SCI REP:早期肺发育的新发现

2017-06-24 MedSci MedSci原创

对大多数早产儿来说，他们小小的体型并不会让生活变得艰难。而是他们肺部的发育，决定了生与死的区别。为了更好地了解肺部，帮助这些孩子，全国各地的科学家们正在共同研究在妊娠晚期和儿童早期发展中的人肺分子图谱。作为LungMAP项目的一部分，在美国能源部西北太平洋国家实验室的科学家们对肺的发展研究最为深入，已经从4000个细胞样本中表征了成千上万的脂质和蛋白质。由Charles Ansong领导的PNNL

对大多数早产儿来说，他们小小的体型并不会让生活变得艰难。而是他们肺部的发育，决定了生与死的区别。

为了更好地了解肺部，帮助这些孩子，全国各地的科学家们正在共同研究在妊娠晚期和儿童早期发展中的人肺分子图谱。作为LungMAP项目的一部分，在美国能源部西北太平洋国家实验室的科学家们对肺的发展研究最为深入，已经从4000个细胞样本中表征了成千上万的脂质和蛋白质。

由Charles Ansong领导的PNNL团队在科学报告中发表了两篇论文：

Geremy Clair和Paul Piehowski观察了在正常肺发育过程中，蛋白质在肺泡中是如何变化的，肺泡是气体交换的主要部位，即吸入氧气和排出二氧化碳的部位。研究小组对来自肺泡的4000个细胞的3400多种蛋白质进行了描述和跟踪，这些细胞在肺泡中产生了表面活性剂，这是肺部的一种重要物质，在早产儿中通常不起作用。

Sydney E. Dautel和Jennifer Kyle研究了婴儿出生后的成熟肺中脂肪的变化情况。脂类是表面活性剂中重要的元素，它们发挥了很多作用，包括防止肺塌陷。科学家们的研究是迄今为止对肺部脂质的最深入的研究之一，并分析了在正常的肺发展中脂质与肺的关系。

"我们希望开发出一种类似于肺部生物分子的身份证，这样我们就能知道特定的生物分子是在什么位置、什么时间出现的，以此来表明它在做什么。"Ansong说。

"肺不成熟是早产儿死亡和疾病的主要原因。如果我们能了解肺是如何发育的，也许我们可以利用这些信息来促进这些孩子的发育停滞。"他补充道。

原文出处： Geremy Clair et al. Spatially-Resolved Proteomics： Rapid Quantitative Analysis of Laser Capture Microdissected Alveolar Tissue Samples， Scientific Reports (2016).

Sydney E. Dautel et al. Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung， Scientific Reports (2017).

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2017-12-11 vera_1203

#新发现#

33 0
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2017-06-26 人间可客

谢谢分享，学习了

57 0
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2017-06-26 kane35

很有意义的发现，工作量很大。

58 0
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2017-06-25 西风染林

不算详细，但，也受教了，肺部的表面活性剂，其实就是成熟的肺部细胞的一种脂质分泌

46 0
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2017-06-25 neurowu

#发育#

42 0
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2017-06-24 drdentist

学习了，谢谢

41 0
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content=好好先进多研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sat Jun 24 07:49:40 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
2017-06-24 明月清辉

谢谢分享，学习了

57 0
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content=好好先进多研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sat Jun 24 07:49:40 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
2017-06-24 楠博One

学习谢谢分享

18 0
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2017-06-24 中医痴

不错的，学习了，谢谢分享！

24 0
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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicUw7yoAI4gptl6B3VGw6WZJ0uC02gdsRKGWuUVO3YSn6iagP9laH8FZIo3kTr5Xb9ricn6kqveJVs6FOWPec9yClJFkTXHtxSA/0, createdBy=a44f1685526, createdName=drdentist, createdTime=Sat Jun 24 08:52:46 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214728, encodeId=679d214e285e, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Jun 24 08:46:44 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214717, encodeId=5b5f214e1795, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sat Jun 24 08:32:49 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214700, encodeId=7566214e008f, content=不错的，学习了，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sat Jun 24 07:53:27 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214695, encodeId=dc90214695ca, content=好好先进多研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sat Jun 24 07:49:40 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
2017-06-24 zwjnj2

好好先进多研究

30 0