JCLA：嗜中性粒细胞与淋巴细胞比值能预测早产儿晚期败血症吗

2018-05-31 MedSci MedSci原创

嗜中性粒细胞与淋巴细胞比率(NLR)是一种相对比较容易获得的生物标志物，该标志已被报道在成人试验中指示疾病的严重程度。本研究的目的是评估在考虑脓毒症原因的情况下，培养阳性率与NLR之间的关系，以及对活性药物的预测。将出生体重早产儿≤1500 g和/或≤32孕周的研究对象纳入本研究。所有婴儿的出生后临床和实验室均有脓毒症症状均为3天以上。根据血液培养结果，所有登记的婴儿被分为两组:经培养证

嗜中性粒细胞与淋巴细胞比率(NLR)是一种相对比较容易获得的生物标志物，该标志已被报道在成人试验中指示疾病的严重程度。本研究的目的是评估在考虑脓毒症原因的情况下，培养阳性率与NLR之间的关系，以及对活性药物的预测。

将出生体重早产儿≤1500 g和/或≤32孕周的研究对象纳入本研究。所有婴儿的出生后临床和实验室均有脓毒症症状均为3天以上。根据血液培养结果，所有登记的婴儿被分为两组:经培养证实的脓毒症婴儿和疑似脓毒症婴儿。NLR计算为嗜中性粒细胞计数与淋巴细胞计数之比。初步的实验室调查包括白细胞计数、血小板计数(PLT)、C‐反应蛋白(CRP)和血液培养。

结果显示，共有127名婴儿参与，其中57例经培养证实的脓毒症，另外75例疑似脓毒症。两组在胎龄、性别、出生体重、分娩方式、产后年龄等方面无显著差异。计算了NLR和CRP的ROC曲线。曲线下的面积与0.78±0.04(NLR)和0.55±0.05(CRP)。NLR的分界点为1.77，敏感性为0.73，特异性为0.78，准确率为0.76。

研究表明，NLR是一种简单、廉价、快速的方法，与CRP一起，在检测经培养证实的脓毒症，以及减少不必要的抗生物治疗方面更为有效。

原始出处：

Senem Alkan Ozdemir,Can neutrophil to lymphocyte ratio predict late‐onset sepsis in preterm infants?

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2019-02-07 ms6829001416292975

#嗜中性粒细胞#

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2018-06-02 yykkxiaodou

#中性粒细胞#

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2018-06-02 wetgdt

#淋巴细胞#

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2018-06-02 yfjms

学习

91 0
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2018-06-01 明月清辉

谢谢分享.学习了

87 0
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2018-06-01 飛歌

学习了很有用不错

98 0
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2018-06-01 1209e435m98(暂无昵称)

学习了.谢谢分享

0 0
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2018-06-01 wzb521zf

一起学习学习

79 0
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2018-06-01 lou.minghong

学习了谢谢分享!

64 0
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2018-06-01 yfjms

学习

103 0