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Sci Rep：北京中医药大学在槐耳抗肿瘤机制研究取得进展

2017-04-29 佚名 北京中医药大学中药现代研究中心

槐耳中医药抗肿瘤
关注

化疗是肝癌晚期非常重要的治疗手段，但作用仍然有限。发现具有良好疗效且低毒性的肝癌治疗药物迫在眉睫。中药因疗效较好及毒副作用较低得到了患者的广泛肯定，正吸引越来越多的学者关注。槐耳为多孔菌科真菌槐栓菌 Trametes robiniophila Murr.的干燥子实体，作为传统中药在中国已有1600余年的历史。槐耳对癌症特别是肝癌治疗具有良好的疗效，但具体分子作用机制尚不甚明确。针对上述不足，本中心

化疗是肝癌晚期非常重要的治疗手段，但作用仍然有限。发现具有良好疗效且低毒性的肝癌治疗药物迫在眉睫。中药因疗效较好及毒副作用较低得到了患者的广泛肯定，正吸引越来越多的学者关注。槐耳为多孔菌科真菌槐栓菌 Trametes robiniophila Murr.的干燥子实体，作为传统中药在中国已有1600余年的历史。槐耳对癌症特别是肝癌治疗具有良好的疗效，但具体分子作用机制尚不甚明确。

针对上述不足，本中心胡仲冬博士和硕士研究生杨爱琳以人肝癌细胞SKHEP-1为模型进行了抗癌机制研究，发现槐耳清膏能明显抑制SKHEP-1细胞增殖，诱导其凋亡，并能显着抑制SKHEP-1细胞的迁移侵袭能力。在此基础上，通过基因芯片分析及相应的功能验证，揭示了槐耳清膏在人肝癌细胞SKHEP-1中能下调核纤层蛋白B1(Lamin B1)的表达，并增强基质细胞蛋白NOV的水平。该发现一定程度上解释了槐耳抑制人肝癌细胞增殖和侵袭的原因，为槐耳抗肝癌作用机制增添了新的内容，也为槐耳临床用药提供了新的科学依据，但槐耳清膏中具体哪类分子发挥作用，还有待于进一步研究。

本研究得到了国家自然科学基金（81403147）和北京中医药大学杰出青年人才等项目资助，相关成果发表于最近的《Scientific Reports》上，中心主任屠鹏飞教授为论文通讯作者。

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    2017-08-22 hbwxf

    #机制研究#

    0

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    2018-02-13 Tamikia

    #肿瘤机制#

    0

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    2017-05-01 cathymary

    #医药#

    0

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    2017-04-30 solarjin

    槐耳颗粒抗肿瘤赫赫有名呐

    0

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    2017-04-30 大爰

    好文章谢谢分享！！

    0

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    2017-04-30 jacob9231

    振奋人心，赞

    0

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    2017-04-30 lemon985

    学习

    0

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