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Ann Rheum Dis:风湿病患者感染新冠病毒的临床特征和预后

2020-05-27 xiangting MedSci原创

感染COVID-19的风湿病患者更可能需要机械通气,但其临床特征和住院率与非风湿病患者相似。

这项研究旨在探讨风湿病患者与非风湿病患者感染2019冠状病毒(COVID-19)后临床表现和预后的差异。

在马萨诸塞州大波士顿地区的合作医疗保健系统中,对感染COVID-19的风湿病患者(通过严重急性呼吸综合征冠状病毒2 PCR确诊)进行了一项比较队列研究,按1:2的比例与年龄、性别相匹配的对照进行比较,COVID-19的诊断日期是2020年3月1日至4月8日。分析了COVID-19感染的人口学、临床特征和结局差异。主要结局是住院、重症监护、机械通气和死亡。

共确定了52例感染COVID-19的风湿病患者(平均年龄63岁;女性占69%),并将其与104例非风湿病对照进行了匹配。大多数(39,75%)风湿病患者在使用免疫抑制药物。风湿病与非风湿病患者的症状和实验室检查结果相似。风湿病与非风湿病患者的住院比例相似(23(44%)vs 42(40%),p=0.50),但风湿病患者重症监护和机械通气的比例较高(11(48%) vs 7(18%),多因素OR 3.11(95%CI 1.07-9.05)。两组的死亡率相似(3(6%)vs 4(4%),p=0.69)。

感染COVID-19的风湿病患者更可能需要机械通气,但其临床特征和住院率与非风湿病患者相似。这些发现对风湿病患者具有重要意义,但需要进一步验证。

原始出处:

Kristin M D’Silva. Clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and rheumatic disease: a comparative cohort study from a US ‘hot spot. Ann Rheum Dis. 25 May 2020

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    2020-05-27 公卫新人

    新冠肺炎,疫情何时才能消失

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