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Neurology：下颌下腺穿刺活检可评估帕金森病

2014-02-13 高晓方 译 医学论坛网

下颌下腺穿刺活检帕金森病
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美国一项研究表明，在帕金森病患者中通过下颌下腺穿刺活检评估Lewy型α-突触蛋白病(LTS)具有可行性。论文于2月5日在线发表于《神经病学》(Neurology)。 此项研究共纳入15例病史≥5年的帕金森病患者，并在门诊条件下实施下颌下腺经皮穿刺活检(18G或16G)。通过下唇小切口切除小唾液腺。利用福尔马林固定组织，对石蜡切片行磷酸化α-突触蛋白免疫组化染色，并对LTS征象进行评估。 结果显

美国一项研究表明，在帕金森病患者中通过下颌下腺穿刺活检评估Lewy型α-突触蛋白病(LTS)具有可行性。论文于2月5日在线发表于《神经病学》(Neurology)。

此项研究共纳入15例病史≥5年的帕金森病患者，并在门诊条件下实施下颌下腺经皮穿刺活检(18G或16G)。通过下唇小切口切除小唾液腺。利用福尔马林固定组织，对石蜡切片行磷酸化α-突触蛋白免疫组化染色，并对LTS征象进行评估。

结果显示，帕金森病患者平均年龄为68.7岁，平均病程为11.8年。12例穿刺活检具有可评估的镜下下颌下腺组织，其中9例(75%)具有LTS。15例小唾液腺活检组织中仅有1例(6.7%)为LTS阳性。5例患者出现不良事件，均较轻微并为一过性。

原始出处：

Adler CH, Dugger BN, Hinni ML, Lott DG, Driver-Dunckley E, Hidalgo J, Henry-Watson J, Serrano G, Sue LI, Nagel T, Duffy A, Shill HA, Akiyama H, Walker DG, Beach TG.Submandibular gland needle biopsy for the diagnosis of Parkinson disease.Neurology. 2014 Feb 5.

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    2014-11-07 yinhl1978

    #Neurol#

    0

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    2014-09-03 xiangyuzhou981

    #下颌下腺穿刺活检#

    0

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    2014-07-10 xlysu

    #下颌#

    0

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    2015-01-15 lvygwyt2792

    #颌下腺#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1999374, encodeId=8a6e19993e4ae, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Nov 07 08:30:00 CST 2014, time=2014-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703548, encodeId=651b1e035484f, content=<a href='/topic/show?id=44cf20243b7' target=_blank style='color:#2F92EE;'>#下颌下腺穿刺活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20243, encryptionId=44cf20243b7, topicName=下颌下腺穿刺活检)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9a930519158, createdName=xiangyuzhou981, createdTime=Wed Sep 03 18:30:00 CST 2014, time=2014-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699674, encodeId=29f716996e4cd, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Thu Jul 10 17:30:00 CST 2014, time=2014-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1716590, encodeId=0fd81e165902f, content=<a href='/topic/show?id=56d41006816f' target=_blank style='color:#2F92EE;'>#颌下腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100681, encryptionId=56d41006816f, topicName=颌下腺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3bf32257172, createdName=lvygwyt2792, createdTime=Thu Jan 15 19:30:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9557, encodeId=77f4955ecf, content=需要大样本实验来做支撑, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd8745120, createdName=iwithyou, createdTime=Tue May 20 23:55:00 CST 2014, time=2014-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005293, encodeId=4e4a200529392, content=<a href='/topic/show?id=0f4de5432ce' target=_blank style='color:#2F92EE;'>#穿刺活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75432, encryptionId=0f4de5432ce, topicName=穿刺活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c2e485, createdName=yangfl06, createdTime=Fri Oct 17 10:30:00 CST 2014, time=2014-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1277945, encodeId=051612e79459d, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sat Feb 15 04:30:00 CST 2014, time=2014-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311854, encodeId=b7c5131185429, content=<a href='/topic/show?id=21a6e54280e' target=_blank style='color:#2F92EE;'>#穿刺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75428, encryptionId=21a6e54280e, topicName=穿刺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b48400, createdName=rgjl, createdTime=Sat Feb 15 04:30:00 CST 2014, time=2014-02-15, status=1, ipAttribution=)]
    2014-05-20 iwithyou

