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Stem cells:干细胞移植在合并糖尿病的心脏病患者中的治疗潜能。

2017-07-10 qinqiyun MedSci原创

干细胞移植是一种可提高缺血性心脏病(IHD)患者心功能的具有潜力的再生性治疗方案。但因为糖尿病患者的干细胞的再生潜能进行性下降,这一方案在治疗合并糖尿病的IHD患者上受到限制。

干细胞移植是一种可提高缺血性心脏病(IHD)患者心功能的具有潜力的再生性治疗方案。但因为糖尿病患者的干细胞的再生潜能进行性下降,这一方案在治疗合并糖尿病的IHD患者上受到限制。

干细胞再生潜能的下降主要是因为干细胞集及其系统性诱因受高糖尿影响所形成的代谢记忆。理解了高血糖诱导干细胞功能下降的分子信号通路对于发展新的心脏再生疗法至关重要。

本文中,研究人员首先探讨了在糖尿病干扰后的干细胞中普遍发生的分子变化。然后集中于在糖尿病环境中失调并阻碍干细胞活化的关键信号通路,该条信号通路对于移植的或内源性干细胞迁徙到受损部位的过程至关重要。此外,研究人员进一步验证可以提高干细胞再生的效率的糖尿病患者的心脏干细胞(CPC)的可能的预处理方法。最后,研究人员建议一种新的利用基因或组织工程学来增强糖尿病患者的CPC的方法,其可以促进自体治疗方案的发展,提高糖尿病患者的心脏干细胞的增殖、血管生成和心脏特性。

原始出处:

Venkata R.Satthenapalli,Regis R.Lamberts,Rajesh G.Katare.Concise Review: Challenges in Regenerating the Diabetic Heart: A Comprehensive Review.Stem cells.6 July 2017.http://dx.doi.org/10.1002/stem.2661.

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    2017-10-20 维他命
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β受体阻滞剂类药物通常用于治疗各种心血管疾病,如心律失常和心力衰竭。在过去的几十年里,科学家已经知道,β受体阻滞剂类药物通过减缓心率并减少收缩力来减轻心脏负担。 然而,纽约大学的一项新研究显示,这些药物也扭转了许多与心脏病相关的潜在有害遗传变化,研究成果今日发表在国际期刊“Nature Scientific Reports”上。

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