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JAHA:长期酒精摄入与动脉硬化之间有关吗?

2017-02-21 xing.T MedSci原创

这项研究表明持续的大量饮酒与较高的心血管疾病的风险有关,尤其是男性,该研究也为酒精摄入量改变随着时间推移的潜在影响提供了新的见解。当捕获酒精纵向摄入模式时并没单独依赖于最近的摄入量,其讨论了额外的可能观点。

新的证据表明动脉硬化程度是心血管健康的一个重要标志,与酒精摄入量有关。然而,长期酒精摄入在动脉硬化随时间进展中的作用尚不清楚。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。研究人员通过一个纵向队列研究来评估了25年的酒精摄入量和随后的动脉硬化改变之间的相关性。

该研究的数据(n=3869;73%为男性)来自于英国公务员Whitehall II队列研究,在该研究中参与者完成了重复(每隔4-5年时间进行一次)的脉搏波速度测定来评估动脉硬化情况。重复的酒精摄入量测定被用来将参与者分成不同的酒精摄入类型,即酒精摄入的纵向变化。研究人员采用性别-分层线性混合-效应模型来探讨不同酒精摄入类型是否对脉搏波速度和随着时间推移动脉硬化进展之间关系有所影响。

研究人员发现长期大量饮酒>112g酒精/周的男性其基础脉搏波速度(b=0.26m/s;P=0.045)显著高于那些一直适度饮酒的参与者(1-112g酒精/周)。以往饮酒的男性动脉硬化程度表现出更加明显,相比于一贯适度饮酒者(b=0.11m/s,P=0.009)。在调整了体重指数、心率、平均动脉压、糖尿病、高密度脂蛋白和甘油三酯后的女性中,所有的相关性并不显著。

这项研究表明持续的大量饮酒与较高的心血管疾病的风险有关,尤其是男性,该研究也为酒精摄入量改变随着时间推移的潜在影响提供了新的见解。当收集酒精纵向摄入模式时并没单独依赖于最近的摄入量,其讨论了额外的可能观点。

原始出处:

Darragh O'Neill,  et al. Twenty‐Five‐Year Alcohol Consumption Trajectories and Their Association With Arterial Aging: A Prospective Cohort Study. JAHA.2017. https://doi.org/10.1161/JAHA.116.005288.

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    2017-02-21 我爱光明2009

    远离白酒

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2042896, encodeId=b82820428968b, content=<a href='/topic/show?id=981895492d6' target=_blank style='color:#2F92EE;'>#酒精摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95492, encryptionId=981895492d6, topicName=酒精摄入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=86b7385, createdName=lqrandywkz, createdTime=Sat Dec 23 11:16:00 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267396, encodeId=7029126e3966c, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Thu Feb 23 03:16:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177311, encodeId=a61d1e731124, content=远离白酒, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=83821977043, createdName=我爱光明2009, createdTime=Tue Feb 21 20:52:37 CST 2017, time=2017-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177286, encodeId=509c1e728661, content=学习签到,赚积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Tue Feb 21 14:49:29 CST 2017, time=2017-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177277, encodeId=37b01e727782, content=饮酒对心血管病有很大的危害!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/03/23/e29fc1c9854bd501e11f0bf32d1fcb88.jpg, createdBy=a9561996204, createdName=1e1b80f0m19(暂无匿称), createdTime=Tue Feb 21 12:53:18 CST 2017, time=2017-02-21, status=1, ipAttribution=)]
    2017-02-21 shaosai

    学习签到,赚积分

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2042896, encodeId=b82820428968b, content=<a href='/topic/show?id=981895492d6' target=_blank style='color:#2F92EE;'>#酒精摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95492, encryptionId=981895492d6, topicName=酒精摄入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=86b7385, createdName=lqrandywkz, createdTime=Sat Dec 23 11:16:00 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267396, encodeId=7029126e3966c, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Thu Feb 23 03:16:00 CST 2017, time=2017-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177311, encodeId=a61d1e731124, content=远离白酒, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=83821977043, createdName=我爱光明2009, createdTime=Tue Feb 21 20:52:37 CST 2017, time=2017-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177286, encodeId=509c1e728661, content=学习签到,赚积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Tue Feb 21 14:49:29 CST 2017, time=2017-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=177277, encodeId=37b01e727782, content=饮酒对心血管病有很大的危害!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/03/23/e29fc1c9854bd501e11f0bf32d1fcb88.jpg, createdBy=a9561996204, createdName=1e1b80f0m19(暂无匿称), createdTime=Tue Feb 21 12:53:18 CST 2017, time=2017-02-21, status=1, ipAttribution=)]
    2017-02-21 1e1b80f0m19(暂无匿称)

    饮酒对心血管病有很大的危害!!

    0

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