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Clin Trans Gastroenterology: 血清可溶性受体AGE(sRAGE)水平与不健康的生活方式和非酒精性脂肪性肝病相关

2019-06-26 不详 MedSci原创

非酒精性脂肪性肝病(NAFLD)已被证实与血清糖基化终产物(AGEs)呈正相关关系,而在一些小型研究中与AGE可溶性受体(sRAGE)呈负相关。因此,本项研究的目的是评估生活方式和sRAGE水平之间的关联以及sRAGE水平或AGEs摄入量与NAFLD,胰岛素抵抗(IR)和升高的丙氨酸氨基转移酶(ALT)之间的关联。

背景及目的:
非酒精性脂肪性肝病(NAFLD)已被证实与血清糖基化终产物(AGEs)呈正相关关系,而在一些小型研究中与AGE可溶性受体(sRAGE)呈负相关。因此,本项研究的目的是评估生活方式和sRAGE水平之间的关联以及sRAGE水平或AGEs摄入量与NAFLD,胰岛素抵抗(IR)和升高的丙氨酸氨基转移酶(ALT)之间的关联。

方法:
本项研究是一项横断面研究。研究人员对所纳入的患者进行了空腹血液测试和血清sRAGE水平检测。通过超声检查和稳态模型评估分别评估NAFLD和胰岛素抵抗水平。通过食物频率问卷测量营养摄入量,并计算膳食AGEs的摄入量。

结果:
本项研究共纳入743名受试者(男性占52.6%,平均年龄58.83±6.58岁,NAFLD占38.7%)。运动是低sRAGE水平的独立保护因素(优势比[OR] = 0.71,95%置信区间0.52-0.97,P = 0.031)。摄入红色或加工肉(OR = 1.01,1.04-2.21,P = 0.045; OR = 1.49,1.00-2.21,P= 0.048)与低sRAGE水平的增加的风险相关。低sRAGE水平与ALT升高(OR = 1.69,1.11-2.57,P = 0.014)独立相关。摄入大量膳食AGEs与IR相关(OR = 2.04,1.25-3.34 P = 0.004)。

讨论:
生活方式与sRAGE水平相关,同时低水平的sRAGE与NAFLD的发生和ALT升高有关。

原始出处:

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encodeId=109120e2601af, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Aug 16 00:56:00 CST 2019, time=2019-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504707, encodeId=45b81504e0712, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Jun 28 07:56:00 CST 2019, time=2019-06-28, status=1, ipAttribution=)]
  5. 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createdTime=Fri Jun 28 07:56:00 CST 2019, time=2019-06-28, status=1, ipAttribution=)]
    2020-05-20 bsmagic9140
  6. 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createdTime=Fri Jun 28 07:56:00 CST 2019, time=2019-06-28, status=1, ipAttribution=)]
    2020-04-15 qjddjq
  7. 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  8. 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createdTime=Fri Jun 28 07:56:00 CST 2019, time=2019-06-28, status=1, ipAttribution=)]
    2019-08-16 许安
  9. 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