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Am J Clin Nutr:尿钾排泄与心血管事件有没有关系?

2016-03-20 Mechront 译 MedSci原创

研究者对7795名没有心血管疾病的参与者进行了一项研究,探究尿钾排泄和心血管结局(心血管疾病(CVD)、缺血性心脏病(IHD)、卒中和新发房颤(HF))的关系。研究者分别分析了参与者纳入研究时(1997-1998年)和随访期间(2001-2003年)的24小时尿液样本中尿钾排泄情况。研究数据显示,纳入研究时参与者尿钾排泄为70 mmol/24 h (IQR: 56-84 mmol/24 h),中位

研究者对7795名没有心血管疾病的参与者进行了一项研究,探究尿钾排泄和心血管结局(心血管疾病(CVD)、缺血性心脏病(IHD)、卒中和新发房颤(HF))的关系。研究者分别分析了参与者纳入研究时(1997-1998年)和随访期间(2001-2003年)的24小时尿液样本中尿钾排泄情况。

研究数据显示,纳入研究时参与者尿钾排泄为70 mmol/24 h (IQR: 56-84 mmol/24 h),中位数随访10.5年(IQR: 9.9-10.8年)期间,共发生了641例CVD、465例IHD、172例卒中和265例HF。

校正年龄和性别后,尿钾排泄与CVD和IHD的风险呈反相关:尿钾排泄每增加26-mmol/24-h (1-g/d),HR(CVD)=0.87; 95% CI:0.78, 0.97;HR(IHD)=0.86; 95% CI:0.75, 0.97。没有发现尿钾排泄与卒中和HF间的关系:尿钾排泄每增加26-mmol/24-h (1-g/d),HR(卒中)=0.85; 95% CI:0.68, 1.06;HR(HF)=0.94; 95% CI:0.80, 1.10。

校正BMI、吸烟、饮酒、教育程度和尿钠、镁排泄后,没有发现尿钾排泄与CVD、IHD、卒中和HF间的关系:尿钾排泄每增加1-g/d,HR(CVD)=0.96; 95% CI:0.85, 1.09;HR(IHD)=0.90; 95% CI:0.81, 1.04;HR(卒中)=1.09; 95% CI:0.86, 1.39;HR(HF)=0.99; 95% CI:0.83, 1.18。尿钠/钾排泄比例与CVD、IHD、卒中和HF之间也没有联系。

研究结果表明,尿钾排泄情况与CVD、IHD、卒中和HF无关。

原始出处:

Kieneker LM, Gansevoort RT,et al.Urinary potassium excretion and risk of cardiovascular events.Am J Clin Nutr. 2016 Mar 16. pii: ajcn106773.


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    2016-10-17 维他命
  2. [GetPortalCommentsPageByObjectIdResponse(id=1743847, encodeId=99201e4384756, content=<a href='/topic/show?id=9b185665065' target=_blank style='color:#2F92EE;'>#排泄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56650, encryptionId=9b185665065, topicName=排泄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d01c35235377, createdName=维他命, createdTime=Mon Oct 17 19:50:00 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643400, encodeId=1480164340030, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Thu Apr 07 22:50:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73663, encodeId=308fe366330, content=感谢梅斯学院分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160319/IMG56EC9696F32B05996.jpg, createdBy=0eac1630810, createdName=moonlight1, createdTime=Thu Mar 24 22:53:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73021, encodeId=22dae3021e8, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Mar 23 17:41:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72786, encodeId=fbbce2786cc, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Wed Mar 23 00:45:00 CST 2016, time=2016-03-23, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1743847, encodeId=99201e4384756, content=<a href='/topic/show?id=9b185665065' target=_blank style='color:#2F92EE;'>#排泄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56650, encryptionId=9b185665065, topicName=排泄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d01c35235377, createdName=维他命, createdTime=Mon Oct 17 19:50:00 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643400, encodeId=1480164340030, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Thu Apr 07 22:50:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73663, encodeId=308fe366330, content=感谢梅斯学院分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160319/IMG56EC9696F32B05996.jpg, createdBy=0eac1630810, createdName=moonlight1, createdTime=Thu Mar 24 22:53:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73021, encodeId=22dae3021e8, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Mar 23 17:41:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72786, encodeId=fbbce2786cc, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Wed Mar 23 00:45:00 CST 2016, time=2016-03-23, status=1, ipAttribution=)]
    2016-03-24 moonlight1

    感谢梅斯学院分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1743847, encodeId=99201e4384756, content=<a href='/topic/show?id=9b185665065' target=_blank style='color:#2F92EE;'>#排泄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56650, encryptionId=9b185665065, topicName=排泄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d01c35235377, createdName=维他命, createdTime=Mon Oct 17 19:50:00 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643400, encodeId=1480164340030, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Thu Apr 07 22:50:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73663, encodeId=308fe366330, content=感谢梅斯学院分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160319/IMG56EC9696F32B05996.jpg, createdBy=0eac1630810, createdName=moonlight1, createdTime=Thu Mar 24 22:53:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73021, encodeId=22dae3021e8, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Mar 23 17:41:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72786, encodeId=fbbce2786cc, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Wed Mar 23 00:45:00 CST 2016, time=2016-03-23, status=1, ipAttribution=)]
    2016-03-23 dhzzm

    学习了,很好

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1743847, encodeId=99201e4384756, content=<a href='/topic/show?id=9b185665065' target=_blank style='color:#2F92EE;'>#排泄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56650, encryptionId=9b185665065, topicName=排泄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d01c35235377, createdName=维他命, createdTime=Mon Oct 17 19:50:00 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643400, encodeId=1480164340030, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Thu Apr 07 22:50:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73663, encodeId=308fe366330, content=感谢梅斯学院分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160319/IMG56EC9696F32B05996.jpg, createdBy=0eac1630810, createdName=moonlight1, createdTime=Thu Mar 24 22:53:00 CST 2016, time=2016-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73021, encodeId=22dae3021e8, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Mar 23 17:41:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72786, encodeId=fbbce2786cc, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44b91679772, createdName=1de304d2m86(暂无匿称), createdTime=Wed Mar 23 00:45:00 CST 2016, time=2016-03-23, status=1, ipAttribution=)]
    2016-03-23 1de304d2m86(暂无匿称)

    值得学习

    0

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