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PeerJ:MicroRNA-705调节小鼠下颌骨骨髓间充质干细胞的分化

2019-01-26 MedSci MedSci原创

颅面骨骼是大多数口腔医学治疗的基础,包括口腔修复学和颌面外科。尽管在组织学上类似于附肢骨骼,但颅面骨骼表现出响应外部刺激和信号的许多独特性质。然而,下颌骨或上颌骨骨髓间充质是颅面骨骼功能的内在基础,尚未得到很好的研究,其稳态机制仍然难以捉摸。骨质疏松症是一种影响所有骨骼的全身性疾病,其特征在于骨量减少。骨质疏松性骨髓间充质干细胞(BMMSCs)表现出扰乱的体内平衡和扭曲的谱系定型。许多报道显示mi

颅面骨骼是大多数口腔医学治疗的基础,包括口腔修复学和颌面外科。尽管在组织学上类似于附肢骨骼,但颅面骨骼表现出响应外部刺激和信号的许多独特性质。然而,下颌骨或上颌骨骨髓间充质是颅面骨骼功能的内在基础,尚未得到很好的研究,其稳态机制仍然难以捉摸。骨质疏松症是一种影响所有骨骼的全身性疾病,其特征在于骨量减少。骨质疏松性骨髓间充质干细胞(BMMSCs)表现出扰乱的体内平衡和扭曲的谱系定型。许多报道显示microRNA(miRNA)在调节MSCs稳态中起重要作用。

在这里,为了更好地了解下颌骨骨髓间充质干细胞体内平衡,我们从小鼠下颌骨中分离并培养了下颌骨骨髓间充质干细胞。使用miR-705模拟物和抑制剂,我们证明miR-705在体外转移下颌骨MSCs谱系承诺中起着至关重要的作用。利用骨质疏松症小鼠模型,我们证明来自卵巢切除(OVX)小鼠下颌骨骨髓的MSC表现出成骨和过度脂肪形成分化受损。发现miR-705在OVX下颌骨MSC中过表达。通过上调成骨标志物基因的表达但抑制脂肪形成基因,体外敲除miR-705部分地减弱了OVX下颌骨MSC的分化紊乱。

总之,我们的研究结果提供了对下颌骨BMMSCs的稳态机制和治疗下颌骨骨质疏松症的新的潜在治疗靶点的更好理解。

原始出处:

Yang XH, Yang K, et al., MicroRNA-705 regulates the differentiation of mouse mandible bone marrow mesenchymal stem cells. PeerJ. 2019 Jan 10;7:e6279. doi: 10.7717/peerj.6279. eCollection 2019.

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    2019-07-02 sjzlzc007
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    2020-01-08 feather89
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content=<a href='/topic/show?id=e2dc2025888' target=_blank style='color:#2F92EE;'>#下颌骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20258, encryptionId=e2dc2025888, topicName=下颌骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f63514434, createdName=珙桐, createdTime=Mon Jan 28 05:09:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435745, encodeId=6bf51435e458d, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 28 05:09:00 CST 2019, time=2019-01-28, status=1, ipAttribution=)]
  5. 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content=<a href='/topic/show?id=e2dc2025888' target=_blank style='color:#2F92EE;'>#下颌骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20258, encryptionId=e2dc2025888, topicName=下颌骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f63514434, createdName=珙桐, createdTime=Mon Jan 28 05:09:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435745, encodeId=6bf51435e458d, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, 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  6. 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content=<a href='/topic/show?id=e2dc2025888' target=_blank style='color:#2F92EE;'>#下颌骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20258, encryptionId=e2dc2025888, topicName=下颌骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f63514434, createdName=珙桐, createdTime=Mon Jan 28 05:09:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435745, encodeId=6bf51435e458d, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 28 05:09:00 CST 2019, time=2019-01-28, status=1, ipAttribution=)]
    2019-05-09 xlysu
  7. 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content=<a href='/topic/show?id=e2dc2025888' target=_blank style='color:#2F92EE;'>#下颌骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20258, encryptionId=e2dc2025888, topicName=下颌骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f63514434, createdName=珙桐, createdTime=Mon Jan 28 05:09:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435745, encodeId=6bf51435e458d, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 28 05:09:00 CST 2019, time=2019-01-28, status=1, ipAttribution=)]
    2019-10-19 xjy02
  8. 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createdName=sjzlzc007, createdTime=Tue Jul 02 18:09:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727860, encodeId=fd3b1e27860d3, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 08 20:09:00 CST 2020, time=2020-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815444, encodeId=634b181544426, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Mon Sep 09 20:09:00 CST 2019, time=2019-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705505, encodeId=2e491e05505cf, content=<a href='/topic/show?id=31f9102015b3' target=_blank style='color:#2F92EE;'>#骨髓间充质干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102015, encryptionId=31f9102015b3, topicName=骨髓间充质干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723a30986413, createdName=ying_wu, createdTime=Mon Jan 06 20:09:00 CST 2020, time=2020-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699754, encodeId=0e4c1699e544b, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Thu May 09 09:09:00 CST 2019, time=2019-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084478, encodeId=cb4b20844e880, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Sat Oct 19 05:09:00 CST 2019, time=2019-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419643, encodeId=6e7e1419643cb, content=<a href='/topic/show?id=e2dc2025888' target=_blank style='color:#2F92EE;'>#下颌骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20258, encryptionId=e2dc2025888, topicName=下颌骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f63514434, createdName=珙桐, createdTime=Mon Jan 28 05:09:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435745, encodeId=6bf51435e458d, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 28 05:09:00 CST 2019, time=2019-01-28, status=1, ipAttribution=)]
    2019-01-28 珙桐
  9. [GetPortalCommentsPageByObjectIdResponse(id=1857745, encodeId=7032185e745e6, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Tue Jan 07 12:09:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786931, encodeId=5f131e86931f5, content=<a href='/topic/show?id=3bd213998ca' target=_blank style='color:#2F92EE;'>#peer#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13998, encryptionId=3bd213998ca, topicName=peer)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, 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content=<a href='/topic/show?id=e2dc2025888' target=_blank style='color:#2F92EE;'>#下颌骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20258, encryptionId=e2dc2025888, topicName=下颌骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f63514434, createdName=珙桐, createdTime=Mon Jan 28 05:09:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435745, encodeId=6bf51435e458d, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 28 05:09:00 CST 2019, time=2019-01-28, status=1, ipAttribution=)]
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