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STROKE:大脑中动脉钙化居然对症状性中脑动脉梗死有保护作用!

2017-09-27 MedSci MedSci原创

颅内动脉钙化与卒中风险增加密切相关。然而,钙化的动脉粥样硬化斑块也被认为是不容易破裂的。鉴于这种差异,近期,一项发表在杂志STROKE上的研究评估了颅内动脉粥样硬化的脆弱性是否因钙化的存在与否而不同。此项研究招募了单侧大脑中动脉(MCA)领域连续出现急性脑卒中的患者。任何狭窄的MCA患者均被纳入受试人群。症状性MCA被定义为与狭窄MCA相关的梗死的发生。在使用3维软件包的非对比薄截面计算机断层摄影

颅内动脉钙化与卒中风险增加密切相关。然而,钙化的动脉粥样硬化斑块也被认为是不容易破裂的。鉴于这种差异,近期,一项发表在杂志STROKE上的研究评估了颅内动脉粥样硬化的脆弱性是否因钙化的存在与否而不同。此项研究招募了单侧大脑中动脉(MCA)领域连续出现急性脑卒中的患者。任何狭窄的MCA患者均被纳入受试人群。症状性MCA被定义为与狭窄MCA相关的梗死的发生。在使用3维软件包的非对比薄截面计算机断层摄影图像上评估MCA中钙化的存在。广义估计方程用于比较有症状和无症状狭窄之间的钙化频率。最终,在533例患者中检查的1066个MCAs中,有645个MCAs狭窄。在645例狭窄的MCAs中,406例MCAs(62.9%)伴有症状。在36例MCAs中(5.6%)观察到钙化。在无症状组中更频繁地观察到MCA发生钙化(7.9% vs. 4.2%; P = 0.032)。在多变量分析中,在有症状组人群中,MCA动脉粥样硬化中钙化的发生率较低(优势比为0.46;95%置信区间,0.23-0.92; P = 0.027)。此项研究表明MCA中钙化的动脉粥样硬化患者具有较少的症状。原始出处:Baek JH, Y

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