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Lancet:红外光谱血管内超声成像用于新发冠状动脉事件风险识别

2019-09-28 MedSci MedSci原创

对于PCI患者,非梗阻区域接受近红外光谱血管内超声成像是安全的,并有助于高危患者的识别

近红外光谱(NIRS)血管内超声成像可以检测富含脂质的斑块(LRPs)。LRPs与急性冠状动脉综合征或心肌梗死有关,可导致血管再通或心脏死亡。近日,研究人员考察在非支架部位进行NIRS-血管内超声LRPs检测与新发冠状动脉事件之间的关系。

研究在意大利、拉脱维亚、荷兰、斯洛伐克、英国和美国的44个医疗中心开展,疑似冠心病,符合PCI标准患者参与,患者在非支架部位进行NIRS超声显现。研究的主要终点为患检测最大4mm脂质核心负荷指数(Max-LCBI 4mm)与主要心血管事件(NC-MACE)之间的关系。

1563名患者参与研究,6名出现NIRS导致的不良事件(0.4%),患者平均年龄64岁,女性占31%。103人(9%)2年内发生NC-MACE事件。对于同一患者,Max-LCBI 4mm每增加100单位的NC-MACE风险为1.21,调整后为1.18。对于Max-LCBI 4mm超过400的患者,NC-MACE风险为2.18,调整后为1.89。在斑块的水平,Max-LCBI 4mm每增加100单位的NC-MACE风险为1.45,对于Max-LCBI 4mm超过400的患者,NC-MACE风险为4.22,调整后为3.39。

研究认为,对于PCI患者,非梗阻区域接受近红外光谱血管内超声成像是安全的,并有助于高危患者的识别。

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    2020-02-18 howi
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    2019-10-04 njwbhuang

    非常好的文章!

    0

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