhl1978
  3. [GetPortalCommentsPageByObjectIdResponse(id=269387, encodeId=7e2d26938e1f, content=我要收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170206/IMG589879E392F941842.jpg, createdBy=f4d469996, createdName=wangyunyb, createdTime=Thu Dec 14 17:00:48 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999524, encodeId=a2021999524d1, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Jul 30 04:09:00 CST 2015, time=2015-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25591, encodeId=92a425591c2, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:20:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25188, encodeId=1be825188f7, content=为我们研究AD提供了新的证据, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=559f1626469, createdName=youxnc, createdTime=Thu May 28 15:30:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25174, encodeId=3e6d251e40f, content=真的是脑子有病, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=Dr.LV, createdTime=Thu May 28 11:59:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25165, encodeId=9b2b2516593, content=人活着不容易啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=shazi111, createdTime=Thu May 28 11:04:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2015-05-31 huaxipanxing

    看看

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=269387, encodeId=7e2d26938e1f, content=我要收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170206/IMG589879E392F941842.jpg, createdBy=f4d469996, createdName=wangyunyb, createdTime=Thu Dec 14 17:00:48 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999524, encodeId=a2021999524d1, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Jul 30 04:09:00 CST 2015, time=2015-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25591, encodeId=92a425591c2, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:20:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25188, encodeId=1be825188f7, content=为我们研究AD提供了新的证据, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=559f1626469, createdName=youxnc, createdTime=Thu May 28 15:30:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25174, encodeId=3e6d251e40f, content=真的是脑子有病, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=Dr.LV, createdTime=Thu May 28 11:59:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25165, encodeId=9b2b2516593, content=人活着不容易啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=shazi111, createdTime=Thu May 28 11:04:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2015-05-28 youxnc

    为我们研究AD提供了新的证据

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=269387, encodeId=7e2d26938e1f, content=我要收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170206/IMG589879E392F941842.jpg, createdBy=f4d469996, createdName=wangyunyb, createdTime=Thu Dec 14 17:00:48 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999524, encodeId=a2021999524d1, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Jul 30 04:09:00 CST 2015, time=2015-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25591, encodeId=92a425591c2, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:20:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25188, encodeId=1be825188f7, content=为我们研究AD提供了新的证据, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=559f1626469, createdName=youxnc, createdTime=Thu May 28 15:30:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25174, encodeId=3e6d251e40f, content=真的是脑子有病, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=Dr.LV, createdTime=Thu May 28 11:59:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25165, encodeId=9b2b2516593, content=人活着不容易啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=shazi111, createdTime=Thu May 28 11:04:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2015-05-28 Dr.LV

    真的是脑子有病

    0

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    2015-05-28 shazi111

    人活着不容易啊

    0

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