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Gastrointest Endosc:新O型套扎环应用安全有效

2015-03-31 程芮 cmt

美国一项研究表明,已在猪模型上初步探索并证实,新O型套扎环应用于远端结肠憩室翻转和固定治疗安全、有效。文章发表于《消化内镜》杂志3月刊。消化道憩室的发病率逐年升高,特别是在西方国家,一部分严重患者会合并憩室炎、出血等并发症,针对经常发生上述并发症的患者可行开腹或腹腔镜下手术治疗,但对于年龄过大或有其他伴随疾病的患者行外科手术创伤性过大,因此,结肠镜下应用不同干预方法来治疗急性憩室炎及出血可以弥补这

美国一项研究表明,已在猪模型上初步探索并证实,新O型套扎环应用于远端结肠憩室翻转和固定治疗安全、有效。文章发表于《消化内镜》杂志3月刊。

消化道憩室的发病率逐年升高,特别是在西方国家,一部分严重患者会合并憩室炎、出血等并发症,针对经常发生上述并发症的患者可行开腹或腹腔镜下手术治疗,但对于年龄过大或有其他伴随疾病的患者行外科手术创伤性过大,因此,结肠镜下应用不同干预方法来治疗急性憩室炎及出血可以弥补这一不足,同时疗效显著,干预方法包括肾上腺素注射、热电凝、止血钳、内镜套扎等。对于开口很小的憩室或出血点位于憩室顶部的情况,应用止血钳进行止血难度较大,因此许多专家提议可进行套扎止血。但是,进行套扎止血有一些需要注意的问题:①目前应用的套扎设备主要是专用于食管静脉曲张治疗的,而没有针对结肠憩室出血治疗的特殊套扎设备;②套扎环随着结肠蠕动出现滑移现象;③吸引器型号、直径与憩室开口不匹配。因此,发明适用于治疗结肠憩室出血的特殊内镜设备迫在眉睫。

■研究简介

研究者通过分析人乙状结肠离体组织,采用盲法对憩室分布情况和形态特征进行评估,主要包括憩室的部位、数量、开口直径、深度、憩室壁厚度等。应用数码卡尺测量所有项目(0~150mm);应用吊秤测定憩室翻转所产生的张力。

结果显示,所有248例由尸体解剖分离出的乙状结肠均能应用负压吸引或钳取的方式进行憩室翻转,翻转所需要的力约0.28~0.47N。

研究者同时选用月龄3~4个月、体重35~45kg的母猪进行新O型套扎环治疗假性憩室的动物实验。首先人为造成动物远端结肠4个部位的假性憩室,腹腔内结肠段2个,腹腔外结直肠段2个。所应用的治疗设备经过特别设计:一条与真空泵相连的传输管路可翻转结肠壁,由2个同心管组成,外管直径12.2mm,用于释放组织套扎环(图1A)。套扎环由硅质橡胶制成,用于套在翻转的假性憩室上;为确保能牢牢固定在组织上,套扎环中间设计了4个钢质的尖头(图1B),经检测可承受200mmHg的压力。


        图1动物实验工具A:传输管路;B:套扎环,中间可见4个钢质尖头

手术过程为(图2):通过吸引结肠壁模拟假性憩室翻转,然后进行全结肠壁的抓取,厚度包括结肠壁全层。应用具有4个钢制尖头的套扎环圈套后,套扎处产生不可逆的缺血。紧贴套扎环上方穿入直杠铃型钉,将假性憩室顶端全层切除并行组织病理学分析,同时在该侧用聚丙烯缝线进行标记。最后,在腹腔镜观察下将结肠回纳,并记录影像(图3)。术后应用X线评估套扎环位置。所有动物术后均给予3天的抗生素预防感染,每周行影像学检查,直至所有套扎环脱落。最终对实验动物进行解剖,通过聚丙烯缝线标记寻找既往翻转的假性憩室部位,并将该部位组织行病理评估。


        图2A:选定套扎部位,吸引结肠黏膜;B:将O型环套扎在翻转的假性憩室黏膜上;C:穿入直杠铃型钉;D:将假性憩室的全层结肠壁剪下


        图3A:操作结束后的假性憩室;B、C:在腹腔镜观察下将结肠回纳(虚线圈处为假性憩室翻转部位)。D、E:术后应用X线评估套扎环的位置

研究者在6只活猪中共制造了24个翻转的假性憩室,应用了24个O型套扎环。其中1只动物于操作后死于肺栓塞,剩余情况如下:20个O型套扎环均在7天后脱落,12个在7~14天脱落,7个在14~21天脱落,1个在3周后脱落。后续进行动物解剖发现,无1例出现穿孔表现,全层组织愈合良好。

原始出处:

Amato G, Birsan T, Granic E, Agrusa A, Romano G,et al.Vacuum inversion and securing of distal colonic pseudodiverticula with novel spiked O-rings.Gastrointest Endosc. 2015 Mar;81(3):749-55. doi: 10.1016/j.gie.2014.09.051.