    需要大样本实验来做支撑

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1999374, encodeId=8a6e19993e4ae, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Nov 07 08:30:00 CST 2014, time=2014-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703548, encodeId=651b1e035484f, content=<a href='/topic/show?id=44cf20243b7' target=_blank style='color:#2F92EE;'>#下颌下腺穿刺活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20243, encryptionId=44cf20243b7, topicName=下颌下腺穿刺活检)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9a930519158, createdName=xiangyuzhou981, createdTime=Wed Sep 03 18:30:00 CST 2014, time=2014-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699674, encodeId=29f716996e4cd, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Thu Jul 10 17:30:00 CST 2014, time=2014-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1716590, encodeId=0fd81e165902f, content=<a href='/topic/show?id=56d41006816f' target=_blank style='color:#2F92EE;'>#颌下腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100681, encryptionId=56d41006816f, topicName=颌下腺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3bf32257172, createdName=lvygwyt2792, createdTime=Thu Jan 15 19:30:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9557, encodeId=77f4955ecf, content=需要大样本实验来做支撑, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd8745120, createdName=iwithyou, createdTime=Tue May 20 23:55:00 CST 2014, time=2014-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005293, encodeId=4e4a200529392, content=<a href='/topic/show?id=0f4de5432ce' target=_blank style='color:#2F92EE;'>#穿刺活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75432, encryptionId=0f4de5432ce, topicName=穿刺活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c2e485, createdName=yangfl06, createdTime=Fri Oct 17 10:30:00 CST 2014, time=2014-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1277945, encodeId=051612e79459d, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sat Feb 15 04:30:00 CST 2014, time=2014-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311854, encodeId=b7c5131185429, content=<a href='/topic/show?id=21a6e54280e' target=_blank style='color:#2F92EE;'>#穿刺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75428, encryptionId=21a6e54280e, topicName=穿刺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b48400, createdName=rgjl, createdTime=Sat Feb 15 04:30:00 CST 2014, time=2014-02-15, status=1, ipAttribution=)]
    2014-10-17 yangfl06

    #穿刺活检#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1999374, encodeId=8a6e19993e4ae, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Nov 07 08:30:00 CST 2014, time=2014-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703548, encodeId=651b1e035484f, content=<a href='/topic/show?id=44cf20243b7' target=_blank style='color:#2F92EE;'>#下颌下腺穿刺活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20243, encryptionId=44cf20243b7, topicName=下颌下腺穿刺活检)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9a930519158, createdName=xiangyuzhou981, createdTime=Wed Sep 03 18:30:00 CST 2014, time=2014-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699674, encodeId=29f716996e4cd, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Thu Jul 10 17:30:00 CST 2014, time=2014-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1716590, encodeId=0fd81e165902f, content=<a href='/topic/show?id=56d41006816f' target=_blank style='color:#2F92EE;'>#颌下腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100681, encryptionId=56d41006816f, topicName=颌下腺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3bf32257172, createdName=lvygwyt2792, createdTime=Thu Jan 15 19:30:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9557, encodeId=77f4955ecf, content=需要大样本实验来做支撑, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd8745120, createdName=iwithyou, createdTime=Tue May 20 23:55:00 CST 2014, time=2014-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005293, encodeId=4e4a200529392, content=<a href='/topic/show?id=0f4de5432ce' target=_blank style='color:#2F92EE;'>#穿刺活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75432, encryptionId=0f4de5432ce, topicName=穿刺活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c2e485, createdName=yangfl06, createdTime=Fri Oct 17 10:30:00 CST 2014, time=2014-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1277945, encodeId=051612e79459d, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sat Feb 15 04:30:00 CST 2014, time=2014-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311854, encodeId=b7c5131185429, content=<a href='/topic/show?id=21a6e54280e' target=_blank style='color:#2F92EE;'>#穿刺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75428, encryptionId=21a6e54280e, topicName=穿刺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b48400, createdName=rgjl, createdTime=Sat Feb 15 04:30:00 CST 2014, time=2014-02-15, status=1, ipAttribution=)]
    2014-02-15 smlt2008

    #活检#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1999374, encodeId=8a6e19993e4ae, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Nov 07 08:30:00 CST 2014, time=2014-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703548, encodeId=651b1e035484f, content=<a href='/topic/show?id=44cf20243b7' target=_blank style='color:#2F92EE;'>#下颌下腺穿刺活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20243, encryptionId=44cf20243b7, topicName=下颌下腺穿刺活检)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9a930519158, createdName=xiangyuzhou981, createdTime=Wed Sep 03 18:30:00 CST 2014, time=2014-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699674, encodeId=29f716996e4cd, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Thu Jul 10 17:30:00 CST 2014, time=2014-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1716590, encodeId=0fd81e165902f, content=<a href='/topic/show?id=56d41006816f' target=_blank style='color:#2F92EE;'>#颌下腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100681, encryptionId=56d41006816f, topicName=颌下腺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3bf32257172, createdName=lvygwyt2792, createdTime=Thu Jan 15 19:30:00 CST 2015, time=2015-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=9557, encodeId=77f4955ecf, content=需要大样本实验来做支撑, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd8745120, createdName=iwithyou, createdTime=Tue May 20 23:55:00 CST 2014, time=2014-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005293, encodeId=4e4a200529392, content=<a href='/topic/show?id=0f4de5432ce' target=_blank style='color:#2F92EE;'>#穿刺活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75432, encryptionId=0f4de5432ce, topicName=穿刺活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c2e485, createdName=yangfl06, createdTime=Fri Oct 17 10:30:00 CST 2014, time=2014-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1277945, encodeId=051612e79459d, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Sat Feb 15 04:30:00 CST 2014, time=2014-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1311854, encodeId=b7c5131185429, content=<a href='/topic/show?id=21a6e54280e' target=_blank style='color:#2F92EE;'>#穿刺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75428, encryptionId=21a6e54280e, topicName=穿刺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b48400, createdName=rgjl, createdTime=Sat Feb 15 04:30:00 CST 2014, time=2014-02-15, status=1, ipAttribution=)]
    2014-02-15 rgjl

    #穿刺#

    0

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