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Liver Int:乙型肝炎病毒感染和非酒精性脂肪肝(NAFLD)风险:基于人群的队列研究

2018-07-27 MedSci MedSci原创

在中国CHB患者中,代谢因素对NAFLD的存在起着重要作用。然而,病毒复制因子与NAFLD没有关系,除了并发2型糖尿病患者。

研究背景:虽然非酒精性脂肪肝(NAFLD)已被广泛研究,但慢性乙型肝炎(CHB)患者发生NAFLD的潜在危险因素尚不清楚。

研究方法:从2012年10月至2015年1月,在中国江苏省招募了一群没有饮酒史或NAFLD的成人CHB患者。利用Cox比例危险回归模型,评估NAFLD的潜在危险因素。

研究结果:该队列共纳入2393例成人CHB患者(平均年龄50.7±13.2岁)。在4429人-年的随访期间,283例CHB患者发生NAFLD,发生率为63.89/1000人年。与正常体重携带者相比,超重和肥胖的CHB患者发生NAFLD的风险增加(超重调整危险率[HR]:3.10;95%置信区间,2.29-4.18; 肥胖患者的HR:8.52; 95%CI, 5.93-12.25)。NAFLD的发生率与并发2型糖尿病(DM)相关(HR, 1.88;95%可信区间,1.15-3.08)。然而,病毒因素与NAFLD发生率之间没有相关性。在一组并发2型糖尿病的参与者中,可检测的HBV DNA水平与NAFLD的发展呈负相关(HR, 0.37;95%可信区间,0.14-0.98)。BMI与性别对NAFLD发生率有交互的相乘作用,ROR为2.08 (95%CI, 1.02-4.23)。

研究结论:在中国CHB患者中,代谢因素对NAFLD的存在起着重要作用。然而,病毒复制因子与NAFLD没有关系,除了并发2型糖尿病患者。

原始出处:

Zhu L, Jiang J, Zhai X, et al. Hepatitis B virus infection and risk of non-alcoholic fatty liver disease (NAFLD): a population-based cohort study.

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    2019-02-16 lvygwyt2781
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  5. 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    2018-09-23 jyzxjiangqin

    乙型肝炎病毒感染的治疗。

    0

  6. 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    2018-09-12 jyzxjiangqin

    乙型肝炎病毒感染的治疗。

    0

  7. 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    2018-08-30 jyzxjiangqin

    乙型肝炎病毒感染的治疗。

    0

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    2018-08-19 jyzxjiangqin

    乙型肝炎病毒感染的治疗。

    0

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BMI增加与乳腺癌风险之间的关系很特殊,在绝经前风险下降而绝经后风险增加。在绝经前乳腺癌中这一负向关系尚未得到明确验证,但是其对理解乳腺癌发生的因果关系可能很重要。JAMA ONCOL近期发表了一篇文章,研究BMI与绝经前乳腺癌风险的关系。

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BMI与牙周炎之间的关系一直存在争议。有研究认为,不仅是过重/肥胖而且体重过低均与广泛型侵袭性牙周炎(GAgP)相关联。然而,BMI与GAgP之间确切的关系以及罹患GAgP最低风险的最佳BMI值还未可知。

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