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    2015-05-02 lqvr
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1943392, encodeId=f7ec194339277, content=<a href='/topic/show?id=fa761e2916a' target=_blank style='color:#2F92EE;'>#Test#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17291, encryptionId=fa761e2916a, topicName=Test)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Sat May 02 21:42:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710790, encodeId=73b71e1079019, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Dec 19 12:42:00 CST 2015, time=2015-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050437, encodeId=3075205043eed, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Feb 12 19:42:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071578, encodeId=9d0820e1578c6, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Dec 11 17:42:00 CST 2015, time=2015-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19496, encodeId=4b5119496be, content=进步不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:19:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19493, encodeId=d8e81949331, content=这个号, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19494, encodeId=fe4b1949460, content=这个好, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19495, encodeId=f59a1949548, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=)]
    2015-12-11 许安
  5. [GetPortalCommentsPageByObjectIdResponse(id=1943392, encodeId=f7ec194339277, content=<a href='/topic/show?id=fa761e2916a' target=_blank style='color:#2F92EE;'>#Test#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17291, encryptionId=fa761e2916a, topicName=Test)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Sat May 02 21:42:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710790, encodeId=73b71e1079019, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Dec 19 12:42:00 CST 2015, time=2015-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050437, encodeId=3075205043eed, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Feb 12 19:42:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071578, encodeId=9d0820e1578c6, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Dec 11 17:42:00 CST 2015, time=2015-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19496, encodeId=4b5119496be, content=进步不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:19:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19493, encodeId=d8e81949331, content=这个号, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19494, encodeId=fe4b1949460, content=这个好, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19495, encodeId=f59a1949548, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=)]
    2015-04-05 清氺訫

    进步不错

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1943392, encodeId=f7ec194339277, content=<a href='/topic/show?id=fa761e2916a' target=_blank style='color:#2F92EE;'>#Test#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17291, encryptionId=fa761e2916a, topicName=Test)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Sat May 02 21:42:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710790, encodeId=73b71e1079019, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Dec 19 12:42:00 CST 2015, time=2015-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050437, encodeId=3075205043eed, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Feb 12 19:42:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071578, encodeId=9d0820e1578c6, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Dec 11 17:42:00 CST 2015, time=2015-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19496, encodeId=4b5119496be, content=进步不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:19:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19493, encodeId=d8e81949331, content=这个号, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19494, encodeId=fe4b1949460, content=这个好, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19495, encodeId=f59a1949548, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=)]
    2015-04-05 清氺訫

    这个号

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1943392, encodeId=f7ec194339277, content=<a href='/topic/show?id=fa761e2916a' target=_blank style='color:#2F92EE;'>#Test#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17291, encryptionId=fa761e2916a, topicName=Test)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Sat May 02 21:42:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710790, encodeId=73b71e1079019, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Dec 19 12:42:00 CST 2015, time=2015-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050437, encodeId=3075205043eed, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Feb 12 19:42:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071578, encodeId=9d0820e1578c6, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Dec 11 17:42:00 CST 2015, time=2015-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19496, encodeId=4b5119496be, content=进步不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:19:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19493, encodeId=d8e81949331, content=这个号, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19494, encodeId=fe4b1949460, content=这个好, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19495, encodeId=f59a1949548, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=)]
    2015-04-05 清氺訫

    这个好

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1943392, encodeId=f7ec194339277, content=<a href='/topic/show?id=fa761e2916a' target=_blank style='color:#2F92EE;'>#Test#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17291, encryptionId=fa761e2916a, topicName=Test)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Sat May 02 21:42:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710790, encodeId=73b71e1079019, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Dec 19 12:42:00 CST 2015, time=2015-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050437, encodeId=3075205043eed, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Feb 12 19:42:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071578, encodeId=9d0820e1578c6, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Dec 11 17:42:00 CST 2015, time=2015-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19496, encodeId=4b5119496be, content=进步不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:19:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19493, encodeId=d8e81949331, content=这个号, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19494, encodeId=fe4b1949460, content=这个好, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19495, encodeId=f59a1949548, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 09:18:00 CST 2015, time=2015-04-05, status=1, ipAttribution=)]
    2015-04-05 清氺訫

    值得学习

    0

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