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Clin Nutr:帕金森病患者的饮食习惯与神经功能

2016-08-07 Mechront 译 MedSci原创

目的:从适当的营养保健尤其是饮食方面,帕金森氏病患者可以受益很大。然而,关于饮食习惯对帕金森氏症患者疾病功能影响的证据有限。方法:我们进行了一项大的病例对照研究。PD患者(n = 600)接受了系统的营养保健,根据年龄、性别、教育、运动情况和66项食物频率问卷调查结果匹配了健康对照组(n = 600)。调查患者的饮食习惯和PD患者以下特征的联系:体重、能量平衡、便秘、左旋多巴治疗(剂量)和左旋多巴

目的:从适当的营养保健尤其是饮食方面,帕金森氏病患者可以受益很大。然而,关于饮食习惯对帕金森氏症患者疾病功能影响的证据有限。

方法:我们进行了一项大的病例对照研究。PD患者(n = 600)接受了系统的营养保健,根据年龄、性别、教育、运动情况和66项食物频率问卷调查结果匹配了健康对照组(n = 600)。调查患者的饮食习惯和PD患者以下特征的联系:体重、能量平衡、便秘、左旋多巴治疗(剂量)和左旋多巴相关的运动并发症。

结果:相比对照组,帕金森氏症患者有更低的BMI,更高的食物摄入量。BMI与疾病的持续时间、严重程度和左旋多巴相关的运动并发症呈负相关;能量摄入与这些变量呈正相关。在生理需求范围内增加10克蛋白质摄入量(0.8克/公斤/天),左旋多巴剂量对应增加0.7毫克/公斤/天。便秘也与更高左旋多巴需求相关。最后,蛋白质摄入量及其一天中的分布也会影响左旋多巴相关的运动并发症。

结论:蛋白质摄入和便秘治疗的管理应被视为帕金森病患者护理的一个组成部分。注意力应始终集中在能量摄入上,维持营养状态,优化左旋多巴的治疗,最小化左旋多巴相关的运动并发症。

原始出处:


Barichella M.et al.Dietary habits and neurological features of Parkinson's disease patients: Implications for practice.Clin Nutr. 2016 Jul 5. pii: S0261-5614(16)30155-8. doi: 10.1016/j.clnu.2016.06.020

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    2016-10-09 ylzr123

    学习了,文章有深度,值得探究。

    0

  3. 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  4. 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likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:56:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102848, encodeId=b09010284873, content=又是饮食,喝酒会不会?, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Wed Aug 24 10:01:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99454, encodeId=512199454c1, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-09-15 ylzr123

    好文章,赞一个!深入学习,探究。

    0

  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-09-09 1e10c84am36(暂无匿称)

    赞!好文章,拜读,深入学习。

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-09-03 李东泽

    很好,不错,以后会多学习

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-08-24 liusanxin

    又是饮食,喝酒会不会?

    0

  8. 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likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:56:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102848, encodeId=b09010284873, content=又是饮食,喝酒会不会?, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387c1637569, createdName=liusanxin, createdTime=Wed Aug 24 10:01:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99454, encodeId=512199454c1, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-08-16 忠诚向上

    好好学习一下

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-08-16 huiminghappy

    饮食习惯很重要!

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 16 18:06:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99044, encodeId=017499044cf, content=饮食习惯很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:24:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97114, encodeId=d0949e1140a, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 09 18:37:00 CST 2016, time=2016-08-09, status=1, ipAttribution=)]
    2016-08-09 忠诚向上

    好好学习

    0

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导读:你以为单侧起病、“N”字形发展、静止性震颤、肌强直、行动迟缓就是帕金森诊断的全部?事实并非如此,帕金森的诊断是陷阱重重,充满挑战! 6月2日,第四军医大学西京医院刘学东老师在“医生站”为站友带来《帕金森病最新诊断标准2015解读》的精彩讲座,详细分析了帕金森病(PD)诊断的各种问题,内容精彩有料,小编特整理出这份听课笔记,希望对大家有用。 关于PD的诊断,有一个非常神

抗癌药有望治疗帕金森?诺华将开展Tasigna 帕金森症临床试验

制药巨头诺华将开展抗癌药Tasigna (nilotinib)的一项新适应症的临床试验,让人意外的是这并不是另一种实体瘤,而是帕金森症。 据悉这项临床试验将于明年开展,诺华将和Michael J. Fox基金会、Van Andel研究所以及Cure Parkinson等三家机构合作。目前诺华已经开展了一项为期6个月的I期安全性试验,还未验证Tasigna (nilotinib)治疗帕金森症的

Sci Rep:新诊断的贫血增加帕金森病的风险

贫血和低血红蛋白已被确定可增加帕金森氏病(PD)的风险。利用台湾全民健康保险研究数据库的数据,研究基于人群的队列中新确诊的贫血的患者发生PD的风险。所有新诊断的贫血患者(n = 86334  )无卒中病史、神经退行性疾病、脑外伤、大手术、或出血性疾病。一组为非贫血患者为对照组,在人口统计学和预先存在的医疗条件的基础上,按照1:1与贫血患者进行配对。竞争风险分析评估贫血患者和对照组PD发生的风险。贫

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近日,葡萄牙著名制药公司Bial研发的新型日服一次的帕金森症药物Ongentys (opicapone) 获得欧盟委员会批准,这是继今年1月份Bial公司发生临床试验事故后,收获的一则重大利好消息。 Ongentys (opicapone)被批准作为左旋多巴/多巴脱羧酶抑制剂的辅助治疗制剂,用于患有神经退行性运动障碍帕金森症的成人患者,以及那些以目前的疗法无法稳定控制病情的帕金森症患者。Bial

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