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Diabetologia:12岁以下儿童出生体重,出生时胎龄与1型糖尿病之间的关联?

2018-04-12 MedSci MedSci原创

近日,国际杂志 《Diabetologia》上在线发表关于12岁以下儿童出生体重,出生时胎龄与后期患1型糖尿病之间的关联的一项1998-2012年在英国进行的回顾性队列研究的研究。 遗传学仅能够解释1型糖尿病风险的40-50%,但同时,早期生活中的环境风险因素也是1型糖尿病的风险因素。以前的研究发现1型糖尿病的出生时体重和出生时胎龄不一致。本研究旨在调查英国出生体重,出生时胎龄与随后的1型糖

近日,国际杂志 《Diabetologia》上在线发表关于12岁以下儿童出生体重,出生时胎龄与后期患1型糖尿病之间的关联的一项1998-2012年在英国进行的回顾性队列研究的研究。 遗传学仅能够解释1型糖尿病风险的40-50%,但同时,早期生活中的环境风险因素也是1型糖尿病的风险因素。以前的研究发现1型糖尿病的出生时体重和出生时胎龄不一致。本研究旨在调查英国出生体重,出生时胎龄与随后的1型糖尿病之间的关系。 本研究数据来自于一个由基于人口的数据库组成,该数据库使用1998年至2012年的英国国家医院疾病发作统计资料,包括相关的母婴成对数据。总共对3,834,405名按出生体重和出生时孕龄分类的儿童通过记录联系进行了跟踪,通过计算多变量校正后的HR来评估1型糖尿病的发病率。 研究发现,在3,834,405名儿童中,有2969名在随后童年中在医院被诊断为1型糖尿病。早产儿(<37周)或孕期(37-38周)的儿童发生1型糖尿病的发生率显著高于足月儿童(39-40周)(HR 1.19 [95%CI 1.03,1.38]和1.27 [95 %CI 1.16,1.39])。控制胎龄后出生时体

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