Baidu
map

Stroke:老年睡眠呼吸暂停患者卒中发病率增加

2018-12-14 xing.T MedSci原创

由此可见,在未治疗的严重OSA的老年患者中,卒中发生率而非冠心病发病率有所增加。适当的CPAP治疗可以降低这种风险。

年龄对阻塞性睡眠呼吸暂停(OSA)与血管事件发生率之间关系的影响仍存在争议。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员试图分析一大群老年患者OSA与卒中和冠心病发病率之间的关系,以及研究持续气道正压通气(CPAP)治疗在这些关联中的作用。

研究人员对2个西班牙大学医院中连续就诊的怀疑为OSA的≥65岁的患者中进行的前瞻性观察研究进行了事后分析。呼吸暂停-低通气指数(AHI)<15的患者为对照组。OSA定义为AHI≥15并归类为未治疗(未接受CPAP或依从性<4小时/天),轻度-中度(AHI为15-29),未治疗的严重(AHI≥30)和CPAP治疗(AHI≥15和CPAP依从性≥4小时/天)的患者。

859名和794名老年患者分别被纳入卒中和冠心病分析。随访时间中位数(四分位数间)分别为72(50-88.5)和71(51.5-89)个月。与对照组相比,未治疗的严重OSA组、CPAP治疗组和未治疗的轻度-中度OSA组患者卒中发生率的完全调整风险比分别为3.42(95%CI为1.37-8.52)、1.02(95%CI为0.41-2.56)和1.76(95%CI为0.62-4.97)。在其他不同的OSA组中未观察到与冠心病发病率之间存在关联。

由此可见,在未治疗的严重OSA的老年患者中,卒中发生率而非冠心病发病率有所增加。适当的CPAP治疗可以降低这种风险。

原始出处:

Pablo Catalan-Serra,et al.Increased Incidence of Stroke, but Not Coronary Heart Disease, in Elderly Patients With Sleep Apnea Role of Continuous Positive Airway Pressure Treatment.Stroke. 2018.https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.023353

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1823512, encodeId=da5a1823512ac, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Dec 16 05:43:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989113, encodeId=7f8c1989113d5, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sun Nov 10 00:43:00 CST 2019, time=2019-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355866, encodeId=912435586677, content=老年睡眠呼吸暂停患者。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Dec 19 20:11:26 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596558, encodeId=6be415965583c, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Sun Dec 16 10:43:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026237, encodeId=8037102623e1f, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Dec 14 22:43:00 CST 2018, time=2018-12-14, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1823512, encodeId=da5a1823512ac, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Dec 16 05:43:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989113, encodeId=7f8c1989113d5, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sun Nov 10 00:43:00 CST 2019, time=2019-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355866, encodeId=912435586677, content=老年睡眠呼吸暂停患者。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Dec 19 20:11:26 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596558, encodeId=6be415965583c, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Sun Dec 16 10:43:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026237, encodeId=8037102623e1f, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Dec 14 22:43:00 CST 2018, time=2018-12-14, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1823512, encodeId=da5a1823512ac, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Dec 16 05:43:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989113, encodeId=7f8c1989113d5, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sun Nov 10 00:43:00 CST 2019, time=2019-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355866, encodeId=912435586677, content=老年睡眠呼吸暂停患者。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Dec 19 20:11:26 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596558, encodeId=6be415965583c, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Sun Dec 16 10:43:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026237, encodeId=8037102623e1f, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Dec 14 22:43:00 CST 2018, time=2018-12-14, status=1, ipAttribution=)]
    2018-12-19 jyzxjiangqin

    老年睡眠呼吸暂停患者。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1823512, encodeId=da5a1823512ac, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Dec 16 05:43:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989113, encodeId=7f8c1989113d5, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sun Nov 10 00:43:00 CST 2019, time=2019-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355866, encodeId=912435586677, content=老年睡眠呼吸暂停患者。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Dec 19 20:11:26 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596558, encodeId=6be415965583c, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Sun Dec 16 10:43:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026237, encodeId=8037102623e1f, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Dec 14 22:43:00 CST 2018, time=2018-12-14, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1823512, encodeId=da5a1823512ac, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Dec 16 05:43:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989113, encodeId=7f8c1989113d5, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sun Nov 10 00:43:00 CST 2019, time=2019-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355866, encodeId=912435586677, content=老年睡眠呼吸暂停患者。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Dec 19 20:11:26 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596558, encodeId=6be415965583c, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Sun Dec 16 10:43:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026237, encodeId=8037102623e1f, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Dec 14 22:43:00 CST 2018, time=2018-12-14, status=1, ipAttribution=)]
    2018-12-14 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

相关资讯

BMJ:海鲜中的长链不饱和脂肪酸有助于老年人群健康

研究认为来 补充来自海产品中的二十碳五烯酸和二十二碳五烯酸可降低老年人群疾病风险,但海鲜中的二十二碳六烯酸和植物中的α-亚麻酸则与老年健康不相关

JAHA:步态速度与老年患者心脏手术后死亡率相关

在接受过心脏外科手术的老年人中,危险因素的预测很重要。本研究的目的旨在评估步态速度与1年死亡率和再住院风险的相关性。本研究纳入了8287名接受过心脏手术的患者,平均年龄74岁,女性占32%。1年后的生存率在慢速组(<0.83 m/s)、中速组(0.83–1.00 m/s)和快速组(>1.00 m/s)分别是90%、95%和97%,住院风险分别是45%、33%和27%(P<0.00

J Bone Miner Res:老年黑人女性补充维生素D能否预防骨流失?

2018年11月,美国学者发表在《J Bone Miner Res》上的一项随机对照试验表明,老年黑人女性补充维生素D不会预防骨流失。

关注|老年急性髓系白血病治疗新拐点

近十年来,急性髓系白血病(AML)的治疗已取得较大进步。但与年轻AML取得的治疗进展相比,老年AML患者由于存在高龄、合并疾病多、不良染色体核型多、前驱血液系统疾病等不利预后因素,近年来疗效并未得到明显改善。近几年,美国血液病学会年会(ASH)、欧洲血液病学会年会(EHA)、美国临床肿瘤学会年会(ASCO)等国际会议报道的临床研究数据显示,一种口服B淋巴细胞瘤-2基因(BCL-2)抑制剂——Ven

Lancet Haematol:老年AML新的低强度方案:克拉屈滨+低剂量阿糖胞苷交替地西他宾

急性髓性白血病(AML)老年或不适患者因结局较差和过量的毒性仍对一线治疗不满意。研究人员研究了一种新的低强度方案,旨在改善该患者人群的结局,方案为克拉屈滨+低剂量阿糖胞苷交替地西他宾。2018年9月,发表在《Lancet Haematol》的一项单组、开放标签、单中心2期研究调查了这种新治疗方案的安全性和有效性。

Am J Kidney Dis:老年ESRD患者透析方式与房颤

由此可见,尽管使用腹膜透析开始透析治疗的患者在ESRD前90天内AF发生率较低,但此后AF发生率与血液透析之间没有显著差异。减少接受血液透析患者早期过度AF风险的干预措施的价值可能需要进一步研究。

Baidu
map
Baidu
map
Baidu
map