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J Dent Res:MiR-361-3p/Nfat5信号轴调控成牙骨质细胞分化

2019-08-12 lishiting MedSci原创

牙周组织的发育是一个复杂的过程,包括成牙骨质细胞的增殖和分化。越来越多的研究显示,microRNAs (miRNAs)在调节众多生物进程的基因调控网络中起到重要作用。然而,miRNAs如何调节成牙骨质细胞增殖和分化还未可知。在之前的研究中,作者通过miRNA微点阵谱揭示了成牙骨质细胞分化中miRNA的完整表达模式。研究聚焦于在成牙骨质细胞分化过程中表达下调的miR-361-3p。

牙周组织的发育是一个复杂的过程,包括成牙骨质细胞的增殖和分化。越来越多的研究显示,microRNAs (miRNAs)在调节众多生物进程的基因调控网络中起到重要作用。然而,miRNAs如何调节成牙骨质细胞增殖和分化还未可知。在之前的研究中,作者通过miRNA微点阵谱揭示了成牙骨质细胞分化中miRNA的完整表达模式。研究聚焦于在成牙骨质细胞分化过程中表达下调的miR-361-3p。结果显示,过表达miR-361-3p减弱成牙骨质细胞的分化,而功能性抑制miR-361-3p则起到反转的效果。生物信息学结果显示,nuclear factor of activated T-cell 5 (Nfat5)是miR-361-3p的一个潜在靶点,通过双荧光素酶测定得以验证。同时,体内和体外研究验证了Nfat5的表达模式。另外,通过敲除Nfat5模拟成牙骨质细胞内过表达miR-361-3p的抑制作用。此外,在成牙骨质细胞内下调Nfat5或过表达miR-361-3p显著激活多重信号通路,包括:Erk1/2, JNK, p38, PI3K-Akt和NF-κB通路,也阻断了Wnt/?-catenin通路。最后

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    2019-12-27 smallant2002
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    2020-03-31 wolongzxh
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    2020-07-02 wumeihua99
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  8. [GetPortalCommentsPageByObjectIdResponse(id=1930727, encodeId=35061930e27f0, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Dec 27 04:18:00 CST 2019, time=2019-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006328, encodeId=26fd2006328a5, content=<a href='/topic/show?id=64782e31314' target=_blank style='color:#2F92EE;'>#信号轴#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27313, encryptionId=64782e31314, topicName=信号轴)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Thu Nov 21 09:18:00 CST 2019, time=2019-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778440, encodeId=c93b1e78440da, content=<a href='/topic/show?id=9ca312e4197' target=_blank style='color:#2F92EE;'>#NFAT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12741, encryptionId=9ca312e4197, topicName=NFAT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d5a439231063, createdName=wolongzxh, createdTime=Tue Mar 31 05:18:00 CST 2020, time=2020-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061051, encodeId=f626206105176, content=<a href='/topic/show?id=b3265404363' target=_blank style='color:#2F92EE;'>#成牙骨质细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54043, encryptionId=b3265404363, topicName=成牙骨质细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Tue Jun 16 15:18:00 CST 2020, time=2020-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029957, encodeId=f895202995e69, content=<a href='/topic/show?id=d493e259c9' target=_blank style='color:#2F92EE;'>#fat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7259, encryptionId=d493e259c9, topicName=fat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Sat Aug 24 05:18:00 CST 2019, time=2019-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722961, encodeId=a9a41e2296182, content=<a href='/topic/show?id=58a912e424e' target=_blank style='color:#2F92EE;'>#NFAT5#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12742, encryptionId=58a912e424e, topicName=NFAT5)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ddbd33327055, createdName=wumeihua99, createdTime=Thu Jul 02 05:18:00 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570278, encodeId=570d15e027887, content=<a href='/topic/show?id=a66ae7809b1' target=_blank style='color:#2F92EE;'>#细胞分化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77809, encryptionId=a66ae7809b1, topicName=细胞分化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=653c15636865, createdName=karmond, createdTime=Wed Aug 14 13:18:00 CST 2019, time=2019-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592587, encodeId=9095159258eae, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Wed Aug 14 13:18:00 CST 2019, time=2019-08-14, status=1, ipAttribution=)]
    2019-08-14 Eleven17
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